Of Screening, Stratification, and Scores.
bioethics
cancer screening
law
personalized medicine
polygenic risk scores
stratification
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
28 Jul 2021
28 Jul 2021
Historique:
received:
06
07
2021
accepted:
24
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
28
8
2021
Statut:
epublish
Résumé
Technological innovations including risk-stratification algorithms and large databases of longitudinal population health data and genetic data are allowing us to develop a deeper understanding how individual behaviors, characteristics, and genetics are related to health risk. The clinical implementation of risk-stratified screening programmes that utilise risk scores to allocate patients into tiers of health risk is foreseeable in the future. Legal and ethical challenges associated with risk-stratified cancer care must, however, be addressed. Obtaining access to the rich health data that are required to perform risk-stratification, ensuring equitable access to risk-stratified care, ensuring that algorithms that perform risk-scoring are representative of human genetic diversity, and determining the appropriate follow-up to be provided to stratification participants to alert them to changes in their risk score are among the principal ethical and legal challenges. Accounting for the great burden that regulatory requirements could impose on access to risk-scoring technologies is another critical consideration.
Identifiants
pubmed: 34442379
pii: jpm11080736
doi: 10.3390/jpm11080736
pmc: PMC8398020
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Genome Canada
ID : Personalized risk assessment for prevention and early detection of breast cancer: Integration and Implementation. 2018/04-2022/03.
Organisme : Genome Quebec
ID : Personalized risk assessment for prevention and early detection of breast cancer: Integration and Implementation. 2018/04-2022/03.
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