Smart Responsive Microarray Patches for Transdermal Drug Delivery and Biological Monitoring.


Journal

Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613

Informations de publication

Date de publication:
10 2021
Historique:
revised: 15 07 2021
received: 21 05 2021
pubmed: 28 8 2021
medline: 6 11 2021
entrez: 27 8 2021
Statut: ppublish

Résumé

Traditional drug delivery routes possess various disadvantages which make them unsuitable for certain population groups, or indeed unsuitable for drugs with certain physicochemical properties. As a result, a variety of alternative drug delivery routes have been explored in recent decades, including transdermal drug delivery. One of the most promising novel transdermal drug delivery technologies is a microarray patch (MAP), which can bypass the outermost skin barrier and deliver drugs directly into the viable epidermis and dermis. Unlike traditional MAPs which release loaded cargo simultaneously upon insertion into the skin, stimuli responsive MAPs based on biological stimuli are able to precisely release the drug in response to the need for additional doses. Thus, smart MAPs that are only responsive to certain external stimuli are highly desirable, as they provide safer and more efficient drug delivery. In addition to drug delivery, they can also be used for biological monitoring, which further expands their applications.

Identifiants

pubmed: 34449129
doi: 10.1002/adhm.202100996
doi:

Substances chimiques

Pharmaceutical Preparations 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2100996

Informations de copyright

© 2021 Wiley-VCH GmbH.

