Synthesis and In Vitro Characterization of Glycopeptide Drug Candidates Related to PACAP
Brain
/ drug effects
Glycopeptides
/ chemical synthesis
Humans
Inflammation
/ drug therapy
Neurodegenerative Diseases
/ drug therapy
Neuroprotective Agents
/ chemical synthesis
Peptide Fragments
/ chemical synthesis
Peptide Hormones
/ chemical synthesis
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
/ drug effects
Receptors, Vasoactive Intestinal Peptide, Type II
/ antagonists & inhibitors
Receptors, Vasoactive Intestinal Polypeptide, Type I
/ drug effects
Alzheimer’s
Parkinson’s
glycopeptide
glycosylation
stroke
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
14 Aug 2021
14 Aug 2021
Historique:
received:
22
07
2021
revised:
10
08
2021
accepted:
11
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
25
9
2021
Statut:
epublish
Résumé
The search for efficacious treatment of neurodegenerative and progressive neuroinflammatory diseases continues, as current therapies are unable to halt or reverse disease progression. PACAP represents one potential therapeutic that provides neuroprotection effects on neurons, and also modulates inflammatory responses and circulation within the brain. However, PACAP is a relatively long peptide hormone that is not trivial to synthesize. Based on previous observations that the shortened isoform PACAP
Identifiants
pubmed: 34443519
pii: molecules26164932
doi: 10.3390/molecules26164932
pmc: PMC8401035
pii:
doi:
Substances chimiques
Glycopeptides
0
Neuroprotective Agents
0
Peptide Fragments
0
Peptide Hormones
0
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
0
Receptors, Vasoactive Intestinal Peptide, Type II
0
Receptors, Vasoactive Intestinal Polypeptide, Type I
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R01NS091238
Pays : United States
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