Tick-Borne Encephalitis Specific Lymphocyte Response after Allogeneic Hematopoietic Stem Cell Transplantation Predicts Humoral Immunity after Vaccination.
allogeneic stem cell transplant
cytokine response
humoral responders
interleukin 13
lymphocyte proliferation
sibling donors
tick-borne encephalitis vaccination
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
15 Aug 2021
15 Aug 2021
Historique:
received:
08
07
2021
revised:
29
07
2021
accepted:
11
08
2021
entrez:
28
8
2021
pubmed:
29
8
2021
medline:
29
8
2021
Statut:
epublish
Résumé
The aim of this prospective study was to assess lymphocyte proliferative and cytokine response prior to and following tick-borne encephalitis (TBE) immunization among patients after allogeneic hematopoietic stem cell transplantation (HSCT). Seventeen adult patients 11-13 months after HSCT and eight unvaccinated healthy adults received up to three TBE vaccinations. Following in vitro stimulation with TBE-antigen, lymphocyte proliferation and cytokine secretion (IL-2, IL-10, IL-13, TNF-alpha, IFN-gamma, GM-CSF) were analyzed by thymidine incorporation assay and the Luminex system. Ten patients (59%) showed significant baseline TBE-specific lymphocyte proliferation (stimulation index (SI) > 3) prior to vaccination, but none of the unvaccinated controls (
Identifiants
pubmed: 34452033
pii: vaccines9080908
doi: 10.3390/vaccines9080908
pmc: PMC8402406
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Austrian Science Fund
ID : grant number KLI 372
Références
Blood. 2003 Feb 1;101(3):831-6
pubmed: 12393732
Transplantation. 2008 Jul 27;86(2):257-63
pubmed: 18645488
Int Immunol. 1993 Jun;5(6):657-63
pubmed: 7688562
Vaccine. 2011 Nov 8;29(48):8769-70
pubmed: 21777636
Br J Haematol. 2001 Dec;115(3):630-41
pubmed: 11736948
Bone Marrow Transplant. 2009 Oct;44(8):457-62
pubmed: 19861978
NPJ Vaccines. 2020 Jul 24;5(1):67
pubmed: 32728481
Biol Blood Marrow Transplant. 2008 Feb;14(2):208-19
pubmed: 18215781
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3730-4
pubmed: 8097323
Biol Blood Marrow Transplant. 2006 Nov;12(11):1176-87
pubmed: 17085311
J Infect Dis. 2017 Mar 15;215(6):896-901
pubmed: 28453842
Vaccines (Basel). 2018 Oct 18;6(4):
pubmed: 30340377
Vaccines (Basel). 2020 Feb 12;8(1):
pubmed: 32059489
Bone Marrow Transplant. 2007 Feb;39(3):179-88
pubmed: 17211432
Blood. 2003 Dec 15;102(13):4600-7
pubmed: 12933579
Blood. 2011 Feb 17;117(7):2265-74
pubmed: 21063025
Bone Marrow Transplant. 2004 Feb;33(3):337-46
pubmed: 14647254
PLoS One. 2015 Oct 14;10(10):e0140545
pubmed: 26465323
Biol Blood Marrow Transplant. 2010 Jan;16(1 Suppl):S133-7
pubmed: 19819340
Bone Marrow Transplant. 2007 Aug;40(3):261-6
pubmed: 17563737
Vaccine. 2021 Feb 12;39(7):1035-1038
pubmed: 33483213
J Immunol. 2006 Feb 1;176(3):1465-73
pubmed: 16424174
Bone Marrow Transplant. 2015 Jul;50(7):899-903
pubmed: 25798674
Eur J Neurol. 2017 Oct;24(10):1214-e61
pubmed: 28762591
Vaccine. 2011 Apr 5;29(16):2825-33
pubmed: 21345379
Prog Clin Biol Res. 1987;244:449-60
pubmed: 2821549