Synergistic Multimodal Cancer Therapy Using Glucose Oxidase@CuS Nanocomposites.
Animals
Antineoplastic Agents
/ chemistry
Cell Line, Tumor
Combined Modality Therapy
Copper
/ chemistry
Drug Therapy
Enzymes, Immobilized
/ chemistry
Glucose
/ chemistry
Glucose Oxidase
/ chemistry
Humans
Light
Male
Melanoma
/ drug therapy
Mice, Inbred BALB C
Mice, Nude
Nanocomposites
/ chemistry
Photothermal Therapy
Fenton reaction
cancer therapy
copper sulfide nanoparticles
glucose oxidase
starvation therapy
Journal
ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991
Informations de publication
Date de publication:
08 Sep 2021
08 Sep 2021
Historique:
pubmed:
28
8
2021
medline:
18
1
2022
entrez:
27
8
2021
Statut:
ppublish
Résumé
Multimodal nanotherapeutic cancer treatments are widely studied but are often limited by their costly and complex syntheses that are not easily scaled up. Herein, a simple formulation of glucose-oxidase-coated CuS nanoparticles was demonstrated to be highly effective for melanoma treatment, acting through a synergistic combination of glucose starvation, photothermal therapy, and synergistic advanced chemodynamic therapy enabled by near-infrared irradiation coupled with Fenton-like reactions that were enhanced by endogenous chloride.
Identifiants
pubmed: 34448397
doi: 10.1021/acsami.1c12235
doi:
Substances chimiques
Antineoplastic Agents
0
Enzymes, Immobilized
0
Copper
789U1901C5
Glucose Oxidase
EC 1.1.3.4
Glucose
IY9XDZ35W2
cupric sulfide
KL4YU612X7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM