Mechanical competition alters the cellular interpretation of an endogenous genetic program.
Journal
The Journal of cell biology
ISSN: 1540-8140
Titre abrégé: J Cell Biol
Pays: United States
ID NLM: 0375356
Informations de publication
Date de publication:
01 11 2021
01 11 2021
Historique:
received:
24
04
2021
revised:
26
07
2021
accepted:
30
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
The intrinsic genetic program of a cell is not sufficient to explain all of the cell's activities. External mechanical stimuli are increasingly recognized as determinants of cell behavior. In the epithelial folding event that constitutes the beginning of gastrulation in Drosophila, the genetic program of the future mesoderm leads to the establishment of a contractile actomyosin network that triggers apical constriction of cells and thereby tissue folding. However, some cells do not constrict but instead stretch, even though they share the same genetic program as their constricting neighbors. We show here that tissue-wide interactions force these cells to expand even when an otherwise sufficient amount of apical, active actomyosin is present. Models based on contractile forces and linear stress-strain responses do not reproduce experimental observations, but simulations in which cells behave as ductile materials with nonlinear mechanical properties do. Our models show that this behavior is a general emergent property of actomyosin networks in a supracellular context, in accordance with our experimental observations of actin reorganization within stretching cells.
Identifiants
pubmed: 34449835
pii: 212605
doi: 10.1083/jcb.202104107
pmc: PMC8406609
pii:
doi:
Substances chimiques
Actins
0
Drosophila Proteins
0
Actomyosin
9013-26-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021 Bhide et al.
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