The Role of Biomarkers in Atherothrombotic Stroke-A Systematic Review.
atherosclerosis
atherothrombotic
biomarkers
stroke
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Aug 2021
21 Aug 2021
Historique:
received:
13
07
2021
revised:
18
08
2021
accepted:
20
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Stroke represents the primary debilitating disease in adults and is the second-highest cause of death worldwide. Atherosclerosis, the most prevalent etiology for vascular conditions, is a continuous process that gradually creates and develops endothelial lesions known as atherosclerotic plaques. These lesions lead to the appearance of atherothrombotic stroke. In the last decades, the role of biological biomarkers has emerged as either diagnostic, prognostic, or therapeutic targets. This article aims to create a list of potential biomarkers related to atherothrombotic stroke by reviewing the currently available literature. We identified 23 biomarkers and assessed their roles as risk factors, detection markers, prognostic predictors, and therapeutic targets. The central aspect of these biomarkers is related to risk stratification, especially for patients who have not yet suffered a stroke. Other valuable data are focused on the predictive capabilities for stroke patients regarding short-term and long-term prognosis, including their influence over the acute phase treatment, such as rt-PA thrombolysis. Although the role of biomarkers is anticipated to be of extreme value in the future, they cannot yet compete with traditional stroke neuroimaging markers but could be used as additional tools for etiological diagnosis.
Identifiants
pubmed: 34445740
pii: ijms22169032
doi: 10.3390/ijms22169032
pmc: PMC8396595
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Références
Acta Neurol Scand. 2009 Mar;119(3):141-50
pubmed: 18705677
Stroke. 2013 Jan;44(1):3-8
pubmed: 23192755
Neurol Res. 2019 Jun;41(6):498-503
pubmed: 30931822
J Clin Neurosci. 2014 Sep;21(9):1586-90
pubmed: 24814858
JAMA. 1994 Apr 13;271(14):1077; author reply 1078
pubmed: 8151843
Nat Clin Pract Cardiovasc Med. 2008 Oct;5(10):621-35
pubmed: 18711404
Rev Neurosci. 2017 Apr 1;28(3):295-306
pubmed: 28121618
Circ Res. 2021 Jan 22;128(2):284-286
pubmed: 33210556
Prague Med Rep. 2006;107(1):37-45
pubmed: 16752802
Int J Gen Med. 2016 Dec 14;9:447-452
pubmed: 28008280
BMC Neurol. 2012 Sep 24;12:102
pubmed: 23007013
PLoS Med. 2009 Sep;6(9):e1000145
pubmed: 19901973
J Investig Med. 2017 Apr;65(4):794-799
pubmed: 28193703
Lancet Neurol. 2005 Jun;4(6):371-80
pubmed: 15907742
Atherosclerosis. 2015 Oct;242(2):496-503
pubmed: 26298741
Mol Neurobiol. 2018 Apr;55(4):2952-2958
pubmed: 28456936
