The Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and Protection.
COVID-19
basophil ETs
dendritic cell ETs
eosinophil ETs
extracellular traps (ETs)
lymphocyte ETs
macrophage ETs
mast cell ETs
neutrophils ETs
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
26 07 2021
26 07 2021
Historique:
received:
24
05
2021
revised:
12
07
2021
accepted:
14
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
22
9
2021
Statut:
epublish
Résumé
The first formal description of the microbicidal activity of extracellular traps (ETs) containing DNA occurred in neutrophils in 2004. Since then, ETs have been identified in different populations of cells involved in both innate and adaptive immune responses. Much of the knowledge has been obtained from in vitro or ex vivo studies; however, in vivo evaluations in experimental models and human biological materials have corroborated some of the results obtained. Two types of ETs have been described-suicidal and vital ETs, with or without the death of the producer cell. The studies showed that the same cell type may have more than one ETs formation mechanism and that different cells may have similar ETs formation mechanisms. ETs can act by controlling or promoting the mechanisms involved in the development and evolution of various infectious and non-infectious diseases, such as autoimmune, cardiovascular, thrombotic, and neoplastic diseases, among others. This review discusses the presence of ETs in neutrophils, macrophages, mast cells, eosinophils, basophils, plasmacytoid dendritic cells, and recent evidence of the presence of ETs in B lymphocytes, CD4+ T lymphocytes, and CD8+ T lymphocytes. Moreover, due to recently collected information, the effect of ETs on COVID-19 is also discussed.
Identifiants
pubmed: 34440659
pii: cells10081891
doi: 10.3390/cells10081891
pmc: PMC8391883
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : PAEF-IOC-Fiocruz
ID : IOC-023-FIO-18-2-47
Organisme : Programa Jovem Cientista do Nosso Estado
ID : Faperj -E-26/202.760/2019
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