Epigenetic Regulation in Melanoma: Facts and Hopes.
DNA methylation
chromatin remodeling
epigenetic drugs
epigenetics
melanoma
non-coding RNA
therapeutic resistance
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
11 08 2021
11 08 2021
Historique:
received:
26
06
2021
revised:
31
07
2021
accepted:
02
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Cutaneous melanoma is a lethal disease, even when diagnosed in advanced stages. Although recent progress in biology and treatment has dramatically improved survival rates, new therapeutic approaches are still needed. Deregulation of epigenetics, which mainly controls DNA methylation status and chromatin remodeling, is implied not only in cancer initiation and progression, but also in resistance to antitumor drugs. Epigenetics in melanoma has been studied recently in both melanoma preclinical models and patient samples, highlighting its potential role in different phases of melanomagenesis, as well as in resistance to approved drugs such as immune checkpoint inhibitors and MAPK inhibitors. This review summarizes what is currently known about epigenetics in melanoma and dwells on the recognized and potential new targets for testing epigenetic drugs, alone or together with other agents, in advanced melanoma patients.
Identifiants
pubmed: 34440824
pii: cells10082048
doi: 10.3390/cells10082048
pmc: PMC8392422
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
RNA, Untranslated
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Clin Cancer Res. 2009 Mar 1;15(5):1801-7
pubmed: 19223509
Cell. 2018 Jul 26;174(3):549-563.e19
pubmed: 29937226
Nat Commun. 2018 Nov 6;9(1):4627
pubmed: 30401823
Cell. 2007 Feb 23;128(4):693-705
pubmed: 17320507
Science. 2018 Feb 16;359(6377):770-775
pubmed: 29301958
J Invest Dermatol. 2014 Jun;134(6):1768-1772
pubmed: 24468746
Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):
pubmed: 33827917
Gene. 2007 Jan 15;386(1-2):1-10
pubmed: 17113247
Onco Targets Ther. 2017 Aug 08;10:3941-3947
pubmed: 28860801
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15840-5
pubmed: 21896753
Cancers (Basel). 2019 Mar 07;11(3):
pubmed: 30866509
Nat Rev Genet. 2016 May;17(5):284-99
pubmed: 26972587
Cell. 2018 Nov 15;175(5):1272-1288.e20
pubmed: 30343899
Trends Cell Biol. 2011 Jun;21(6):354-61
pubmed: 21550244
Oncotarget. 2017 Dec 24;9(9):8206-8222
pubmed: 29492189
Cancer Res. 2006 Dec 1;66(23):11187-93
pubmed: 17145863
Int J Mol Sci. 2013 Jul 18;14(7):15059-73
pubmed: 23873297
Ther Adv Med Oncol. 2020 Jun 19;12:1758835920925219
pubmed: 32612709
EMBO Mol Med. 2018 May;10(5):
pubmed: 29650805
Cancer Cell. 2013 Jun 10;23(6):811-25
pubmed: 23764003
Nat Med. 2018 Oct;24(10):1599-1610
pubmed: 30224758
Pigment Cell Melanoma Res. 2014 Nov;27(6):1126-37
pubmed: 24924589
Cancer Res. 2003 Jun 1;63(11):2881-90
pubmed: 12782594
Cancer. 1994 Aug 1;74(3):893-9