Stroke. 2002 Oct;33(10):2459-64
pubmed: 12364738
J Neurol Sci. 2014 Mar 15;338(1-2):87-91
pubmed: 24380688
J Atheroscler Thromb. 2011;18(9):753-61
pubmed: 21566344
Front Neurol. 2020 Dec 09;11:594672
pubmed: 33362697
Arch Med Sci. 2015 Mar 16;11(1):115-21
pubmed: 25861297
Clin Chim Acta. 2018 May;480:126-137
pubmed: 29453968
Biofactors. 2011 Nov-Dec;37(6):413-20
pubmed: 22038756
Stroke. 2017 Jun;48(6):1463-1469
pubmed: 28487337
Clin Pharmacol Ther. 2001 Mar;69(3):89-95
pubmed: 11240971
Diabetes Res Clin Pract. 2009 May;84(2):179-86
pubmed: 19269054
Int J Mol Sci. 2017 May 05;18(5):
pubmed: 28475147
J Clin Diagn Res. 2016 Sep;10(9):OC29-OC31
pubmed: 27790489
Top Stroke Rehabil. 2017 Dec;24(8):614-618
pubmed: 28845746
Stroke. 1997 Sep;28(9):1710-6
pubmed: 9303013
Rev Esp Cardiol. 2006 Mar;59(3):247-58
pubmed: 16712749
Neurochem Int. 2018 Mar;114:99-107
pubmed: 29408288
Neuro Endocrinol Lett. 2012;33(6):603-7
pubmed: 23160233
Cerebrovasc Dis. 2009;28(1):26-32
pubmed: 19420919
Atherosclerosis. 2014 Oct;236(2):263-9
pubmed: 25108075
Stroke. 2021 Jan;52(2):543-551
pubmed: 33430636
J Stroke Cerebrovasc Dis. 2017 May;26(5):1061-1070
pubmed: 28189572
Blood. 2009 Mar 26;113(13):2878-87
pubmed: 19008457
Cardiovasc Diabetol. 2009 Nov 18;8:60
pubmed: 19922611
PLoS One. 2014 Jan 09;9(1):e83393
pubmed: 24416164
Gene. 2020 Aug 20;752:144786
pubmed: 32439379
Genet Mol Res. 2015 Jul 17;14(3):8091-9
pubmed: 26214492
Circulation. 2001 Jan 30;103(4):491-5
pubmed: 11157711
Cell Mol Life Sci. 2019 Aug;76(16):3117-3140
pubmed: 31165904
Acta Pharmacol Sin. 2018 Jul;39(7):1176-1188
pubmed: 29877321
Aging (Albany NY). 2018 Oct 13;10(10):2695-2708
pubmed: 30317225
PLoS One. 2015 Apr 20;10(4):e0124565
pubmed: 25893670
Eur J Neurol. 2010 Jan;17(1):45-51
pubmed: 19566899
Eur J Vasc Endovasc Surg. 2010 Jun;39(6):668-75
pubmed: 20399126
Stroke. 2018 Aug;49(8):1969-1976
pubmed: 29991657
J Atheroscler Thromb. 2017 Oct 1;24(10):1023-1030
pubmed: 28428451
Biomed Res Int. 2019 May 20;2019:8642784
pubmed: 31236414
Neuroreport. 2017 Apr 12;28(6):325-330
pubmed: 28272264
BMC Nephrol. 2012 Jun 11;13:37
pubmed: 22686733
Stroke. 2006 Jan;37(1):27-32
pubmed: 16306468
Stroke. 2001 Apr;32(4):917-24
pubmed: 11283392
Stroke. 2001 Nov;32(11):2575-9
pubmed: 11692019
Thromb Haemost. 2004 Dec;92(6):1342-8
pubmed: 15583743
Int J Stroke. 2020 Feb;15(2):122-131
pubmed: 31537182
Medicine (Baltimore). 2017 Dec;96(51):e9413
pubmed: 29390564
Neurol Sci. 2017 Jul;38(7):1167-1186
pubmed: 28417216
Eur J Clin Invest. 2021 Aug;51(8):e13558
pubmed: 33756002
Stroke. 2005 Sep;36(9):1915-9
pubmed: 16109902
Stroke. 1999 May;30(5):981-5
pubmed: 10229731
Acta Pharmacol Sin. 2018 Jul;39(7):1228-1236
