Differential Mucosal Microbiome Profiles across Stages of Human Colorectal Cancer.
16S rRNA sequencing
colorectal cancer
gut microbiota
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
13 Aug 2021
13 Aug 2021
Historique:
received:
10
07
2021
revised:
12
08
2021
accepted:
12
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
28
8
2021
Statut:
epublish
Résumé
Emerging evidences link gut microbiota to colorectal cancer (CRC) initiation and development. However, the CRC stage- and spatial-specific bacterial taxa were less investigated, especially in a Chinese cohort, leading to our incomplete understanding of the functional roles of gut microbiota in promoting CRC progression and recurrence. Here, we report the composition and structure of gut microbiota across CRC stages I, II and III, by analyzing the gut mucosal microbiomes of 75 triplet-paired samples collected from on-tumor, adjacent-tumor and off-tumor sites and 26 healthy controls. We observed tumor-specific pattern of mucosal microbiome profiles as CRC progressed and identified ten bacterial taxa with high abundances (>1%) as potential biomarkers for tumor initiation and development.
Identifiants
pubmed: 34440574
pii: life11080831
doi: 10.3390/life11080831
pmc: PMC8401903
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : the Natural Science Foundation of China
ID : 81972826
Organisme : Tianjin 131 Innovative Talent Training Project
ID : 2018
Organisme : the Fundamental Research Funds for the Central Universities, Nankai University
ID : 63191440
Références
Front Cell Infect Microbiol. 2020 Aug 07;10:400
pubmed: 32850497
J Cancer. 2018 Apr 18;9(9):1652-1659
pubmed: 29760804
BMJ Open Gastroenterol. 2017 Jul 3;4(1):e000145
pubmed: 28944067
Infect Immun. 2009 Apr;77(4):1708-18
pubmed: 19188353
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
Sci Signal. 2020 Jul 21;13(641):
pubmed: 32694172
Cell Host Microbe. 2013 Aug 14;14(2):195-206
pubmed: 23954158
Gut Pathog. 2021 Jan 12;13(1):2
pubmed: 33436075
Gut. 2016 Dec;65(12):1973-1980
pubmed: 26311717
Int J Mol Sci. 2021 Feb 04;22(4):
pubmed: 33557173
J Diabetes Metab Disord. 2020 Aug 15;19(2):1061-1069
pubmed: 33520823
PLoS Pathog. 2021 Jan 6;17(1):e1009182
pubmed: 33406160
BMC Bioinformatics. 2014 Aug 29;15:293
pubmed: 25176396
Nat Commun. 2015 Oct 30;6:8727
pubmed: 26515465
JAMA Oncol. 2015 Aug;1(5):653-61
pubmed: 26181352
J Gastroenterol. 2015 Feb;50(2):167-79
pubmed: 24811328
J Infect Dis. 2011 Apr 15;203(8):1101-9
pubmed: 21451000
Sci Adv. 2020 May 15;6(20):eaba1590
pubmed: 32440552
Trends Microbiol. 2020 Jul;28(7):519-522
pubmed: 32544438
Front Med. 2019 Aug;13(4):461-470
pubmed: 31250341
CA Cancer J Clin. 2017 May 6;67(3):177-193
pubmed: 28248415
BMC Bioinformatics. 2012 Feb 14;13:31
pubmed: 22333067
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Nat Rev Microbiol. 2010 Jul;8(7):471-80
pubmed: 20514044
Sci Rep. 2016 May 19;6:26337
pubmed: 27194068
Mol Cell Proteomics. 2012 Oct;11(10):851-62
pubmed: 22713208
PLoS One. 2012;7(6):e39743
pubmed: 22761885
Brief Bioinform. 2018 Jul 20;19(4):679-692
pubmed: 28025179
Mol Cell Proteomics. 2021 Feb 10;:100057
pubmed: 33581319
mBio. 2018 Apr 24;9(2):
pubmed: 29691334
Front Microbiol. 2018 Apr 03;9:614
pubmed: 29666615
Nat Microbiol. 2019 Dec;4(12):2319-2330
pubmed: 31501538
World J Gastroenterol. 2016 Jan 14;22(2):501-18
pubmed: 26811603
J Oral Sci. 2019 Nov 27;61(4):526-528
pubmed: 31548454
Cell Host Microbe. 2013 Aug 14;14(2):207-15
pubmed: 23954159
Periodontol 2000. 1994 Jun;5:66-77
pubmed: 9673163
Nat Protoc. 2020 Mar;15(3):799-821
pubmed: 31942082
Nat Rev Cancer. 2013 Nov;13(11):800-12
pubmed: 24132111
J Appl Oral Sci. 2018 Jun 11;26:e20170516
pubmed: 29898181
Mol Cell. 2014 Apr 24;54(2):309-20
pubmed: 24766895
Anaerobe. 2020 Apr;62:102100
pubmed: 31521732
Gut Microbes. 2020 May 3;11(3):433-452
pubmed: 31411526
Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E283-E291
pubmed: 29279402
Nucleic Acids Res. 2017 Jul 3;45(W1):W180-W188
pubmed: 28449106