pubmed: 8039116
Cancer Chemother Pharmacol. 2014 Oct;74(4):691-7
pubmed: 25062770
Biomed Res Int. 2013;2013:251098
pubmed: 23862139
PLoS Genet. 2015 Oct 06;11(10):e1005555
pubmed: 26440048
Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8681-6
pubmed: 10411935
Curr Opin Chem Biol. 2020 Aug;57:41-49
pubmed: 32480315
Oncogene. 2012 Mar 22;31(12):1558-70
pubmed: 21860416
Cell Rep. 2017 Jul 25;20(4):854-867
pubmed: 28746871
Nat Commun. 2015 Jan 22;6:6051
pubmed: 25609585
Cancer Discov. 2020 Jul;10(7):980-997
pubmed: 32269030
Cell Mol Life Sci. 2014 Feb;71(3):379-404
pubmed: 23652611
Nat Rev Cancer. 2004 Feb;4(2):143-53
pubmed: 14732866
Virchows Arch. 2019 Apr;474(4):421-432
pubmed: 30747264
Genes Dev. 2011 May 15;25(10):1010-22
pubmed: 21576262
Yonsei Med J. 2020 Jul;61(7):562-571
pubmed: 32608199
Am J Pathol. 2012 Nov;181(5):1823-35
pubmed: 22982443
Expert Opin Drug Discov. 2017 Apr;12(4):345-362
pubmed: 28276705
Cancer Res. 2013 Oct 15;73(20):6264-76
pubmed: 23950209
JCI Insight. 2018 Jul 12;3(13):
pubmed: 29997292
Future Oncol. 2016 Nov;12(22):2531-2534
pubmed: 27715206
Pigment Cell Melanoma Res. 2019 May;32(3):435-440
pubmed: 30343532
Nature. 2010 Dec 23;468(7327):1105-9
pubmed: 21179167
J Invest Dermatol. 2014 Nov;134(11):2795-2805
pubmed: 24906137
Cancer Res. 2009 Nov 15;69(22):8693-9
pubmed: 19861533
Genes Cancer. 2011 Jun;2(6):607-17
pubmed: 21941617
J Natl Cancer Inst. 2008 Jun 4;100(11):784-95
pubmed: 18505964
Int J Oncol. 2020 Sep;57(3):609-618
pubmed: 32582963
Trends Immunol. 2019 Apr;40(4):328-344
pubmed: 30853334
Cancer Res. 2005 Oct 1;65(19):8635-9
pubmed: 16204030
Clin Cancer Res. 2018 Mar 15;24(6):1260-1270
pubmed: 29127120
Oncogene. 2015 Aug 20;34(34):4448-59
pubmed: 25417704
Am J Pathol. 2002 Jul;161(1):229-37
pubmed: 12107107
J Invest Dermatol. 2010 Feb;130(2):620-2
pubmed: 19798057
Cancer. 1999 Jan 1;85(1):112-8
pubmed: 9921982
Mol Cancer Ther. 2006 Aug;5(8):1967-74
pubmed: 16928817
Cancer Res. 2016 Sep 15;76(18):5277-87
pubmed: 27503933
Nature. 1983 Jan 6;301(5895):89-92
pubmed: 6185846
Cancer Res. 2004 Aug 15;64(16):5527-34
pubmed: 15313885
Cell. 2018 May 31;173(6):1413-1425.e14
pubmed: 29754815
J Immunother Cancer. 2020 Oct;8(2):
pubmed: 33037115
Cancer Res. 2003 Apr 1;63(7):1639-43
pubmed: 12670917
Melanoma Res. 2013 Oct;23(5):341-8
pubmed: 23963286
Clin Cancer Res. 2009 Apr 1;15(7):2479-87
pubmed: 19318485
Handb Exp Pharmacol. 2018;249:91-108
pubmed: 28275910
Clin Epigenetics. 2017 Apr 4;9:34
pubmed: 28396701
Epigenomics. 2009 Dec;1(2):239-59
pubmed: 20495664
Oncoimmunology. 2015 Apr 2;4(8):e1019978
pubmed: 26405573
Oncogene. 2019 May;38(22):4384-4396
pubmed: 30710146
Clin Cancer Res. 2005 Jul 1;11(13):4912-22
pubmed: 16000590
Cell. 2012 Sep 14;150(6):1135-46
pubmed: 22980977
Cancer Res. 2002 Nov 15;62(22):6456-61
pubmed: 12438235
Commun Biol. 2020 Jul 3;3(1):341
pubmed: 32620903
