Furnishing Wound Repair by the Subcutaneous Fascia.
fascia
fibrosis
scar
skin
subcutaneous fascia
superficial fascia
wound healing
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Aug 2021
20 Aug 2021
Historique:
received:
02
07
2021
revised:
10
08
2021
accepted:
17
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Mammals rapidly heal wounds through fibrous connective tissue build up and tissue contraction. Recent findings from mouse attribute wound healing to physical mobilization of a fibroelastic connective tissue layer that resides beneath the skin, termed subcutaneous fascia or superficial fascia, into sites of injury. Fascial mobilization assembles diverse cell types and matrix components needed for rapid wound repair. These observations suggest that the factors directly affecting fascial mobility are responsible for chronic skin wounds and excessive skin scarring. In this review, we discuss the link between the fascia's unique tissue anatomy, composition, biomechanical, and rheologic properties to its ability to mobilize its tissue assemblage. Fascia is thus at the forefront of tissue pathology and a better understanding of how it is mobilized may crystallize our view of wound healing alterations during aging, diabetes, and fibrous disease and create novel therapeutic strategies for wound repair.
Identifiants
pubmed: 34445709
pii: ijms22169006
doi: 10.3390/ijms22169006
pmc: PMC8396603
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Human Frontier Science Program
ID : CDA00017/2016
Organisme : Deutsche Forschungsgemeinschaft
ID : RI 2787 / 1-1 AOBJ: 628819
Organisme : Fritz Thyssen Stiftung
ID : 2016-01277
Organisme : Else Kröner-Fresenius-Stiftung
ID : 2016_A21
Organisme : European Research Council
ID : ERC-CoG 819933
Pays : International
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