Références

a) R. F. Donnelly, T. R. R. Singh, A. D. Woolfson, Drug Delivery 2010, 17, 187;
b) A. Z. Alkilani, M. T. McCrudden, R. F. Donnelly, Pharmaceutics 2015, 7, 438;
c) E. M. Migdadi, A. J. Courtenay, I. A. Tekko, M. T. McCrudden, M.-C. Kearney, E. McAlister, H. O. McCarthy, R. F. Donnelly, J. Controlled Release 2018, 285, 142;
d) W. Li, R. N. Terry, J. Tang, M. R. Feng, S. P. Schwendeman, M. R. Prausnitz, Nat. Biomed. Eng. 2019, 3, 220;
e) W. Li, J. Tang, R. N. Terry, S. Li, A. Brunie, R. L. Callahan, R. K. Noel, C. A. Rodríguez, S. P. Schwendeman, M. R. Prausnitz, Sci. Adv. 2019, 5, eaaw8145;
f) S. Abdelghany, I. A. Tekko, L. Vora, E. Larrañeta, A. D. Permana, R. F. Donnelly, Pharmaceutics 2019, 11, 308.
R. F. Donnelly, E. Larraňeta, Nat. Biomed. Eng. 2019, 3, 169.
R. Mishra, T. K. Maiti, T. K. Bhattacharyya, IEEE Sens. J. 2018, 18, 5635.
A. J. Paredes, P. E. McKenna, I. K. Ramöller, Y. A. Naser, F. Volpe-Zanutto, M. Li, M. Abbate, L. Zhao, C. Zhang, J. M. Abu-Ershaid, Adv. Funct. Mater. 2020, 31, 2005792.
D. Ramadon, A. D. Permana, A. J. Courtenay, M. T. McCrudden, I. A. Tekko, E. McAlister, Q. K. Anjani, E. Utomo, H. O. McCarthy, R. F. Donnelly, Mol. Pharmaceutics 2020, 17, 3353.
a) D.-S. Kim, J.-T. Choi, C. B. Kim, Y.-R. Shin, P.-g. Park, H. Kim, J. M. Lee, J.-H. Park, Pharm. Res. 2020, 37, 50;
b) R. F. Donnelly, E. Larrañeta, Drug Discovery Today 2018, 23, 1026.
M. R. Prausnitz, J. L. Goodson, P. A. Rota, W. A. Orenstein, Curr. Opin. Virol. 2020, 41, 68.
R. Wong, V. Tran, V. Morhenn, S.-p. Hung, B. Andersen, E. Ito, G. W. Hatfield, N. R. Benson, J. Invest. Dermatol. 2004, 123, 159.
a) L. Wei-Ze, H. Mei-Rong, Z. Jian-Ping, Z. Yong-Qiang, H. Bao-Hua, L. Ting, Z. Yong, Int. J. Pharm. 2010, 389, 122;
b) C. S. Kolli, A. K. Banga, Pharm. Res. 2008, 25, 104.
a) M. Dul, M. Stefanidou, P. Porta, J. Serve, C. O'Mahony, B. Malissen, S. Henri, Y. Levin, E. Kochba, F. S. Wong, J. Controlled Release 2017, 265, 120;
b) L. Daugimont, N. Baron, G. Vandermeulen, N. Pavselj, D. Miklavcic, M.-C. Jullien, G. Cabodevila, L. M. Mir, V. Préat, J. Membr. Biol. 2010, 236, 117.
a) D. G. Koutsonanos, M. del Pilar Martin, V. G. Zarnitsyn, S. P. Sullivan, R. W. Compans, M. R. Prausnitz, I. Skountzou, PLoS One 2009, 4, e4773;
b) M. Cormier, B. Johnson, M. Ameri, K. Nyam, L. Libiran, D. D. Zhang, P. Daddona, J. Controlled Release 2004, 97, 503.
a) S. P. Sullivan, D. G. Koutsonanos, M. del Pilar Martin, J. W. Lee, V. Zarnitsyn, S.-O. Choi, N. Murthy, R. W. Compans, I. Skountzou, M. R. Prausnitz, Nat. Med. 2010, 16, 915;
b) M. Zaric, O. Lyubomska, C. Poux, M. L. Hanna, M. T. McCrudden, B. Malissen, R. J. Ingram, U. F. Power, C. J. Scott, R. F. Donnelly, J. Invest. Dermatol. 2015, 135, 425.
a) R. F. Donnelly, M. T. McCrudden, A. Z. Alkilani, E. Larrañeta, E. McAlister, A. J. Courtenay, M.-C. Kearney, T. R. R. Singh, H. O. McCarthy, V. L. Kett, PLoS One 2014, 9, e111547;