J Clin Oncol. 2006 Jan 10;24(2):268-73
pubmed: 16330673
Cell. 2010 May 14;141(4):583-94
pubmed: 20478252
Mol Cell. 2015 Jul 2;59(1):75-88
pubmed: 26051178
Mol Oncol. 2020 May;14(5):933-950
pubmed: 32147909
Pigment Cell Melanoma Res. 2011 Apr;24(2):352-60
pubmed: 21375697
Oncogene. 2015 Aug 13;34(33):4320-32
pubmed: 25381824
Genome Res. 2009 Aug;19(8):1462-70
pubmed: 19491193
Genes Dev. 2016 Apr 1;30(7):733-50
pubmed: 27036965
Cell. 2009 Jan 23;136(2):215-33
pubmed: 19167326
Pigment Cell Melanoma Res. 2013 Jul;26(4):542-54
pubmed: 23590314
Cell. 2015 Sep 10;162(6):1271-85
pubmed: 26359985
Nat Commun. 2018 Aug 24;9(1):3440
pubmed: 30143629
Cell. 2012 Jul 20;150(2):251-63
pubmed: 22817889
Nat Commun. 2021 Mar 19;12(1):1747
pubmed: 33741929
Cancer Biol Ther. 2007 Feb;6(2):185-91
pubmed: 17218782
Gut. 1996 Sep;39(3):434-8
pubmed: 8949650
Cancers (Basel). 2019 Oct 01;11(10):
pubmed: 31581557
Front Immunol. 2021 Apr 02;12:640369
pubmed: 33868269
Cell Death Differ. 2011 May;18(5):829-40
pubmed: 21127501
Cell. 2012 Nov 21;151(5):1068-82
pubmed: 23142051
Oncogene. 2001 Sep 13;20(41):5865-77
pubmed: 11593392
Ann Oncol. 2013 Apr;24(4):1112-9
pubmed: 23172636
Eur J Cancer. 2018 Mar;91:116-124
pubmed: 29360604
Cell Prolif. 2018 Aug;51(4):e12457
pubmed: 29582492
Blood. 1998 Dec 1;92(11):4296-307
pubmed: 9834236
Cancer Res. 2006 Jul 1;66(13):6546-52
pubmed: 16818626
Nature. 2011 Mar 24;471(7339):513-7
pubmed: 21430779
Int J Mol Sci. 2021 Mar 27;22(7):
pubmed: 33801689
Biochem Pharmacol. 2003 Oct 15;66(8):1537-45
pubmed: 14555232
Exp Dermatol. 2012 Jul;21(7):509-14
pubmed: 22716245
Neuro Oncol. 2014 Nov;16(11):1499-509
pubmed: 24968695
Cancer Discov. 2019 Apr;9(4):526-545
pubmed: 30709805
Clin Epigenetics. 2020 Jun 26;12(1):94
pubmed: 32586358
Signal Transduct Target Ther. 2019 Dec 17;4:62
pubmed: 31871779
Nature. 2001 Jan 11;409(6817):207-11
pubmed: 11196646
Melanoma Res. 2009 Jun;19(3):146-55
pubmed: 19441164
Nat Genet. 2017 Jan 31;49(2):178-179
pubmed: 28138149
Oncogene. 1999 Apr 15;18(15):2527-32
pubmed: 10229204
Cancer Discov. 2016 Jun;6(6):650-63
pubmed: 27179036
Theranostics. 2020 Jan 1;10(4):1777-1797
pubmed: 32042336
Cancers (Basel). 2021 Mar 24;13(7):
pubmed: 33804910
Clin Exp Metastasis. 1986 Oct-Dec;4(4):285-92
pubmed: 2431822
Nat Commun. 2013;4:1508
pubmed: 23443536
Nat Commun. 2021 Mar 9;12(1):1536
pubmed: 33750776
J Cutan Pathol. 2007 Aug;34(8):597-600
pubmed: 17640228
Cancer Res. 2013 Oct 1;73(19):5858-68
pubmed: 23801749
Cancer Cell. 2018 Feb 12;33(2):322-336.e8
pubmed: 29438700
Cancer Res. 1997 Dec 1;57(23):5336-47
pubmed: 9393758
Front Immunol. 2016 May 03;7:172
pubmed: 27199994
Oncotarget. 2017 Sep 26;8(51):89182-89193
pubmed: 29179510
Stem Cells. 2012 May;30(5):833-44
pubmed: 22489015
Nature. 2005 Jun 30;435(7046):1262-6
pubmed: 15988529
J Invest Dermatol. 2010 Dec;130(12):2809-17
pubmed: 20703244