Polyenvironmental and polygenic risk scores and the emergence of psychotic experiences in adolescents.

Adolescent Genetic Predisposition to Disease Hallucinations Humans Multifactorial Inheritance / genetics Psychotic Disorders / epidemiology Risk Factors Schizophrenia / epidemiology
Environmental PERS PRS Polyenvironmental risk score Polygenic risk score Psychotic experiences

Journal

Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331

Informations de publication

Date de publication:
10 2021
Historique:
received: 02 03 2021
revised: 15 07 2021
accepted: 31 07 2021
pubmed: 28 8 2021
medline: 30 10 2021
entrez: 27 8 2021
Statut: ppublish

Résumé

Psychotic experiences (PE) are forms of hallucinations and delusions neither reaching the intensity and functional impairment required to be regarded as full psychotic symptoms nor a psychotic disorder. Here we investigated the ability to predict PE using multiple models (regressions, mediation and moderation) using polygenic risk score for psychotic experiences (PE-PRS), polygenic risk score for schizophrenia (SCZ-PRS), and polyenvironmental risk score (PERS) in youth from a Brazilian sample. The scores were not able to predict outcome, either when both scores were combined (PERS + PE-PRS and PERS + SCZ-PRS) or separately. Our results show that there is no association between PE and PRS or PERS among adolescents in our Brazilian sample. The lack of association may be a result of the absence of better representativeness regarding genetic and environmental factors of our population.

Identifiants

DOI: 10.1016/j.jpsychires.2021.07.057 PMID: 34450553
pubmed: 34450553
pii: S0022-3956(21)00490-8
doi: 10.1016/j.jpsychires.2021.07.057
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

384-388

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Gabrielle de Oliveira S V Navarro (GOSV)

Laboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil. Electronic address: gabi.onavarro@gmail.com.

Laís Fonseca (L)

Laboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil.

Fernanda Talarico (F)

Department of Psychiatry, University of Alberta, Alberta, Canada.

Letícia Spíndola (L)

Department of Clinical Science, NORMENT, KG Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway; Dr Einar Martens Research Group for Biological Psychiatry, Centre for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.

Marcos L Santoro (ML)

Genetics Division, Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, Brazil.

Vanessa K Ota (VK)

Genetics Division, Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, Brazil.

Hugo Cogo-Moreira (H)

Department of Education, ICT and Learning, Østfold University College, Halden, Norway.

Jair Mari (J)

Laboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil.

Luis A Rohde (LA)

ADHD and Developmental Psychiatry Programs, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil.

Eurípedes C Miguel (EC)

Department of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.

Rodrigo A Bressan (RA)

Laboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil.

Pedro M Pan (PM)

Laboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil.

Ary Gadelha (A)

Laboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil.

Sintia I Belangero (SI)

Laboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil; Genetics Division, Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, Brazil. Electronic address: sinbelangero@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Polyenvironmental and polygenic risk scores...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Polyenvironmental and polygenic risk scores...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Troubles de la perception › Hallucinations › Polyenvironmental and polygenic risk scores...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Polyenvironmental and polygenic risk scores...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité multifactorielle › Polyenvironmental and polygenic risk scores...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Troubles psychotiques › Polyenvironmental and polygenic risk scores...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Polyenvironmental and polygenic risk scores...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Polyenvironmental and polygenic risk scores...