The New Generation
SARS-CoV-2
antiviral activity
broad-spectrum antiviral
combination treatment
coronavirus
hDHODH inhibitor
organoids
pyrimidine biosynthesis
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
14 Aug 2021
14 Aug 2021
Historique:
received:
26
07
2021
revised:
03
08
2021
accepted:
13
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
28
8
2021
Statut:
epublish
Résumé
Although coronaviruses (CoVs) have long been predicted to cause zoonotic diseases and pandemics with high probability, the lack of effective anti-pan-CoVs drugs rapidly usable against the emerging SARS-CoV-2 actually prevented a promptly therapeutic intervention for COVID-19. Development of host-targeting antivirals could be an alternative strategy for the control of emerging CoVs infections, as they could be quickly repositioned from one pandemic event to another. To contribute to these pandemic preparedness efforts, here we report on the broad-spectrum CoVs antiviral activity of MEDS433, a new inhibitor of the human dihydroorotate dehydrogenase (
Identifiants
pubmed: 34442810
pii: microorganisms9081731
doi: 10.3390/microorganisms9081731
pmc: PMC8398173
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : FISR2020IP_01252
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : 2017HWPZZZ_002
Organisme : Associazione Angela Serra per la Ricerca sul Cancro
ID : AIRC IG 2019 DIORAMA 23344
Organisme : Ministero degli Affari Esteri e della Cooperazione Internazionale
ID : PGR01071 Italia/Svezia
Organisme : Regione Piemonte
ID : PAR FSC INFRA-P2 B
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