Differential Effects of Cerebellar Degeneration on Feedforward versus Feedback Control across Speech and Reaching Movements.
cerebellum
feedback control
feedforward control
limb control
motor control
speech
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
20 10 2021
20 10 2021
Historique:
received:
07
04
2021
revised:
12
08
2021
accepted:
13
08
2021
pubmed:
28
8
2021
medline:
24
11
2021
entrez:
27
8
2021
Statut:
ppublish
Résumé
Errors that result from a mismatch between predicted movement outcomes and sensory afference are used to correct ongoing movements through feedback control and to adapt feedforward control of future movements. The cerebellum has been identified as a critical part of the neural circuit underlying implicit adaptation across a wide variety of movements (reaching, gait, eye movements, and speech). The contribution of this structure to feedback control is less well understood. Although it has recently been shown in the speech domain that individuals with cerebellar degeneration produce larger online corrections for sensory perturbations than control participants, similar behavior has not been observed in other motor domains. Currently, comparisons across domains are limited by different population samples and potential ceiling effects in existing tasks. To assess the relationship between changes in feedforward and feedback control associated with cerebellar degeneration across motor domains, we evaluated adaptive (feedforward) and compensatory (feedback) responses to sensory perturbations in reaching and speech production in human participants of both sexes with cerebellar degeneration and neurobiologically healthy controls. As expected, the cerebellar group demonstrated impaired adaptation in both reaching and speech. In contrast, the groups did not differ in their compensatory response in either domain. Moreover, compensatory and adaptive responses in the cerebellar group were not correlated within or across motor domains. These results point to a general impairment in feedforward control with spared feedback control in cerebellar degeneration. However, the magnitude of feedforward impairments and potential changes in feedback-based control manifest in a domain-specific manner across individuals.
Identifiants
pubmed: 34446570
pii: JNEUROSCI.0739-21.2021
doi: 10.1523/JNEUROSCI.0739-21.2021
pmc: PMC8528499
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
8779-8789Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC017696
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS116883
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD055931
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090256
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC017091
Pays : United States
Informations de copyright
Copyright © 2021 the authors.
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