pubmed: 29926842
Semin Thromb Hemost. 2017 Mar;43(2):191-199
pubmed: 27472428
Exp Ther Med. 2018 Dec;16(6):5253-5257
pubmed: 30542482
Atherosclerosis. 2017 Nov;266:1-7
pubmed: 28934604
Int J Mol Sci. 2020 Oct 15;21(20):
pubmed: 33076218
Exp Biol Med (Maywood). 2018 Feb;243(3):211-212
pubmed: 28927290
Cerebrovasc Dis. 2016;42(1-2):117-21
pubmed: 27088493
Ann Clin Transl Neurol. 2016 Jul 27;3(9):678-83
pubmed: 27648457
Stroke. 2013 Aug;44(8):2128-33
pubmed: 23788583
Curr Treat Options Cardiovasc Med. 2007 Jun;9(3):229-35
pubmed: 17601387
Neurology. 2017 Nov 14;89(20):2101-2107
pubmed: 29030456
Neurol Sci. 2017 May;38(5):811-817
pubmed: 28215036
Int Heart J. 2016;57(2):134-9
pubmed: 26973275
Medicine (Baltimore). 2020 Mar;99(12):e19467
pubmed: 32195946
Thromb Haemost. 2009 Oct;102(4):759-64
pubmed: 19806263
Stroke. 2000 Dec;31(12):3047-53
pubmed: 11108771
Stroke. 2020 Dec;51(12):3523-3530
pubmed: 33161846
Inflamm Res. 2010 May;59(5):323-34
pubmed: 20140694
BMC Med Genet. 2010 Mar 11;11:40
pubmed: 20222942
Clin Chim Acta. 2011 Jan 14;412(1-2):139-42
pubmed: 20883678
Br J Surg. 2002 Jun;89(6):680-94
pubmed: 12027977
Psychol Med. 2009 Jul;39(7):1201-9
pubmed: 19356259
Blood. 2001 May 15;97(10):3086-92
pubmed: 11342434
J Atheroscler Thromb. 2018 Sep 1;25(9):829-835
pubmed: 29398676
Am J Clin Nutr. 2016 Sep;104(3):790-6
pubmed: 27534645
Int J Environ Res Public Health. 2016 Jun 27;13(7):
pubmed: 27355961
Sci Rep. 2018 May 3;8(1):6993
pubmed: 29725064
Neurology. 2017 Aug 22;89(8):805-812
pubmed: 28747453
Clin Sci (Lond). 2009 Oct 26;118(3):187-94
pubmed: 19515015
J Am Coll Cardiol. 2019 Jul 9;74(1):54-66
pubmed: 31272552
Stroke. 2007 Jun;38(6):1959-66
pubmed: 17478739
Clin Biochem. 2014 Nov;47(16-17):187-91
pubmed: 25117449
Atherosclerosis. 2009 Apr;203(2):346-52
pubmed: 18789800
Interdiscip Sci. 2018 Dec;10(4):722-733
pubmed: 28488219
J Inflamm (Lond). 2015 Nov 04;12:61
pubmed: 26543408
Int J Clin Exp Pathol. 2015 Sep 01;8(9):11647-52
pubmed: 26617904
Atherosclerosis. 2020 Jan;293:42-48
pubmed: 31835040
Nat Rev Nephrol. 2017 Jun;13(6):368-380
pubmed: 28392564
Immunology. 1992 Dec;77(4):543-9
pubmed: 1283598
Mol Neurobiol. 2017 Jan;54(1):328-341
pubmed: 26742513
Cardiovasc Diabetol. 2019 Aug 14;18(1):105
pubmed: 31412946
Eur Heart J. 2020 Jun 21;41(24):2275-2284
pubmed: 31111151
Nat Med. 2019 Nov;25(11):1761-1771
pubmed: 31700184
J Biol Chem. 1991 Feb 5;266(4):2466-73
pubmed: 1703529
Atherosclerosis. 2011 Sep;218(1):181-7
pubmed: 21620406
BMC Neurol. 2009 Apr 28;9:18
pubmed: 19400931
Mol Neurobiol. 2017 Apr;54(3):1919-1926
pubmed: 26899574
J Clin Endocrinol Metab. 2004 Nov;89(11):5713-7
pubmed: 15531533
Stroke. 2016 Sep;47(9):2221-8
pubmed: 27491741