b) E. Larraneta, R. E. Lutton, A. J. Brady, E. M. Vicente-Pérez, A. D. Woolfson, R. R. S. Thakur, R. F. Donnelly, Macromol. Mater. Eng. 2015, 300, 586.
a) L. K. Vora, R. F. Donnelly, E. Larrañeta, P. González-Vázquez, R. R. S. Thakur, P. R. Vavia, J. Controlled Release 2017, 265, 93;
b) A. J. Courtenay, E. McAlister, M. T. McCrudden, L. Vora, L. Steiner, G. Levin, E. Levy-Nissenbaum, N. Shterman, M.-C. Kearney, H. O. McCarthy, J. Controlled Release 2020, 322, 177.
A. S. Cordeiro, I. A. Tekko, M. H. Jomaa, L. Vora, E. McAlister, F. Volpe-Zanutto, M. Nethery, P. T. Baine, N. Mitchell, D. W. McNeill, Pharm. Res. 2020, 37, 174.
R. Al-Kasasbeh, A. J. Brady, A. J. Courtenay, E. Larrañeta, M. T. McCrudden, D. O'Kane, S. Liggett, R. F. Donnelly, Drug Delivery Transl. Res. 2020, 10, 690
E. Larraneta, R. E. Lutton, A. D. Woolfson, R. F. Donnelly, Mater. Sci. Eng., R 2016, 104, 1.
B. Tian, S. Liu, S. Wu, W. Lu, D. Wang, L. Jin, B. Hu, K. Li, Z. Wang, Z. Quan, Colloids Surf., B 2017, 154, 287.
B. Wang, R. Ma, G. Liu, Y. Li, X. Liu, Y. An, L. Shi, Langmuir 2009, 25, 12522.
M. Tanihara, Y. Suzuki, Y. Nishimura, K. Suzuki, Y. Kakimaru, Peptides 1998, 19, 421.
a) R. F. Donnelly, K. Mooney, E. Caffarel-Salvador, B. M. Torrisi, E. Eltayib, J. C. McElnay, Ther. Drug Monit. 2014, 36, 10;
b) P. M. Wang, M. Cornwell, M. R. Prausnitz, Diabetes Technol. Ther. 2005, 7, 131.
A. V. Mohan, J. R. Windmiller, R. K. Mishra, J. Wang, Biosens. Bioelectron. 2017, 91, 574.
F. B. Hu, Diabetes Care 2011, 34, 1249.
X. Jin, D. D. Zhu, B. Z. Chen, M. Ashfaq, X. D. Guo, Adv. Drug Delivery Rev. 2018, 127, 119.
Z. Tong, J. Zhou, J. Zhong, Q. Tang, Z. Lei, H. Luo, P. Ma, X. Liu, ACS Appl. Mater. Interfaces 2018, 10, 20014.
S. P. Davis, W. Martanto, M. G. Allen, M. R. Prausnitz, IEEE Trans. Biomed. Eng. 2005, 52, 909.
M.-H. Ling, M.-C. Chen, Acta Biomater. 2013, 9, 8952.
G. Chen, J. Yu, Z. Gu, J. Diabetes Sci. Technol. 2019, 13, 41.
J. Yu, Y. Zhang, Y. Ye, R. DiSanto, W. Sun, D. Ranson, F. S. Ligler, J. B. Buse, Z. Gu, Proc. Natl. Acad. Sci. USA 2015, 112, 8260.
J. Pickup, Trends Biotechnol. 1993, 11, 285.
Y. Ye, J. Yu, C. Wang, N. Y. Nguyen, G. M. Walker, J. B. Buse, Z. Gu, Adv. Mater. 2016, 28, 3115.
X. Hu, J. Yu, C. Qian, Y. Lu, A. R. Kahkoska, Z. Xie, X. Jing, J. B. Buse, Z. Gu, ACS Nano 2017, 11, 613.
M. A. Luzuriaga, R. P. Welch, M. Dharmarwardana, C. E. Benjamin, S. Li, A. Shahrivarkevishahi, S. Popal, L. H. Tuong, C. T. Creswell, J. J. Gassensmith, ACS Appl. Mater. Interfaces 2019, 11, 9740.
Z. Xu, G. Xiao, H. Li, Y. Shen, J. Zhang, T. Pan, X. Chen, B. Zheng, J. Wu, S. Li, Adv. Funct. Mater. 2018, 28, 1802479.
X. Wu, C. Yang, J. Ge, Z. Liu, Nanoscale 2015, 7, 18883.
F.-S. Liao, W.-S. Lo, Y.-S. Hsu, C.-C. Wu, S.-C. Wang, F.-K. Shieh, J. V. Morabito, L.-Y. Chou, K. C.-W. Wu, C.-K. Tsung, J. Am. Chem. Soc. 2017, 139, 6530.
X.-X. Yang, P. Feng, J. Cao, W. Liu, Y. Tang, ACS Appl. Mater. Interfaces 2020, 12, 13613.
S. Chen, H. Matsumoto, Y. Moro-oka, M. Tanaka, Y. Miyahara, T. Suganami, A. Matsumoto, Adv. Funct. Mater. 2019, 29, 1807369.
