Repurposing of the Fasciolicide Triclabendazole to Treat Infections Caused by

bacterial pathogens bioluminescence multidrug resistance polymyxin B sepsis triclabendazole

Journal

Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893

Informations de publication

Date de publication:
10 Aug 2021
Historique:
received: 30 06 2021
revised: 02 08 2021
accepted: 03 08 2021
entrez: 27 8 2021
pubmed: 28 8 2021
medline: 28 8 2021
Statut: epublish

Résumé

One approach to combat the increasing incidence of multidrug-resistant (MDR) bacterial pathogens involves repurposing existing compounds with known safety and development pathways as new antibacterial classes with potentially novel mechanisms of action. Here, triclabendazole (TCBZ), a drug originally developed to treat

Identifiants

pubmed: 34442776
pii: microorganisms9081697
doi: 10.3390/microorganisms9081697
pmc: PMC8398527
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Australian Research Council
ID : LP130100736

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Auteurs

Hongfei Pi (H)

Australian Centre for Antimicrobial Resistance Ecology, Roseworthy Campus, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5371, Australia.

Abiodun D Ogunniyi (AD)

Australian Centre for Antimicrobial Resistance Ecology, Roseworthy Campus, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5371, Australia.

Bhumi Savaliya (B)

Australian Centre for Antimicrobial Resistance Ecology, Roseworthy Campus, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5371, Australia.

Hang Thi Nguyen (HT)

Australian Centre for Antimicrobial Resistance Ecology, Roseworthy Campus, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5371, Australia.
Department of Pharmacology, Toxicology, Internal Medicine and Diagnostics, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi 100000, Vietnam.

Stephen W Page (SW)

Luoda Pharma Pty Ltd., Caringbah, NSW 2229, Australia.

Ernest Lacey (E)

Microbial Screening Technologies Pty Ltd., Smithfield, NSW 2164, Australia.

Henrietta Venter (H)

Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.

Darren J Trott (DJ)

Australian Centre for Antimicrobial Resistance Ecology, Roseworthy Campus, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5371, Australia.

Classifications MeSH