Free Amino Acid Alterations in Patients with Gynecological and Breast Cancer: A Review.
amino acids
breast cancer
gynecological cancers
metabolomics
proline
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
27 Jul 2021
27 Jul 2021
Historique:
received:
29
06
2021
revised:
15
07
2021
accepted:
21
07
2021
entrez:
28
8
2021
pubmed:
29
8
2021
medline:
29
8
2021
Statut:
epublish
Résumé
Gynecological and breast cancers still remain a significant health problem worldwide. Diagnostic methods are not sensitive and specific enough to detect the disease at an early stage. During carcinogenesis and tumor progression, the cellular need for DNA and protein synthesis increases leading to changes in the levels of amino acids. An important role of amino acids in many biological pathways, including biosynthesis of proteins, nucleic acids, enzymes, etc., which serve as an energy source and maintain redox balance, has been highlighted in many research articles. The aim of this review is a detailed analysis of the literature on metabolomic studies of gynecology and breast cancers with particular emphasis on alterations in free amino acid profiles. The work includes a brief overview of the metabolomic methodology and types of biological samples used in the studies. Special attention was paid to the possible role of selected amino acids in the carcinogenesis, especially proline and amino acids related to its metabolism. There is a clear need for further research and multiple external validation studies to establish the role of amino acid profiling in diagnosing gynecological and breast cancers.
Identifiants
pubmed: 34451829
pii: ph14080731
doi: 10.3390/ph14080731
pmc: PMC8400482
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Bosn J Basic Med Sci. 2020 Feb 05;20(1):78-87
pubmed: 31465717
Metabolites. 2019 Dec 14;9(12):
pubmed: 31847385
J Pharm Biomed Anal. 2014 Jan;87:12-25
pubmed: 23916607
J Biosci Bioeng. 2013 Jul;116(1):9-16
pubmed: 23466298
Cancer Res. 2014 Dec 1;74(23):6867-77
pubmed: 25267063
Sci Rep. 2017 Aug 18;7(1):8803
pubmed: 28821813
J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jul 15;931:97-102
pubmed: 23770739
J Proteome Res. 2013 Jan 4;12(1):505-12
pubmed: 23163809
Mass Spectrom Rev. 2016 Sep;35(5):574-600
pubmed: 25284160
Int J Environ Res Public Health. 2021 Feb 23;18(4):
pubmed: 33672144
Oncotarget. 2016 May 31;7(22):33297-305
pubmed: 27120812
Front Endocrinol (Lausanne). 2018 Mar 12;9:87
pubmed: 29593653
EMBO J. 2017 Aug 15;36(16):2334-2352
pubmed: 28659375
Eur J Cancer Clin Oncol. 1986 Jan;22(1):89-95
pubmed: 3456893
Nat Commun. 2017 May 11;8:15267
pubmed: 28492237
Sci Rep. 2015 Nov 24;5:17206
pubmed: 26598224
Int J Cancer. 2015 Feb 1;136(3):516-26
pubmed: 24895217
Cell Death Differ. 2002 Oct;9(10):1069-77
pubmed: 12232795
J Cancer. 2020 Feb 10;11(9):2540-2551
pubmed: 32201524
PLoS One. 2011;6(9):e24143
pubmed: 21915291
Amino Acids. 2016 Jun;48(6):1339-45
pubmed: 27033065
Rapid Commun Mass Spectrom. 2004;18(21):2558-64
pubmed: 15468143
Folia Histochem Cytobiol. 2007;45 Suppl 1:S181-5
pubmed: 18292830
Metabolism. 2009 Jun;58(6):867-70
pubmed: 19375125
Cancers (Basel). 2020 Nov 19;12(11):
pubmed: 33228226
Sci Rep. 2017 Feb 22;7:43353
