Effect of education on functional network edge efficiency in Alzheimer's disease.
Aged
Aged, 80 and over
Algorithms
Alzheimer Disease
/ physiopathology
Cognition
/ physiology
Cognitive Dysfunction
/ physiopathology
Dementia
/ physiopathology
Educational Status
Female
Gyrus Cinguli
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
/ methods
Male
Memory
/ physiology
Middle Aged
Models, Neurological
Nerve Net
/ physiopathology
Neuropsychological Tests
/ statistics & numerical data
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
26 08 2021
26 08 2021
Historique:
received:
09
03
2021
accepted:
29
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
9
11
2021
Statut:
epublish
Résumé
We investigated the effect of education on the edge efficiency in resting state functional networks (RSFNs) in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease dementia (ADD). We collected the data of 57 early aMCI, 141 late aMCI, 173 mild ADD, and 39 moderate-to-severe ADD patients. We used years of education as a proxy for cognitive reserve. We measured edge efficiency for each edge in RSFNs, and performed simple slope analyses to discover their associations with education level among the four groups. In the late aMCI, a sub-network that had hub nodes in the right middle frontal gyrus and the right posterior cingulate gyrus, showed a positive association between RSFN edge efficiency and education (threshold = 2.5, p = 0.0478). There was no negative effect of education on the RSFN edge efficiency. In the early aMCI, mild ADD, and moderate-to-severe ADD, there were no sub-networks showing positive or negative correlation between education and RSFN edge efficiency. There was a positive effect of higher education on RSFN edge efficiency in the late aMCI, but not in the early aMCI or ADD. This indicates that in late aMCI, those who have higher education level have greater ability to resist collapsed functional network.
Identifiants
pubmed: 34446742
doi: 10.1038/s41598-021-96361-0
pii: 10.1038/s41598-021-96361-0
pmc: PMC8390462
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17255Informations de copyright
© 2021. The Author(s).
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