W. Chen, R. Tian, C. Xu, B. C. Yung, G. Wang, Y. Liu, Q. Ni, F. Zhang, Z. Zhou, J. Wang, Nat. Commun. 2017, 8, 1.
P. E. Cryer, S. N. Davis, H. Shamoon, Diabetes Care 2003, 26, 1902.
A. GhavamiNejad, J. Li, B. Lu, L. Zhou, L. Lam, A. Giacca, X. Y. Wu, Adv. Mater. 2019, 31, 1901051.
A. El-Laboudi, N. S. Oliver, A. Cass, D. Johnston, Diabetes Technol. Ther. 2013, 15, 101.
Y. Yoon, G. S. Lee, K. Yoo, J. B. Lee, Sensors 2013, 13, 16672.
a) V. Lodwig, B. Kulzer, O. Schnell, L. Heinemann, J. Diabetes Sci. Technol. 2014, 8, 390;
b) D. Rodbard, Diabetes Technol. Ther. 2016, 18, S3.
K. Takeuchi, B. Kim, Nano Convergence 2018, 5, 28.
a) Y. C. Kim, J. H. Park, M. R. Prausnitz, Adv. Drug Delivery Rev. 2012, 64, 1547;
b) L. Xie, H. Zeng, J. Sun, W. Qian, Micromachines 2020, 11, 271.
K. Tsuchiya, N. Nakanishi, Y. Uetsuji, E. Nakamachi, Biomed. Microdevices 2005, 7, 347.
D. M. S. M. S. Boyne, J. Kaplan, C. D. Saudek, Diabetes 2003, 52, 2790.
a) E. Caffarel-Salvador, A. J. Brady, E. Eltayib, T. Meng, A. Alonso-Vicente, P. Gonzalez-Vazquez, B. M. Torrisi, E. M. Vicente-Perez, K. Mooney, D. S. Jones, S. E. Bell, C. P. McCoy, H. O. McCarthy, J. C. McElnay, R. F. Donnelly, PLoS One 2015, 10, 1;
b) H. Chang, M. Zheng, X. Yu, A. Than, R. Z. Seeni, R. Kang, J. Tian, D. P. Khanh, L. Liu, P. Chen, C. Xu, Adv. Mater. 2017, 29, 1702243.
a) E. V. Mukerjee, S. D. Collins, R. R. Isseroff, R. L. Smith, Sens. Actuators, A 2004, 114, 267;
b) B. Chua, S. P. Desai, M. J. Tierney, J. A. Tamada, A. N. Jina, Sens. Actuators, A 2013, 203, 373;
c) L. M. Strambini, A. Longo, S. Scarano, T. Prescimone, I. Palchetti, M. Minunni, D. Giannessi, G. Barillaro, Biosens. Bioelectron. 2015, 66, 162;
d) D. Nicholas, K. A. Logan, Y. Sheng, J. Gao, S. Farrell, D. Dixon, B. Callan, A. P. McHale, J. F. Callan, Int. J. Pharm. 2018, 547, 244.
P. Bollella, S. Sharma, A. E. G. Cass, F. Tasca, R. Antiochia, Catalysts 2019, 9, 580.
M. T. Y. Ito, A. Hayashi, M. Anai, S. Morita, E. Ko, N. Yoshimoto, Y. Yoshii, S. Kobuchi, T. Sakaeda, K. Takadab, Biol. Pharm. Bull. 2014, 37, 1776.
a) M. A. Invernale, B. C. Tang, R. L. York, L. Le, D. Y. Hou, D. G. Anderson, Adv. Healthcare Mater. 2014, 3, 338;
b) D. Chen, C. Wang, W. Chen, Y. Chen, J. X. Zhang, Biosens. Bioelectron. 2015, 74, 1047;
c) A. Caliò, P. Dardano, V. Di Palma, M. F. Bevilacqua, A. Di Matteo, H. Iuele, L. De Stefano, Sens. Actuators, B 2016, 236, 343;
d) S. J. Lee, H. S. Yoon, X. Xuan, J. Y. Park, S.-J. Paik, M. G. Allen, Sens. Actuators, B 2016, 222, 1144;
e) S. Sharma, Z. Huang, M. Rogers, M. Boutelle, A. E. Cass, Anal. Bioanal. Chem. 2016, 408, 8427;
f) S. R. Chinnadayyala, I. Park, S. Cho, Microchim. Acta 2018, 185, 250;
g) J. Gao, W. Huang, Z. Chen, C. Yi, L. Jiang, Sens. Actuators, B 2019, 287, 102;
h) K. B. Kim, W.-C. Lee, C.-H. Cho, D.-S. Park, S. J. Cho, Y.-B. Shim, Sens. Actuators, B 2019, 281, 14.
J. D. Zahn, D. Trebotich, D. Liepmann, Biomed. Microdevices 2005, 7, 59.
a) F. Ribet, G. Stemme, N. Roxhed, 2018 IEEE Micro Electro Mechanical Systems (MEMS), 2018, 408;
b) G. Valdés-Ramírez, Y.-C. Li, J. Kim, W. Jia, A. J. Bandodkar, R. Nuñez-Flores, P. R. Miller, S.-Y. Wu, R. Narayan, J. R. Windmiller, R. Polsky, J. Wang, Electrochem. Commun. 2014, 47, 58.
Y. Li, H. Zhang, R. Yang, Y. Laffitte, U. Schmill, W. Hu, M. Kaddoura, E. J. M. Blondeel, B. Cui, Microsyst. Nanoeng. 2019, 5, 41.
S. Park, H. Boo, T. D. Chung, Anal. Chim. Acta 2006, 556, 46.
N. Mackman, Nature 2008, 451, 914.
a) B. Engelmann, S. Massberg, Nat. Rev. Immunol. 2013, 13, 34;
b) N. Doshi, J. N. Orje, B. Molins, J. W. Smith, S. Mitragotri, Z. M. Ruggeri, Adv. Mater. 2012, 24, 3864;
c) Q. Hu, C. Qian, W. Sun, J. Wang, Z. Chen, H. N. Bomba, H. Xin, Q. Shen, Z. Gu, Adv. Mater. 2016, 28, 9573.
a) P. M. Mannucci, M. Franchini, Ann. Med. 2011, 43, 116;
b) W. H. Geerts, D. Bergqvist, G. F. Pineo, J. A. Heit, C. M. Samama, M. R. Lassen, C. W. Colwell, Chest 2008, 133, 381S.
a) L. Jin, J. Abrahams, R. Skinner, M. Petitou, R. Pike, R. Carrell, Proc. Natl. Acad. Sci. U. S. A. 1997, 94, 14683;
b) R. Collins, A. Scrimgeour, S. Yusuf, R. Peto, N. Engl. J. Med. 1988, 318, 1162.
a) M. Cohen, C. Demers, E. P. Gurfinkel, A. G. G. Turpie, G. J. Fromell, S. Goodman, A. Langer, R. M. Califf, K. A. A. Fox, J. Premmereur, F. Bigonzi, J. Stephens, B. Weatherley, N. Engl. J. Med. 1997, 337, 447;
b) P. Prandoni, A. W. A. Lensing, A. Piccioli, E. Bernardi, P. Simioni, B. Girolami, A. Marchiori, P. Sabbion, M. H. Prins, F. Noventa, A. Girolami, Blood 2002, 100, 3484.
Y. Zhang, J. Yu, J. Wang, N. J. Hanne, Z. Cui, C. Qian, C. Wang, H. Xin, J. H. Cole, C. M. Gallippi, Y. Zhu, Z. Gu, Adv. Mater. 2017, 29, 1604043.
B. Dahlbäck, Lancet 2000, 355, 1627.
a) J.-Y. Chang, Eur. J. Biochem. 1985, 151, 217;
b) G. Kogan, L. Soltes, R. Stern, P. Gemeiner, Biotechnol. Lett. 2007, 29, 17.
J. G. Hardy, E. Larrañeta, R. F. Donnelly, N. McGoldrick, K. Migalska, M. T. McCrudden, N. J. Irwin, L. Donnelly, C. P. McCoy, Mol. Pharmaceutics 2016, 13, 907.
Y. Hao, M. Dong, T. Zhang, J. Peng, Y. Jia, Y. Cao, Z. Qian, ACS Appl. Mater. Interfaces 2017, 9, 15317.
C. P. McCoy, C. Rooney, C. R. Edwards, D. S. Jones, S. P. Gorman, J. Am. Chem. Soc. 2007, 129, 9572.
G. Yang, J. Liu, Y. Wu, L. Feng, Z. Liu, Coord. Chem. Rev. 2016, 320, 100.
a) M.-C. Chen, K.-W. Wang, D.-H. Chen, M.-H. Ling, C.-Y. Liu, Acta Biomater. 2015, 13, 344;
b) M.-C. Chen, M.-H. Ling, K.-W. Wang, Z.-W. Lin, B.-H. Lai, D.-H. Chen, Biomacromolecules 2015, 16, 1598;
c) M.-C. Chen, Z.-W. Lin, M.-H. Ling, ACS Nano 2016, 10, 93.
D. Liu, Y. Zhang, G. Jiang, W. Yu, B. Xu, J. Zhu, ACS Biomater. Sci. Eng. 2018, 4, 1687.
Y. Zhang, D. Wang, M. Gao, B. Xu, J. Zhu, W. Yu, D. Liu, G. Jiang, ACS Biomater. Sci. Eng. 2018, 4, 2879.
A. Anderson, C. Hegarty, C. Casimero, J. Davis, ACS Appl. Mater. Interfaces 2019, 11, 35540.