pubmed: 28225065
Sci Rep. 2020 Jan 15;10(1):370
pubmed: 31941951
Immunol Cell Biol. 2018 Nov;96(10):1026-1034
pubmed: 29888434
J Biol Chem. 1990 Nov 15;265(32):19600-5
pubmed: 2246245
Curr Opin Clin Nutr Metab Care. 2015 Jan;18(1):71-7
pubmed: 25474014
Clin Cancer Res. 2010 Dec 1;16(23):5835-41
pubmed: 20956617
Science. 1955 Sep 16;122(3168):501-14
pubmed: 13255879
J Proteome Res. 2011 Apr 1;10(4):1765-71
pubmed: 21218854
J Neural Transm Gen Sect. 1990;81(3):225-33
pubmed: 2397086
Cells. 2019 Sep 20;8(10):
pubmed: 31547005
Nat Commun. 2017 Apr 21;8:15074
pubmed: 28429737
Semin Cell Dev Biol. 2005 Feb;16(1):21-7
pubmed: 15659336
Trends Biochem Sci. 2016 Mar;41(3):211-218
pubmed: 26778478
Acta Pol Pharm. 2015 Jul-Aug;72(4):629-41
pubmed: 26647618
Am J Physiol Endocrinol Metab. 2012 Oct 15;303(8):E1036-52
pubmed: 22895781
Anal Chem. 2011 Sep 1;83(17):6689-97
pubmed: 21766834
Cancer Res. 2009 Aug 15;69(16):6414-22
pubmed: 19654292
Oncotarget. 2015 Oct 20;6(32):33369-81
pubmed: 26452258
Biomark Med. 2017 Aug;11(8):619-627
pubmed: 28770610
Onco Targets Ther. 2016 Mar 11;9:1389-98
pubmed: 27042107
Int J Clin Oncol. 2017 Feb;22(1):118-125
pubmed: 27623814
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Clin Chim Acta. 2014 Aug 5;435:42-7
pubmed: 24792383
Transl Oncol. 2016 Aug;9(4):357-70
pubmed: 27567960
Scand J Clin Lab Invest. 2019 Feb - Apr;79(1-2):17-24
pubmed: 30880483
Anal Chem. 2011 Feb 1;83(3):1040-7
pubmed: 21175165
Obstet Gynecol. 2009 Apr;113(4):775-782
pubmed: 19305319
Exp Ther Med. 2012 Jun;3(6):945-951
pubmed: 22969997
Br J Cancer. 2021 Mar;124(5):862-879
pubmed: 33223534
Clin Chim Acta. 2021 Jul;518:59-69
pubmed: 33746017
Mol Cell. 2014 Oct 23;56(2):205-218
pubmed: 25242145
J Plant Physiol. 2008 May 26;165(8):813-24
pubmed: 17920727
Metabolomics. 2019 Oct 29;15(11):146
pubmed: 31664624
Nutr Metab (Lond). 2020 Mar 14;17:20
pubmed: 32190097
Int J Med Sci. 2017 Jan 1;14(1):1-12
pubmed: 28138303
Metabolites. 2021 Feb 10;11(2):
pubmed: 33578791
Nat Commun. 2016 Apr 29;7:11457
pubmed: 27126896
Mol Cell. 2014 Nov 6;56(3):414-424
pubmed: 25458842
Life Sci. 1981 Jan 5;28(1):53-8
pubmed: 6894321
Nutrition. 1999 Mar;15(3):195-9
pubmed: 10198913
PLoS One. 2014 Feb 24;9(2):e89728
pubmed: 24586991
Front Oncol. 2012 Jun 21;2:60
pubmed: 22737668
Clin Cancer Res. 2017 Apr 15;23(8):2081-2092
pubmed: 27797973
Amino Acids. 2021 Apr 5;:
pubmed: 33818628
Br J Cancer. 2018 Jan;118(2):258-265
pubmed: 29169183
J Clin Endocrinol Metab. 2012 Sep;97(9):3216-23
pubmed: 22730518
Cancer Sci. 2018 Apr;109(4):1032-1043
pubmed: 29436067
Plast Reconstr Surg. 2007 Jun;119(7):2023-2028
pubmed: 17519695
Biochem Biophys Res Commun. 2011 Oct 14;414(1):73-8
pubmed: 21945435
Inflamm Res. 1996 Mar;45 Suppl 1:S64-5
pubmed: 8696935
Obstet Gynecol Sci. 2015 Mar;58(2):124-34
pubmed: 25798426
Int J Womens Health. 2016 May 23;8:151-67
pubmed: 27284267
Mol Cell Biol. 2011 Dec;31(24):4938-50
pubmed: 21969607
Lancet Glob Health. 2020 Aug;8(8):e1027-e1037
pubmed: 32710860
Front Bioeng Biotechnol. 2014 Dec 03;2:62
pubmed: 25520953
Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8983-8
pubmed: 22615405
Am J Clin Nutr. 2000 Feb;71(2):583-9
pubmed: 10648275
