Melatonin as a Potential Adjuvant Treatment for COVID-19 beyond Sleep Disorders.
COVID-19
disease progression
melatonin
physiological effects
treatment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Aug 2021
11 Aug 2021
Historique:
received:
29
06
2021
revised:
05
08
2021
accepted:
06
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
1
9
2021
Statut:
epublish
Résumé
Melatonin is registered to treat circadian rhythm sleep-wake disorders and insomnia in patients aged 55 years and over. The essential role of the circadian sleep rhythm in the deterioration of sleep quality during COVID-19 confinement and the lack of an adverse effect of melatonin on respiratory drive indicate that melatonin has the potential to be a recommended treatment for sleep disturbances related to COVID-19. This review article describes the effects of melatonin additional to its sleep-related effects, which make this drug an attractive therapeutic option for treating patients with COVID-19. The preclinical data suggest that melatonin may inhibit COVID-19 progression. It may lower the risk of the entrance of the SARS-CoV-2 virus into cells, reduce uncontrolled hyper-inflammation and the activation of immune cells, limit the damage of tissues and multiorgan failure due to the action of free radicals, and reduce ventilator-induced lung injury and the risk of disability resulting from fibrotic changes within the lungs. Melatonin may also increase the efficacy of COVID-19 vaccination. The high safety profile of melatonin and its potential anti-SARS-CoV-2 effects make this molecule a preferable drug for treating sleep disturbances in COVID-19 patients. However, randomized clinical trials are needed to verify the clinical usefulness of melatonin in the treatment of COVID-19.
Identifiants
pubmed: 34445329
pii: ijms22168623
doi: 10.3390/ijms22168623
pmc: PMC8395320
pii:
doi:
Substances chimiques
COVID-19 Vaccines
0
Cytokines
0
Free Radical Scavengers
0
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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