Identification of

childhood asthma exacerbations forced expiratory volume in one second genome-wide association study inhaled corticosteroids single nucleotide polymorphism

Journal

Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269

Informations de publication

Date de publication:
28 Jul 2021
Historique:
received: 18 07 2021
accepted: 26 07 2021
entrez: 27 8 2021
pubmed: 28 8 2021
medline: 28 8 2021
Statut: epublish

Résumé

Inhaled corticosteroids (ICS) are the most common asthma controller medication. An important contribution of genetic factors in ICS response has been evidenced. Here, we aimed to identify novel genetic markers involved in ICS response in asthma. A genome-wide association study (GWAS) of the change in lung function after 6 weeks of ICS treatment was performed in 166 asthma patients from the SLOVENIA study. Patients with an improvement in lung function ≥8% were considered as ICS responders. Suggestively associated variants (

Identifiants

DOI: 10.3390/jpm11080733 PMID: 34442380 PMC: PMC8399629
pubmed: 34442380
pii: jpm11080733
doi: 10.3390/jpm11080733
pmc: PMC8399629
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Instituto de Salud Carlos III (ISCIII) through Strategic Action for Health Research (AES) and European Community (EC) within the Active and Assisted Living (AAL) Programme framework
ID : AC15/00015
Organisme : ERACoSysMed 1st Joint Transnational Call from the European Union under the Horizon 2020
ID : SysPharmPedia
Organisme : Spanish Ministry of Science, Innovation, and Universities, the State Research Agency, and the European Regional Development Fund from the European Union
ID : SAF2017-83417R
Organisme : ISCIII, European Regional Development Fund
ID : FI16/00136
Organisme : Spanish Ministry of Economy, Industry and Competitiveness
ID : RYC-2015-17205
Organisme : GlaxoSmithKline
ID : NA
Organisme : Utrecht Institute for Pharmaceutical Sciences
ID : NA
Organisme : Slovenian Research Agency
ID : P3-0067
Organisme : Ministry of Education, Science and Sport Slovenia
ID : C3330-16-500106
Organisme : National Heart, Lung, and Blood Institute of the National Institute of Health
ID : R01HL117004
Organisme : National Heart, Lung, and Blood Institute of the National Institute of Health
ID : X01HL134589
Organisme : Sandler Family Foundation, the American Asthma Foundation, the RWJF Amos Medical Faculty Development Program, Harry Wm. and Diana V. Hind Distinguished Professor in Pharmaceutical Sciences II
ID : NA
Organisme : NIEHS NIH HHS
ID : R01ES015794
Pays : United States
Organisme : National Heart, Lung, and Blood Institute of the National Institute of Health
ID : R01HL117004
Organisme : National Heart, Lung, and Blood Institute of the National Institute of Health
ID : X01HL134589
Organisme : Sandler Family Foundation, the American Asthma Foundation, the RWJF Amos Medical Faculty Development Program, Harry Wm. and Diana V. Hind Distinguished Professor in Pharmaceutical Sciences II
ID : NA
Organisme : NHS Research Scotland and The Wellcome Trust Biomedical Resource
ID : 099177/Z/12/Z
Organisme : ISCIII and European Regional Development Fund
ID : PT17/0019
Organisme : ZonMw
ID : 113201006
Pays : Netherlands
Organisme : NHS Chair of Pharmacogenetics via the UK Department of Health
ID : NA
Organisme : National Institute of General Medical Sciences of the National Institutes of Health
ID : 5T32GM007546-42

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Auteurs

Natalia Hernandez-Pacheco (N)

Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Carretera General del Rosario 145, 38010 Santa Cruz de Tenerife, Spain.
Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez s/n, Faculty of Science, Apartado 456, 38200 San Cristóbal de La Laguna, Spain.
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Avenida de Monforte de Lemos, 5, 28029 Madrid, Spain.

Mario Gorenjak (M)

Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Taborska Ulica 8, 2000 Maribor, Slovenia.
ORCID: 0000-0003-4208-9683

Jiang Li (J)

The Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.
ORCID: 0000-0002-9791-2553

Katja Repnik (K)

Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Taborska Ulica 8, 2000 Maribor, Slovenia.
Laboratory for Biochemistry, Molecular Biology, and Genomics, Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, 2000 Maribor, Slovenia.