X. Lan, J. She, D.-a. Lin, Y. Xu, X. Li, W.-f. Yang, V. W. Y. Lui, L. Jin, X. Xie, Y.-x. Su, ACS Appl. Mater. Interfaces 2018, 10, 33060.
C.-J. Ke, Y.-J. Lin, Y.-C. Hu, W.-L. Chiang, K.-J. Chen, W.-C. Yang, H.-L. Liu, C.-C. Fu, H.-W. Sung, Biomaterials 2012, 33, 5156.
K. van der Maaden, E. Sekerdag, P. Schipper, G. Kersten, W. Jiskoot, J. Bouwstra, Langmuir 2015, 31, 8654.
P. Schipper, K. van der Maaden, V. Groeneveld, M. Ruigrok, S. Romeijn, S. Uleman, C. Oomens, G. Kersten, W. Jiskoot, J. Bouwstra, J. Controlled Release 2017, 262, 28.
N. W. Kim, M. S. Lee, K. R. Kim, J. E. Lee, K. Lee, J. S. Park, Y. Matsumoto, D.-G. Jo, H. Lee, D. S. Lee, J. Controlled Release 2014, 179, 11.
H. T. T. Duong, Y. Yin, T. Thambi, T. L. Nguyen, V. G. Phan, M. S. Lee, J. E. Lee, J. Kim, J. H. Jeong, D. S. Lee, Biomaterials 2018, 185, 13.
Y. He, C. Hong, J. Li, M. T. Howard, Y. Li, M. E. Turvey, D. S. Uppu, J. R. Martin, K. Zhang, D. J. Irvine, ACS Nano 2018, 12, 10272.
a) Y. Marunaka, Int. J. Mol. Sci. 2018, 19, 3244;
b) Y. Marunaka, World J. Diabetes 2015, 6, 125.
a) G. Baronzio, L. Schwartz, M. Kiselevsky, A. Guais, E. Sanders, G. Milanesi, M. Baronzio, I. Freitas, Anticancer Res. 2012, 32, 405;
b) R. K. Jain, S. A. Shah, P. L. Finney, JNCI, J. Natl. Cancer Inst. 1984, 73, 429.
J. E. Park, N. Yonet-Tanyeri, E. V. Ende, A.-I. Henry, B. E. P. White, M. Mrksich, R. P. Van Duyne, Nano Lett. 2019, 19, 6862.
C. Zuliani, F. S. Ng, A. Alenda, A. Eftekhar, N. S. Peters, C. Toumazou, Analyst 2016, 141, 4659.
K. B. Mirza, C. Zuliani, B. Hou, F. S. Ng, N. S. Peters, C. Toumazou, presented at 2017 39th Annual Int. Conf. of the IEEE Engineering in Medicine and Biology Society (EMBC), Jeju Island, Korea, July 11-15, 2017.
H. Zhou, G. Li, X. Sun, Z. Zhu, B. Xu, Q. Jin, J. Zhao, Q.-S. Ren, Sens. Actuators, A 2009, 150, 296.
M. Wu, Y. Zhang, H. Huang, J. Li, H. Liu, Z. Guo, L. Xue, S. Liu, Y. Lei, Mater. Sci. Eng., C 2020, 117, 111299.
A. Kundu, P. Arnett, A. Bagde, N. Azim, E. Kouagou, M. Singh, S. Rajaraman, J. Microelectromech. Syst. 2020, 29, 685.

Auteurs

Li Zhao (L)

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Chunyang Zhang (C)

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Juhaina M Abu-Ershaid (JM)

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Mingshan Li (M)

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Yaocun Li (Y)

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Yara Naser (Y)

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Xianbing Dai (X)

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Marco T A Abbate (MTA)

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Ryan F Donnelly (RF)

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Articles similaires

Humans Pharmaceutical Preparations Drug Utilization Prescription Drugs
Vancomycin Polyesters Anti-Bacterial Agents Models, Theoretical Drug Liberation
Humans Acne Vulgaris Dapsone Female Male
Rivers Turkey Biodiversity Environmental Monitoring Animals

Classifications MeSH