Kinins and Their Receptors as Potential Therapeutic Targets in Retinal Pathologies.
age-related macular degeneration
diabetic retinopathy
kallikrein-kinin system
kinin receptors
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
28 07 2021
28 07 2021
Historique:
received:
14
06
2021
revised:
23
07
2021
accepted:
24
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
12
11
2021
Statut:
epublish
Résumé
The kallikrein-kinin system (KKS) contributes to retinal inflammation and neovascularization, notably in diabetic retinopathy (DR) and neovascular age-related macular degeneration (AMD). Bradykinin type 1 (B1R) and type 2 (B2R) receptors are G-protein-coupled receptors that sense and mediate the effects of kinins. While B2R is constitutively expressed and regulates a plethora of physiological processes, B1R is almost undetectable under physiological conditions and contributes to pathological inflammation. Several KKS components (kininogens, tissue and plasma kallikreins, and kinin receptors) are overexpressed in human and animal models of retinal diseases, and their inhibition, particularly B1R, reduces inflammation and pathological neovascularization. In this review, we provide an overview of the KKS with emphasis on kinin receptors in the healthy retina and their detrimental roles in DR and AMD. We highlight the crosstalk between the KKS and the renin-angiotensin system (RAS), which is known to be detrimental in ocular pathologies. Targeting the KKS, particularly the B1R, is a promising therapy in retinal diseases, and B1R may represent an effector of the detrimental effects of RAS (Ang II-AT1R).
Identifiants
pubmed: 34440682
pii: cells10081913
doi: 10.3390/cells10081913
pmc: PMC8391508
pii:
doi:
Substances chimiques
Kinins
0
Receptor, Bradykinin B1
0
Receptor, Bradykinin B2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : PJT-175061
Pays : Canada
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