The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review.
brain-derived neurotrophic factor
exercise
neurotrophin-4
neurotrophins
peripheral circulation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Aug 2021
16 Aug 2021
Historique:
received:
21
06
2021
revised:
26
07
2021
accepted:
06
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
14
9
2021
Statut:
epublish
Résumé
(1) Background: One mechanism through which physical activity (PA) provides benefits is by triggering activity at a molecular level, where neurotrophins (NTs) are known to play an important role. However, the expression of the circulating levels of neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4/5), in response to exercise, is not fully understood. Therefore, the aim was to provide an updated overview on the neurotrophin (NT) variation levels of BDNF and NT-4/5 as a consequence of a long-term aerobic exercise intervention, and to understand and describe whether the upregulation of circulating NT levels is a result of neurotrophic factors produced and released from the brain, and/or from neurotrophic secreting peripheral organs. (2) Methods: The articles were collected from PubMed, SPORTDiscus, Web of Science, MEDLINE, and Embase. Data were analyzed through a narrative synthesis. (3) Results: 30 articles studied humans who performed training protocols that ranged from 4 to 48 weeks; 22 articles studied rodents with an intervention period that ranged from 4 to 64 weeks. (4) Conclusions: There is no unanimity between the upregulation of BDNF in humans; conversely, concerning both BDNF and NT-4/5 in animal models, the results are heterogeneous. Whilst BDNF upregulation appears to be in relative agreement, NT-4/5 seems to display contradictory and inconsistent conclusions.
Identifiants
pubmed: 34445512
pii: ijms22168814
doi: 10.3390/ijms22168814
pmc: PMC8396229
pii:
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Nerve Growth Factors
0
BDNF protein, human
7171WSG8A2
neurotrophin 4
P658DCA9XD
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Speed, crash and run: exersomes boost neuroenergetics and mood in mice on speed project
ID : POCI-01-0145-FEDER-030786; PTDC/SAU-DES/30786/2017
Organisme : Strategic Projects
ID : UID/NEU/04539/2013 and UID/NEU/ 04539/2019
Organisme : COMPETE-FEDER
ID : POCI-01-0145-FEDER-007440
Organisme : Centro 2020 Regional Operational Programmes
ID : CENTRO-01-0145-FEDER-000012: HealthyAging2020 and CENTRO-01-0145-FEDER- 000008: BrainHealth 2020
Organisme : Strategic Project
ID : UIDB/04539/2020 and UIDP/04539/2020
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