Early Atherosclerotic Inflammatory Pathways in Children with Obstructive Sleep Apnea.
Acute-Phase Proteins
/ metabolism
Adolescent
Atherosclerosis
/ blood
Biomarkers
/ blood
Carotid Artery, Common
/ diagnostic imaging
Case-Control Studies
Child
Child, Preschool
Cross-Sectional Studies
Cytokines
/ blood
Female
Humans
Inflammation
/ blood
Linear Models
Male
Prospective Studies
Sleep Apnea, Obstructive
/ blood
Ultrasonography
cardiovascular disease
carotid intima media thickness
inflammation
obstructive sleep apnea syndrome
pediatric OSA
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
24
03
2021
revised:
15
07
2021
accepted:
18
08
2021
pubmed:
28
8
2021
medline:
4
1
2022
entrez:
27
8
2021
Statut:
ppublish
Résumé
To evaluate structural and functional carotid changes and inflammatory profiles in children with obstructive sleep apnea (OSA) and healthy controls. Patients with OSA and matched controls (ages 5-13 years) were recruited. Proinflammatory cytokines and acute phase reactants were measured at 6:00 p.m. Common carotid artery measures were determined using ultrasound. Confirmatory factor analysis was used to determine subgroups of cytokines and their effects on carotid measures. Ninety-six patients participated (53 healthy controls, 43 patients with OSA). OSA was associated with increased proinflammatory cytokines (cluster of differentiation-40 ligand [CD40-L], interleukin [IL]-6, and IL-8) and high sensitivity C-reactive protein (P < .05 for all). One cytokine subgroup (IL-6 and IL-8) was negatively associated with markers of carotid function, indicating reduced arterial distensibility and increased stiffness (P < .05 for 3 ultrasound measures); and tumor necrosis factor-α had an opposing effect on carotid function compared with this cytokine subgroup (P < .05 for 2 ultrasound measures). Linear regression demonstrated significant associations between and tumor necrosis factor- α and 2 measures of carotid function (P < .05 for each). Children with OSA did not have functional or structural carotid changes compared with controls. OSA was not directly associated with structural and functional carotid changes but was associated with upregulation of key proinflammatory cytokines (sCD40-L, IL-6, and IL-8). Together, IL-6 and IL-8 were associated with changes in carotid function. Longitudinal studies are needed to demonstrate that the inflammatory milieu observed in our population is a precursor of atherosclerosis in children.
Identifiants
pubmed: 34450122
pii: S0022-3476(21)00792-7
doi: 10.1016/j.jpeds.2021.08.031
pmc: PMC9020582
mid: NIHMS1735984
pii:
doi:
Substances chimiques
Acute-Phase Proteins
0
Biomarkers
0
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
168-174Subventions
Organisme : NHLBI NIH HHS
ID : K08 HL148551
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL080670
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Références
Chest. 2011 Aug;140(2):534-542
pubmed: 21813534
Clin Auton Res. 1999 Dec;9(6):345-51
pubmed: 10638809
Hypertension. 1990 Apr;15(4):339-47
pubmed: 2180816
Sleep. 2004 Feb 1;27(1):129-33
pubmed: 14998249
Sleep. 2009 Oct;32(10):1265-71
pubmed: 19848356
Sleep. 1997 Feb;20(2):151-7
pubmed: 9143075
Sleep. 2012 Oct 01;35(10):1335-43
pubmed: 23024431
Am J Cardiol. 2005 Mar 15;95(6):801-4
pubmed: 15757619
N Engl J Med. 2005 Nov 10;353(19):2034-41
pubmed: 16282178
J Clin Sleep Med. 2013 Oct 15;9(10):1003-12
pubmed: 24127144
Sleep. 2017 Apr 1;40(4):
pubmed: 28204724
Int J Obes (Lond). 2015 Jul;39(7):1086-93
pubmed: 25913504
Lung. 2014 Apr;192(2):297-303
pubmed: 24469113
Am J Respir Crit Care Med. 2005 Sep 1;172(5):613-8
pubmed: 15901608
Circulation. 2003 Nov 11;108(19):2317-22
pubmed: 14568895
Int J Clin Exp Med. 2015 Mar 15;8(3):4731-43
pubmed: 26064414
Sleep Breath. 2012 Sep;16(3):695-701
pubmed: 21796489
Ann Med. 2011 Aug;43(5):331-40
pubmed: 21244217
J Am Coll Cardiol. 1995 Jan;25(1):83-90
pubmed: 7798531
Circulation. 2000 May 9;101(18):2149-53
pubmed: 10801754
Hypertension. 2008 Jan;51(1):84-91
pubmed: 18071053
Chest. 2015 Apr;147(4):1029-1036
pubmed: 25429400
Hypertension. 2016 Nov;68(5):1264-1270
pubmed: 27620392
World J Pediatr. 2016 Feb;12(1):103-8
pubmed: 26684310
Hypertension. 2009 Nov;54(5):919-50
pubmed: 19729599
Thromb Haemost. 2003 Sep;90(3):377-84
pubmed: 12958605
Circulation. 2010 Jul 27;122(4):352-60
pubmed: 20625114
Biochem Res Int. 2015;2015:984193
pubmed: 26697221
Am J Respir Crit Care Med. 2005 Sep 1;172(5):625-30
pubmed: 16120716
Angiology. 2017 Aug;68(7):575-583
pubmed: 27581069
Circulation. 2009 Jun 9;119(22):2913-9
pubmed: 19470890
Clin Cardiol. 2012 Oct;35(10):641-5
pubmed: 22949086
J Appl Physiol (1985). 2003 Jan;94(1):179-84
pubmed: 12391099
J Clin Sleep Med. 2013 May 15;9(5):493-8
pubmed: 23674941
Sleep. 2017 Sep 1;40(9):
pubmed: 28934533
Am J Respir Crit Care Med. 1998 Apr;157(4 Pt 1):1098-103
pubmed: 9563725