Phenolics-Rich Extracts of Dietary Plants as Regulators of Fructose Uptake in Caco-2 Cells via GLUT5 Involvement.
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
/ genetics
Biological Transport
/ drug effects
Caco-2 Cells
Carrier Proteins
/ genetics
Diet
Fructose
/ metabolism
Gene Expression Regulation
/ drug effects
Glucose Transporter Type 5
/ metabolism
Humans
Phenols
/ analysis
Plant Extracts
/ pharmacology
RNA, Messenger
/ genetics
Caco-2
GLUT5
fructose
phenolic compounds
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
05 Aug 2021
05 Aug 2021
Historique:
received:
14
07
2021
revised:
01
08
2021
accepted:
03
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
7
9
2021
Statut:
epublish
Résumé
The latest data link the chronic consumption of large amounts of fructose present in food with the generation of hypertension and disturbances in carbohydrate and lipid metabolism, which promote the development of obesity, non-alcoholic fatty liver disease, insulin resistance, and type 2 diabetes. This effect is possible after fructose is absorbed by the small intestine cells and, to a lesser extent, by hepatocytes. Fructose transport is dependent on proteins from the family of glucose transporters (GLUTs), among which GLUT5 selectively absorbs fructose from the intestine. In this study, we examined the effect of four phenolic-rich extracts obtained from
Identifiants
pubmed: 34443333
pii: molecules26164745
doi: 10.3390/molecules26164745
pmc: PMC8401051
pii:
doi:
Substances chimiques
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
0
Carrier Proteins
0
Glucose Transporter Type 5
0
MLXIPL protein, human
0
Phenols
0
Plant Extracts
0
RNA, Messenger
0
TXNIP protein, human
0
Fructose
30237-26-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The National Science Centre, Poland
ID : 2019/03/X/NZ9/01254
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