Covid-19 post-infectious acute transverse myelitis responsive to corticosteroid therapy: report of two clinical cases.
Acute transverse myelitis
COVID-19
Coronavirus
Severe acute respiratory syndrome by coronavirus 2 (SARS-COV-2)
Journal
Journal of neurovirology
ISSN: 1538-2443
Titre abrégé: J Neurovirol
Pays: United States
ID NLM: 9508123
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
26
04
2021
accepted:
04
08
2021
revised:
28
07
2021
pubmed:
28
8
2021
medline:
25
11
2021
entrez:
27
8
2021
Statut:
ppublish
Résumé
SARS-COV-2 infection has affected millions of individuals with a wide range of clinical manifestations, including central and peripheral nervous systems through several mechanisms. A rare but potentially severe manifestation of this virus is transverse myelitis. Herein, we report on two patients who developed paraparesis, sensory deficit, and autonomic changes on the tenth day after infection by COVID-19. A 27-year-old man, previously healthy, had symptoms of COVID-19 confirmed by oropharyngeal and nasopharyngeal swab tests. On the tenth day of symptoms, the patient started to experience acute paraparesis, urinary retention, constipation, and hypoesthesia up to the T4 level. The second patient is a 50-year-old man, previously healthy, who had symptoms of the flu-like syndrome. The diagnosis of COVID-19 infection was confirmed by oropharyngeal and nasopharyngeal swab tests. On the tenth day of symptoms, the patient started to experience paraparesis, urinary incontinence, and hypoesthesia up to the T6 level. The neuroimaging and cerebrospinal fluid (CSF) analysis of both patients confirmed acute transverse myelitis after COVID-19 infection. High-dose corticosteroid therapy was started, and both patients showed rapid recovery from their deficits. Although rare, post-infectious transverse myelitis may be related to SARS-COV-2 infection and should be quickly recognized. Although controlled studies are needed, treatment with corticosteroid therapy in high doses was effective in these patients.
Identifiants
pubmed: 34449062
doi: 10.1007/s13365-021-01010-x
pii: 10.1007/s13365-021-01010-x
pmc: PMC8393787
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
791-796Subventions
Organisme : CAPES
ID : 88881.505364/2020-01
Organisme : conselho nacional de desenvolvimento científico e tecnológico
ID : Productivity scholarshipt
Informations de copyright
© 2021. Journal of NeuroVirology, Inc.
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