Quantitative Proteomics Reveals Significant Differences between Mouse Brain Formations in Expression of Proteins Involved in Neuronal Plasticity during Aging.
Age Factors
Aging
/ metabolism
Animals
Cerebellum
/ metabolism
Cerebral Cortex
/ metabolism
Chromatography, Liquid
/ methods
Cognition
/ physiology
Female
Hippocampus
/ metabolism
Mice, Inbred C57BL
Neuronal Plasticity
/ physiology
Proteome
/ metabolism
Proteomics
/ methods
Signal Transduction
/ physiology
Synaptic Transmission
/ physiology
Tandem Mass Spectrometry
/ methods
Camk2
OXPHOS
cerebellum
cortex
extracellular matrix
glutamatergic and GABAergic transmission
hippocampus
total protein approach
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
07 08 2021
07 08 2021
Historique:
received:
30
06
2021
revised:
30
07
2021
accepted:
05
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Aging is associated with a general decline in cognitive functions, which appears to be due to alterations in the amounts of proteins involved in the regulation of synaptic plasticity. Here, we present a quantitative analysis of proteins involved in neurotransmission in three brain regions, namely, the hippocampus, the cerebral cortex and the cerebellum, in mice aged 1 and 22 months, using the total protein approach technique. We demonstrate that although the titer of some proteins involved in neurotransmission and synaptic plasticity is affected by aging in a similar manner in all the studied brain formations, in fact, each of the formations represents its own mode of aging. Generally, the hippocampal and cortical proteomes are much more unstable during the lifetime than the cerebellar proteome. The data presented here provide a general picture of the effect of physiological aging on synaptic plasticity and might suggest potential drug targets for anti-aging therapies.
Identifiants
pubmed: 34440790
pii: cells10082021
doi: 10.3390/cells10082021
pmc: PMC8393337
pii:
doi:
Substances chimiques
Proteome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Narodowe Centrum Nauki
ID : UMO-2020/37/B/NZ4/00808
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