The Chemically-Modified Tetracycline COL-3 and Its Parent Compound Doxycycline Prevent Microglial Inflammatory Responses by Reducing Glucose-Mediated Oxidative Stress.
COL-3
NADPH oxidase
glucose metabolism
microglia
neuroinflammation
oxidative stress
tetracyclines
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
22 08 2021
22 08 2021
Historique:
received:
29
06
2021
revised:
10
08
2021
accepted:
13
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
30
11
2021
Statut:
epublish
Résumé
We used mouse microglial cells in culture activated by lipopolysaccharide (LPS) or α-synuclein amyloid aggregates (αSa) to study the anti-inflammatory effects of COL-3, a tetracycline derivative without antimicrobial activity. Under LPS or αSa stimulation, COL-3 (10, 20 µM) efficiently repressed the induction of the microglial activation marker protein
Identifiants
pubmed: 34440932
pii: cells10082163
doi: 10.3390/cells10082163
pmc: PMC8392055
pii:
doi:
Substances chimiques
Tetracyclines
0
tetracycline CMT-3
0
Glucose
IY9XDZ35W2
Doxycycline
N12000U13O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : #Me928/19
Organisme : Investissements d'avenir
ID : ANR-10-IAIHU-06
Organisme : Translational Research Infrastructure for Biotherapies in Neurosciences
ID : ANR-11-INBS-0011-NeurATRIS
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2017/14207-7
Références
PLoS One. 2013;8(2):e57827
pubmed: 23469077
J Am Acad Dermatol. 2006 Feb;54(2):258-65
pubmed: 16443056
Glia. 2015 Mar;63(3):423-40
pubmed: 25331559
Glia. 2018 Jun;66(6):1200-1212
pubmed: 29219210
Glia. 2016 Nov;64(11):1912-24
pubmed: 27452488
Glia. 2020 Mar;68(3):561-573
pubmed: 31647138
EMBO J. 2001 Apr 17;20(8):1829-39
pubmed: 11296217
Arch Biochem Biophys. 2016 Aug 1;603:102-9
pubmed: 27246478
Neurotoxicology. 2021 Jul;85:254-264
pubmed: 34097939
Neurotox Res. 2009 Nov;16(4):361-71
pubmed: 19582534
Br J Pharmacol. 2021 Jul;178(13):2595-2616
pubmed: 33751546
Cell Chem Biol. 2018 Dec 20;25(12):1506-1518.e13
pubmed: 30318461
FASEB J. 2005 Apr;19(6):533-42
pubmed: 15791003
Front Pharmacol. 2021 Jan 11;11:617085
pubmed: 33510643
Sci Rep. 2020 Nov 20;10(1):20258
pubmed: 33219264
Glia. 2013 Jul;61(7):1084-100
pubmed: 23595698
Sci Rep. 2017 Feb 03;7:41755
pubmed: 28155912
Gene. 2018 Mar 1;645:85-94
pubmed: 29248584
Invest New Drugs. 2007 Aug;25(4):359-67
pubmed: 17237909
Neurotherapeutics. 2011 Apr;8(2):206-20
pubmed: 21455784
Adv Dent Res. 1998 Nov;12(2):12-26
pubmed: 9972117
Glia. 2017 Jul;65(7):1176-1185
pubmed: 28471051
J Neural Transm (Vienna). 2018 Oct;125(10):1403-1415
pubmed: 30109452
Nat Commun. 2019 Oct 11;10(1):4623
pubmed: 31604916
J Clin Oncol. 2001 Jan 15;19(2):584-92
pubmed: 11208854
Clin Cosmet Investig Dermatol. 2009 Aug 12;2:129-40
pubmed: 21436975
Physiol Rev. 2007 Jan;87(1):245-313
pubmed: 17237347
Science. 2009 May 22;324(5930):1029-33
pubmed: 19460998
Exp Cell Res. 2019 Apr 15;377(1-2):10-16
pubmed: 30817930
Front Aging Neurosci. 2021 Mar 22;13:635760
pubmed: 33828477
Cells. 2019 Jul 25;8(8):
pubmed: 31349736
Med Princ Pract. 2013;22(1):35-41
pubmed: 22907189
Clin Cancer Res. 2004 Oct 1;10(19):6512-21
pubmed: 15475438
J Mol Biol. 2002 Sep 13;322(2):383-93
pubmed: 12217698
CNS Neurol Disord Drug Targets. 2009 Jun;8(3):222-31
pubmed: 19601819
Luminescence. 2012 Jul-Aug;27(4):249-55
pubmed: 22887986
Oncotarget. 2017 Mar 7;8(10):16829-16842
pubmed: 28187433
Mol Pharmacol. 2013 Dec;84(6):888-98
pubmed: 24077968
J Clin Oncol. 2006 Mar 20;24(9):1389-94
pubmed: 16549833
J Neuroinflammation. 2020 Oct 23;17(1):316
pubmed: 33097087
Ann N Y Acad Sci. 1999 Jun 30;878:290-310
pubmed: 10415737
Neurotox Res. 2016 May;29(4):447-59
pubmed: 26745968
Mol Cancer. 2017 Feb 8;16(1):36
pubmed: 28178994
Sci Rep. 2019 Jan 29;9(1):840
pubmed: 30696869
Glia. 2005 Oct;52(1):78-84
pubmed: 15920727
Int J Mol Sci. 2018 Dec 17;19(12):
pubmed: 30562944
Glia. 2018 Nov;66(11):2353-2365
pubmed: 30394585
Inflammation. 2009 Apr;32(2):130-7
pubmed: 19238528