Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin.
asebia
cutaneous phenotype
peroxisome proliferator-activated receptor gamma
transcriptomic changes
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Aug 2021
11 Aug 2021
Historique:
received:
16
12
2020
revised:
29
07
2021
accepted:
02
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
16
9
2021
Statut:
epublish
Résumé
Both agonist studies and loss-of-function models indicate that PPARγ plays an important role in cutaneous biology. Since PPARγ has a high level of basal activity, we hypothesized that epidermal PPARγ would regulate normal homeostatic processes within the epidermis. In this current study, we performed mRNA sequencing and differential expression analysis of epidermal scrapings from knockout mice and wildtype littermates.
Identifiants
pubmed: 34445339
pii: ijms22168634
doi: 10.3390/ijms22168634
pmc: PMC8395473
pii:
doi:
Substances chimiques
PPAR gamma
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : U.S. Department of Veterans Affairs
ID : IK2CX001019
Organisme : CSRD VA
ID : I01 CX002046
Pays : United States
Organisme : U.S. Department of Veterans Affairs
ID : I01-BX003762
Organisme : Lilly Endowment
ID : Indiana Genomic Initiative at Indiana University
Organisme : BLRD VA
ID : I01 BX003762
Pays : United States
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