Cell Therapy for Anal Sphincter Incontinence: Where Do We Stand?
anal incontinence
fecal incontinence
mesenchymal stem cell
mesenchymal stromal cell
mulitipotent cell
myoblast
progenitor cell
satellite cell
stem cell
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
13 08 2021
13 08 2021
Historique:
received:
30
06
2021
revised:
05
08
2021
accepted:
06
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
18
11
2021
Statut:
epublish
Résumé
Anal sphincter incontinence is a chronic disease, which dramatically impairs quality of life and induces high costs for the society. Surgery, considered as the best curative option, shows a disappointing success rate. Stem/progenitor cell therapy is pledging, for anal sphincter incontinence, a substitute to surgery with higher efficacy. However, the published literature is disparate. Our aim was to perform a review on the development of cell therapy for anal sphincter incontinence with critical analyses of its pitfalls. Animal models for anal sphincter incontinence were varied and tried to reproduce distinct clinical situations (acute injury or healed injury with or without surgical reconstruction) but were limited by anatomical considerations. Cell preparations used for treatment, originated, in order of frequency, from skeletal muscle, bone marrow or fat tissue. The characterization of these preparations was often incomplete and stemness not always addressed. Despite a lack of understanding of sphincter healing processes and the exact mechanism of action of cell preparations, this treatment was evaluated in 83 incontinent patients, reporting encouraging results. However, further development is necessary to establish the correct indications, to determine the most-suited cell type, to standardize the cell preparation method and to validate the route and number of cell delivery.
Identifiants
pubmed: 34440855
pii: cells10082086
doi: 10.3390/cells10082086
pmc: PMC8394955
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Hôpitaux Universitaires de Genève
ID : PRD 19-I-2020
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