Metabolism. 2017 Apr;69:51-66
pubmed: 28285652
J Stroke Cerebrovasc Dis. 2017 Nov;26(11):2570-2578
pubmed: 28687421
Clin Chim Acta. 2007 Mar;378(1-2):78-85
pubmed: 17173885
Neurology. 2005 Aug 9;65(3):366-70
pubmed: 16087899
Iran J Basic Med Sci. 2018 Jul;21(7):701-708
pubmed: 30140409
Atherosclerosis. 2013 Oct;230(2):228-34
pubmed: 24075749
Cerebrovasc Dis. 2009;27(6):544-51
pubmed: 19390179
N Engl J Med. 1996 Jun 6;334(23):1526-9
pubmed: 8618609
Neuromolecular Med. 2015 Dec;17(4):385-90
pubmed: 26330106
Biochem Soc Trans. 2019 Apr 30;47(2):541-557
pubmed: 30837322
Metab Brain Dis. 2017 Apr;32(2):641-648
pubmed: 28093678
Adv Clin Exp Med. 2019 May;28(5):693-698
pubmed: 30170483
Stroke. 2013 Jul;44(7):2064-89
pubmed: 23652265
Int J Mol Sci. 2012 Nov 28;13(12):15983-6004
pubmed: 23443106
Atherosclerosis. 2015 Mar;239(1):101-8
pubmed: 25585029
Circ Res. 2016 Jun 24;119(1):142-58
pubmed: 27340273
Stroke. 2011 Jul;42(7):1813-20
pubmed: 21546486
Eur J Clin Invest. 2015 Nov;45(11):1184-91
pubmed: 26381386
Arterioscler Thromb Vasc Biol. 2000 Apr;20(4):1047-51
pubmed: 10764671
Clin Proteomics. 2017 Jul 12;14:27
pubmed: 28701906
Metab Brain Dis. 2017 Jun;32(3):667-673
pubmed: 28378106
Int J Clin Exp Med. 2014 Feb 15;7(2):400-4
pubmed: 24600495
Stroke Res Treat. 2018 Nov 27;2018:3238165
pubmed: 30598741
Atherosclerosis. 2009 Aug;205(2):561-7
pubmed: 19171342
Stroke. 2001 Jul;32(7):1481-6
pubmed: 11441189
J Clin Neurol. 2011 Jun;7(2):69-76
pubmed: 21779294
Oncotarget. 2017 Dec 18;9(2):2208-2219
pubmed: 29416765
Stroke. 2008 Dec;39(12):3372-7
pubmed: 18927459
Pharmacogenomics. 2010 May;11(5):675-84
pubmed: 20415560
Stroke. 2004 Jun;35(6):1421-5
pubmed: 15073383
Antioxid Redox Signal. 2017 May 10;26(14):814-831
pubmed: 27650279
Cerebrovasc Dis. 2012;33(2):150-8
pubmed: 22178747
Diabetes Care. 2008 Feb;31 Suppl 2:S194-201
pubmed: 18227485
Ann Clin Transl Neurol. 2019 Nov;6(11):2240-2250
pubmed: 31637872
Nat Immunol. 2011 Mar;12(3):204-12
pubmed: 21321594
Neuroreport. 2014 Mar 5;25(4):262-6
pubmed: 24356104
Int J Neurosci. 2014 Oct;124(10):707-16
pubmed: 24304146
Lancet. 2010 May 1;375(9725):1536-44
pubmed: 20435228
Stroke. 2017 Jan;48(1):36-42
pubmed: 27856951
J Neurol Sci. 2010 Mar 15;290(1-2):12-5
pubmed: 20060545
Int J Angiol. 2019 Mar;28(1):34-38
pubmed: 30880891
Exp Ther Med. 2013 May;5(5):1427-1433
pubmed: 23737893
Br J Neurosurg. 2019 Oct;33(5):504-507
pubmed: 30892950
Neurotox Res. 2020 Apr;37(4):956-964
pubmed: 32034697
Blood Coagul Fibrinolysis. 2020 Jul;31(5):303-309
pubmed: 32371663
Atherosclerosis. 2019 Oct;289:8-13
pubmed: 31437611
J Pharm Pharm Sci. 2019;22(1):142-149
pubmed: 31013014
Kidney Int. 2007 Oct;72(7):879-85
pubmed: 17667984