TRPM2 Oxidation Activates Two Distinct Potassium Channels in Melanoma Cells through Intracellular Calcium Increase.

Calcium / metabolism Cell Line, Tumor Humans Intermediate-Conductance Calcium-Activated Potassium Channels / metabolism Large-Conductance Calcium-Activated Potassium Channel alpha Subunits / metabolism Melanoma / metabolism Oxidation-Reduction TRPM Cation Channels / metabolism
TRP channels intracellular calcium melanoma oxidative stress potassium channels

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
04 Aug 2021
Historique:
received: 28 06 2021
revised: 29 07 2021
accepted: 02 08 2021
entrez: 27 8 2021
pubmed: 28 8 2021
medline: 21 9 2021
Statut: epublish

Résumé

Tumor microenvironments are often characterized by an increase in oxidative stress levels. We studied the response to oxidative stimulation in human primary (IGR39) or metastatic (IGR37) cell lines obtained from the same patient, performing patch-clamp recordings, intracellular calcium ([Ca

Identifiants

DOI: 10.3390/ijms22168359 PMID: 34445066 PMC: PMC8393965
pubmed: 34445066
pii: ijms22168359
doi: 10.3390/ijms22168359
pmc: PMC8393965
pii:
doi:

Substances chimiques

Intermediate-Conductance Calcium-Activated Potassium Channels 0
KCNMA1 protein, human 0
KCNN4 protein, human 0
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits 0
TRPM Cation Channels 0
TRPM2 protein, human 0
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG 21558
Organisme : Italian Ministry of Research
ID : PRIN 20174TB8KW

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Auteurs

Loretta Ferrera (L)

Biophysics Institute, National Research Council, 16149 Genova, Italy.
U.O.C. Genetica Medica, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, 16147 Genoa, Italy.
ORCID: 0000-0003-0528-1158

Raffaella Barbieri (R)

Biophysics Institute, National Research Council, 16149 Genova, Italy.
ORCID: 0000-0001-8254-9758

Cristiana Picco (C)

Biophysics Institute, National Research Council, 16149 Genova, Italy.
ORCID: 0000-0002-6512-1802

Paolo Zuccolini (P)

Biophysics Institute, National Research Council, 16149 Genova, Italy.

Alessia Remigante (A)

Biophysics Institute, National Research Council, 16149 Genova, Italy.
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.
ORCID: 0000-0001-9934-293X

Sara Bertelli (S)

Biophysics Institute, National Research Council, 16149 Genova, Italy.

Maria Rita Fumagalli (MR)

Biophysics Institute, National Research Council, 16149 Genova, Italy.
Center for Complexity and Biosystems, Department of Environmental Science and Policy, University of Milan, 20133 Milano, Italy.

Giovanni Zifarelli (G)

Biophysics Institute, National Research Council, 16149 Genova, Italy.

Caterina A M La Porta (CAM)

Biophysics Institute, National Research Council, 16149 Genova, Italy.
Center for Complexity and Biosystems, Department of Environmental Science and Policy, University of Milan, 20133 Milano, Italy.
ORCID: 0000-0002-3010-8966

Paola Gavazzo (P)

Biophysics Institute, National Research Council, 16149 Genova, Italy.

Michael Pusch (M)

Biophysics Institute, National Research Council, 16149 Genova, Italy.
ORCID: 0000-0002-8644-8847

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › TRPM2 Oxidation Activates Two Distinct...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › TRPM2 Oxidation Activates Two Distinct...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › TRPM2 Oxidation Activates Two Distinct...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques calcium-dépendants › Canaux potassiques calcium-dépendants de conductance intermédiaire › TRPM2 Oxidation Activates Two Distinct...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques calcium-dépendants › Canaux potassiques calcium-dépendants de grande conductance › Sous-unités alpha des canaux potassiques calcium-dépendants de grande conductance › TRPM2 Oxidation Activates Two Distinct...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › TRPM2 Oxidation Activates Two Distinct...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › TRPM2 Oxidation Activates Two Distinct...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux cationiques TRP › Canaux cationiques TRPM › TRPM2 Oxidation Activates Two Distinct...