Targeting Adenosine Receptor by Polydeoxyribonucleotide: An Effective Therapeutic Strategy to Induce White-to-Brown Adipose Differentiation and to Curb Obesity.
A2A receptor
Ucp1
adipocytes
browning process
polydeoxyribonucleotide
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
27 Jul 2021
27 Jul 2021
Historique:
received:
03
06
2021
revised:
22
07
2021
accepted:
23
07
2021
entrez:
28
8
2021
pubmed:
29
8
2021
medline:
29
8
2021
Statut:
epublish
Résumé
Obesity is a worldwide chronic metabolic disease characterized by an abnormal fat accumulation and represents one of the main risk factors for several diseases. White adipose tissue is the primary site for energy storage in the form of triglycerides, whereas brown adipose tissue does not store energy-providing lipids but rather dissipates it by producing heat. White-to-brown adipocyte trans-differentiation could represent a new target of anti-obesity strategies and result in fat reduction. Previous studies indicated that adenosine receptor activation induces trans-differentiation of white adipocytes to brown adipocytes. The aim of this study was to evaluate the effects of polydeoxyribonucleotide (PDRN), an A
Identifiants
pubmed: 34451825
pii: ph14080728
doi: 10.3390/ph14080728
pmc: PMC8402160
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Anat. 2009 Jan;214(1):171-8
pubmed: 19018882
J Lipid Res. 2012 Apr;53(4):619-29
pubmed: 22271685
Eur J Pharmacol. 1994 Apr 1;255(1-3):51-5
pubmed: 7517883
Multidiscip Respir Med. 2016 Jul 12;11:28
pubmed: 27408717
J Lipid Res. 2005 Jul;46(7):1369-79
pubmed: 15834118
Biomed Pharmacother. 2021 Jun;138:111538
pubmed: 34311536
Food Chem Toxicol. 2019 Oct;132:110675
pubmed: 31306689
Horm Mol Biol Clin Investig. 2014 Jul;19(1):25-37
pubmed: 25390014
Metab Syndr Relat Disord. 2015 Dec;13(10):423-44
pubmed: 26569333
Cells. 2020 Mar 24;9(3):
pubmed: 32213945
Cardiovasc Hematol Agents Med Chem. 2009 Oct;7(4):313-21
pubmed: 19860658
J Endocrinol. 2002 Dec;175(3):735-44
pubmed: 12475384
Eur J Pharmacol. 2017 Mar 15;799:154-159
pubmed: 28202393
Biomolecules. 2019 Jul 31;9(8):
pubmed: 31370242
J Cell Physiol. 2017 Jan;232(1):61-8
pubmed: 27279601
Cell Metab. 2016 May 10;23(5):770-84
pubmed: 27166942
Int J Mol Sci. 2020 Feb 12;21(4):
pubmed: 32059361
J Biol Chem. 1972 Nov 10;247(21):6866-72
pubmed: 4343159
Front Pharmacol. 2018 May 29;9:506
pubmed: 29896101
Foot Ankle Surg. 2020 Aug;26(6):657-661
pubmed: 31521520
J Allergy Clin Immunol. 2005 May;115(5):911-9; quiz 920
pubmed: 15867843
J Exp Biol. 2018 Mar 7;221(Pt Suppl 1):
pubmed: 29514884
Eur J Nucl Med Mol Imaging. 2019 Mar;46(3):743-750
pubmed: 30105585
Nature. 2000 Apr 6;404(6778):652-60
pubmed: 10766252
Biomedicines. 2020 Oct 20;8(10):
pubmed: 33092298
Int Orthop. 2015 Jul;39(7):1329-34
pubmed: 25920599
Med Sci Monit. 2021 Jan 27;27:e928619
pubmed: 33503016
Trends Neurosci. 2009 Jan;32(1):19-29
pubmed: 19008000
Neuromolecular Med. 2015 Jun;17(2):192-201
pubmed: 25893744
Medicine (Baltimore). 2019 Sep;98(39):e17386
pubmed: 31574892
Obes Rev. 2004 Aug;5(3):145-51
pubmed: 15245383
Nature. 2014 Dec 18;516(7531):395-9
pubmed: 25317558
Front Physiol. 2015 Feb 10;6:36
pubmed: 25713540
Genes Dev. 2013 Feb 1;27(3):234-50
pubmed: 23388824
Front Pharmacol. 2017 Nov 24;8:878
pubmed: 29249968