B Cell-mediated Humoral Immunity in Chronic Hepatitis B Infection.
Antibody
B cell
Chronic hepatitis B (CHB)
T follicular helper (Tfh) cells
Therapeutics
Journal
Journal of clinical and translational hepatology
ISSN: 2225-0719
Titre abrégé: J Clin Transl Hepatol
Pays: United States
ID NLM: 101649815
Informations de publication
Date de publication:
28 Aug 2021
28 Aug 2021
Historique:
received:
03
02
2021
revised:
24
04
2021
accepted:
06
05
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
28
8
2021
Statut:
ppublish
Résumé
B cell-mediated humoral immunity plays a vital role in viral infections, including chronic hepatitis B virus (HBV) infection, which remains a critical global public health issue. Despite hepatitis B surface antigen-specific antibodies are essential to eliminate viral infections, the reduced immune functional capacity of B cells was identified, which was also correlated with chronic hepatitis B (CHB) progression. In addition to B cells, T follicular helper (Tfh) cells, which assist B cells to produce antibodies, might also be involved in the process of anti-HBV-specific antibody production. Here, we provide a comprehensive review of the role of various subsets of B cells and Tfh cells during CHB progression and discuss current novel treatment strategies aimed at restoring humoral immunity. Understanding the mechanism of dysregulated B cells and Tfh cells will facilitate the ultimate functional cure of CHB patients.
Identifiants
pubmed: 34447690
doi: 10.14218/JCTH.2021.00051
pii: JCTH.2021.00051
pmc: PMC8369012
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
592-597Informations de copyright
© 2021 Authors.
Déclaration de conflit d'intérêts
The authors have no conflict of interests related to this publication.
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