Cancer Res. 2016 Feb 15;76(4):796-804
pubmed: 26685161
Clin Chim Acta. 2012 May 18;413(9-10):861-8
pubmed: 22309680
Br J Pharmacol. 2010 Oct;161(4):755-67
pubmed: 20636392
Curr Metabolomics. 2013 Jan 1;1(1):83-91
pubmed: 24010053
BMC Cancer. 2018 Oct 12;18(1):973
pubmed: 30314462
Genet Med. 2009 Jan;11(1):3-14
pubmed: 18813139
Talanta. 2016 Apr 1;150:681-9
pubmed: 26838459
J Proteome Res. 2018 Feb 2;17(2):804-812
pubmed: 29235868
Antioxid Redox Signal. 2013 Sep 20;19(9):998-1011
pubmed: 23581681
Metabolites. 2020 Jun 03;10(6):
pubmed: 32503183
Afr Health Sci. 2015 Sep;15(3):982-5
pubmed: 26957990
Cancer Epidemiol Biomarkers Prev. 2010 Sep;19(9):2262-71
pubmed: 20699376
Metabolomics. 2017 Dec 1;14(1):6
pubmed: 30830361
Philos Trans A Math Phys Eng Sci. 2016 Oct 28;374(2079):
pubmed: 27644966
Am J Obstet Gynecol. 2011 Dec;205(6):518-25
pubmed: 21802066
Transplantation. 2007 Jul 15;84(1 Suppl):S17-20
pubmed: 17632406
Life Sci. 2019 Apr 1;222:235-244
pubmed: 30853626
Annu Rev Biochem. 1980;49:1005-61
pubmed: 6250440
Int J Cancer. 2019 Jun 1;144(11):2833-2842
pubmed: 30426507
Mol Oncol. 2015 May;9(5):960-6
pubmed: 25458054
PLoS One. 2019 Jun 10;14(6):e0213419
pubmed: 31181081
J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jan 15;1105:26-37
pubmed: 30562627
BMC Med. 2019 Sep 24;17(1):178
pubmed: 31547832
J Nutr. 2008 Oct;138(10):2008S-2015S
pubmed: 18806116
Carcinogenesis. 2017 May 1;38(5):519-531
pubmed: 28379297
Cancer Cell. 2016 Apr 11;29(4):548-562
pubmed: 27052953
FASEB J. 2009 Feb;23(2):464-72
pubmed: 18845767
J Clin Oncol. 2016 Dec 10;34(35):4225-4230
pubmed: 27903150
J Proteomics. 2013 Dec 6;94:279-88
pubmed: 24125731
Oncotarget. 2016 Jun 28;7(26):39809-39822
pubmed: 27223427
Analyst. 2013 May 7;138(9):2669-77
pubmed: 23486772
Gynecol Oncol. 2016 Jan;140(1):138-44
pubmed: 26521694
Amino Acids. 2021 Jan;53(1):133-138
pubmed: 33179163
Front Oncol. 2020 Jun 30;10:908
pubmed: 32695662
Front Oncol. 2017 Dec 21;7:319
pubmed: 29312889
Chin Med J (Engl). 2020 Nov 4;134(1):28-37
pubmed: 33395072
Science. 1970 Feb 13;167(3920):1003-4
pubmed: 5411169
Front Cell Dev Biol. 2021 Jan 12;8:603837
pubmed: 33511116
Breast Cancer Res. 2018 Dec 4;20(1):148
pubmed: 30514398
Biochemistry. 2018 Jun 26;57(25):3433-3444
pubmed: 29648801
PLoS One. 2018 Feb 13;13(2):e0190958
pubmed: 29438405
Antioxid Redox Signal. 2019 Feb 1;30(4):635-649
pubmed: 28990419
Annu Rev Anim Biosci. 2019 Feb 15;7:263-287
pubmed: 30412672
Cell Death Dis. 2014 Jun 26;5:e1302
pubmed: 24967964
Int J Cancer. 2008 Mar 15;122(6):1435-40
pubmed: 17999410
In Vivo. 2006 Sep-Oct;20(5):587-9
pubmed: 17091764
Int J Clin Oncol. 2014 Apr;19(2):364-72
pubmed: 23700142
Trends Biochem Sci. 2014 Apr;39(4):191-8
pubmed: 24657017
J Nutr. 2007 Jun;137(6 Suppl 2):1681S-1686S
pubmed: 17513447
Cancers (Basel). 2019 Apr 10;11(4):
pubmed: 30974861
Mol Cell. 2011 Dec 23;44(6):864-77
pubmed: 22195962
Metabolomics. 2020 May 25;16(6):68
pubmed: 32451742
J Anal Toxicol. 2015 Oct;39(8):624-8
pubmed: 26378136
Nutrients. 2015 Mar 30;7(4):2176-92
pubmed: 25830943
Transl Oncol. 2013 Dec 01;6(6):757-65
pubmed: 24466379
Analyst. 2014 Mar 7;139(5):1168-77
pubmed: 24443722
Int J Mol Sci. 2017 Dec 16;18(12):
pubmed: 29258187