Susanne J Vijverberg (SJ)

Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Princetonplein 5, 3584 CC Utrecht, The Netherlands.
Department of Pediatric Respiratory Medicine and Allergy, Emma's Children Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

Vojko Berce (V)

Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Taborska Ulica 8, 2000 Maribor, Slovenia.
Department of Pediatrics, University Medical Centre Maribor, Ljubljanska Ulica 5, 2000 Maribor, Slovenia.
ORCID: 0000-0002-0577-8925

Andrea Jorgensen (A)

Department of Biostatistics, University of Liverpool, Crown Street, Liverpool L69 3BX, UK.

Leila Karimi (L)

Department of Medical Informatics, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
ORCID: 0000-0002-1746-3314

Maximilian Schieck (M)

Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

Lesly-Anne Samedy-Bates (LA)

Department of Medicine, University of California, San Francisco, CA 94143, USA.
Department of Bioengineering and Therapeutic Sciences, University of California, 533 Parnassus Ave, San Francisco, CA 94143, USA.

Roger Tavendale (R)

Population Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital, and Medical School, University of Dundee, Dundee DD1 9SY, UK.

Jesús Villar (J)

CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Avenida de Monforte de Lemos, 5, 28029 Madrid, Spain.
Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrín, Calle Barranco de la Ballena s/n, 35019 Las Palmas de Gran Canaria, Spain.
Keenan Research Center for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, 30 Bond St, Toronto, ON M5B 1W8, Canada.
ORCID: 0000-0001-5687-3562

Somnath Mukhopadhyay (S)

Population Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital, and Medical School, University of Dundee, Dundee DD1 9SY, UK.
Academic Department of Paediatrics, Brighton and Sussex Medical School, Royal Alexandra Children's Hospital, 94 N-S Rd, Falmer, Brighton BN2 5BE, UK.

Munir Pirmohamed (M)

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, 200 London Rd, Liverpool L3 9TA, UK.
ORCID: 0000-0002-7534-7266

Katia M C Verhamme (KMC)

Department of Medical Informatics, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

Michael Kabesch (M)

Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.

Daniel B Hawcutt (DB)

Department of Women's and Children's Health, University of Liverpool, Liverpool L69 3BX, UK.
Alder Hey Children's Hospital, E Prescot Rd, Liverpool L14 5AB, UK.

Steve Turner (S)

Child Health, University of Aberdeen, King's College, Aberdeen AB24 3FX, UK.
ORCID: 0000-0001-8393-5060

Colin N Palmer (CN)

Population Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital, and Medical School, University of Dundee, Dundee DD1 9SY, UK.

Kelan G Tantisira (KG)

The Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.

Esteban G Burchard (EG)

Department of Medicine, University of California, San Francisco, CA 94143, USA.
Department of Bioengineering and Therapeutic Sciences, University of California, 533 Parnassus Ave, San Francisco, CA 94143, USA.

Anke H Maitland-van der Zee (AH)

Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Princetonplein 5, 3584 CC Utrecht, The Netherlands.
Department of Pediatric Respiratory Medicine and Allergy, Emma's Children Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
ORCID: 0000-0002-0414-3442

Carlos Flores (C)

Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Carretera General del Rosario 145, 38010 Santa Cruz de Tenerife, Spain.
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Avenida de Monforte de Lemos, 5, 28029 Madrid, Spain.
Genomics Division, Instituto Tecnológico y de Energías Renovables (ITER), Polígono Industrial de Granadilla, 38600 Granadilla, Spain.
Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna, Faculty of Health Sciences, Apartado 456, 38200 San Cristóbal de La Laguna, Spain.
ORCID: 0000-0001-5352-069X

Uroš Potočnik (U)

Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Taborska Ulica 8, 2000 Maribor, Slovenia.
Laboratory for Biochemistry, Molecular Biology, and Genomics, Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, 2000 Maribor, Slovenia.
ORCID: 0000-0003-1624-9428

Maria Pino-Yanes (M)

Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez s/n, Faculty of Science, Apartado 456, 38200 San Cristóbal de La Laguna, Spain.
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Avenida de Monforte de Lemos, 5, 28029 Madrid, Spain.
Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna, Faculty of Health Sciences, Apartado 456, 38200 San Cristóbal de La Laguna, Spain.
ORCID: 0000-0003-0332-437X

Classifications MeSH