Role of Neuroinflammation and Blood-Brain Barrier Permutability on Migraine.
IL-1β
anakinra
blood-brain barrier
chemokine
migraine
neuroinflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Aug 2021
19 Aug 2021
Historique:
received:
22
07
2021
revised:
14
08
2021
accepted:
16
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
15
9
2021
Statut:
epublish
Résumé
Currently, migraine is treated mainly by targeting calcitonin gene-related peptides, although the efficacy of this method is limited and new treatment strategies are desired. Neuroinflammation has been implicated in the pathogenesis of migraine. In patients with migraine, peripheral levels of pro-inflammatory cytokines, such as interleukin-1β (IL-1β) and tumor necrosis factor-α, are known to be increased. Additionally, animal models of headache have demonstrated that immunological responses associated with cytokines are involved in the pathogenesis of migraine. Furthermore, these inflammatory mediators might alter the function of tight junctions in brain vascular endothelial cells in animal models, but not in human patients. Based on clinical findings showing elevated IL-1β, and experimental findings involving IL-1β and both the peripheral trigeminal ganglion and central trigeminal vascular pathways, regulation of the Il-1β/IL-1 receptor type 1 axis might lead to new treatments for migraine. However, the integrity of the blood-brain barrier is not expected to be affected during attacks in patients with migraine.
Identifiants
pubmed: 34445635
pii: ijms22168929
doi: 10.3390/ijms22168929
pmc: PMC8396312
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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