Consideration of Metabolite Efflux in Radiolabelled Choline Kinetics.

choline kinase efflux hypoxia

Journal

Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003

Informations de publication

Date de publication:
12 Aug 2021
Historique:
received: 07 07 2021
revised: 05 08 2021
accepted: 06 08 2021
entrez: 28 8 2021
pubmed: 29 8 2021
medline: 29 8 2021
Statut: epublish

Résumé

Hypoxia is a complex microenvironmental condition known to regulate choline kinase α (CHKA) activity and choline transport through transcription factor hypoxia-inducible factor-1α (HIF-1α) and, therefore, may confound the uptake of choline radiotracer [

Identifiants

pubmed: 34452207
pii: pharmaceutics13081246
doi: 10.3390/pharmaceutics13081246
pmc: PMC8400349
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Medical Research Council grant
ID : MR/N020782/1
Organisme : Medical Research Council
ID : MR/N020782/1
Pays : United Kingdom
Organisme : Imperial College NIHR Biomedical Research Centre
ID : WSCC_P62585
Organisme : Imperial College Experimental Cancer Medicines award
ID : C1312/A25149
Organisme : Cancer Research UK
ID : C2536/A10337
Pays : United Kingdom

Références

Braz J Med Biol Res. 2017 Dec 11;51(2):e6373
pubmed: 29267497
Biochim Biophys Acta. 2005 Mar 21;1733(1):53-66
pubmed: 15749057
Nucl Med Biol. 2011 Jan;38(1):39-51
pubmed: 21220128
Cancer Res. 1999 Jan 1;59(1):80-4
pubmed: 9892190
J Cereb Blood Flow Metab. 1985 Dec;5(4):584-90
pubmed: 4055928
Cancer Res. 2004 Jun 15;64(12):4270-6
pubmed: 15205341
Ophthalmic Physiol Opt. 2014 Sep;34(5):502-8
pubmed: 24697967
J Pharmacol Exp Ther. 2015 Sep;354(3):384-93
pubmed: 26148857
PLoS One. 2009 Nov 12;4(11):e7819
pubmed: 19915674
Cancer Res. 2005 Aug 1;65(15):6943-9
pubmed: 16061679
Cancer Res. 2008 Jan 1;68(1):172-80
pubmed: 18172309
Cell. 1994 Jul 1;77(7):1071-81
pubmed: 7912658
Nucl Med Biol. 2006 Nov;33(8):977-84
pubmed: 17127170
Cancer Res. 2006 May 1;66(9):4802-7
pubmed: 16651435
Am J Physiol Endocrinol Metab. 2001 Sep;281(3):E524-36
pubmed: 11500308
J Nucl Med. 1996 Dec;37(12):2049-57
pubmed: 8970533
Hepatology. 2014 Aug;60(2):610-21
pubmed: 24723470
Theranostics. 2020 Jul 9;10(19):8677-8690
pubmed: 32754271
BMC Biol. 2013 Jun 17;11:69
pubmed: 23773777
World J Gastroenterol. 2018 Aug 7;24(29):3222-3238
pubmed: 30090003
Biochem J. 2006 Feb 15;394(Pt 1):325-34
pubmed: 16236026
Nat Rev Drug Discov. 2006 Mar;5(3):219-34
pubmed: 16518375
Toxicol Appl Pharmacol. 2016 Nov 1;310:215-228
pubmed: 27664577
Cancer Res. 2019 Apr 1;79(7):1696-1704
pubmed: 30760520
Essays Biochem. 2011 Sep 7;50(1):209-32
pubmed: 21967059
Adv Exp Med Biol. 2008;614:157-64
pubmed: 18290326
Mol Cancer Ther. 2016 Feb;15(2):323-33
pubmed: 26769123
J Cereb Blood Flow Metab. 2020 Sep;40(9):1769-1777
pubmed: 32663096
Clin Cancer Res. 2011 Dec 15;17(24):7673-83
pubmed: 22038995
BMC Cancer. 2008 Feb 13;8:51
pubmed: 18271955
Cancer Res. 2001 Jan 1;61(1):110-7
pubmed: 11196147
J Lipid Res. 2012 Jan;53(1):149-57
pubmed: 22025560
Cancer Res. 2001 May 1;61(9):3599-603
pubmed: 11325827
Br J Cancer. 2010 May 25;102(11):1555-77
pubmed: 20502460
FASEB J. 2003 Mar;17(3):503-5
pubmed: 12514119
Acta Biochim Biophys Sin (Shanghai). 2007 Sep;39(9):668-74
pubmed: 17805461
Lancet Oncol. 2007 Oct;8(10):889-97
pubmed: 17851129
Oncogene. 2012 Mar 15;31(11):1431-41
pubmed: 21822308
J Nucl Med. 2020 Jun;61(6):827-833
pubmed: 31862801
Nutrients. 2018 Oct 16;10(10):
pubmed: 30332744
Front Physiol. 2014 Jan 08;4:400
pubmed: 24409151
Cancer Sci. 2018 Apr;109(4):944-955
pubmed: 29383798
Circ Res. 2008 May 9;102(9):1075-81
pubmed: 18356544
Cancer Res. 2009 Oct 1;69(19):7721-8
pubmed: 19773436
Oncotarget. 2016 Jun 14;7(24):37103-37120
pubmed: 27206796
Clin Cancer Res. 2009 Sep 1;15(17):5503-10
pubmed: 19706823
Annu Rev Pharmacol Toxicol. 2007;47:731-59
pubmed: 17002597
Clin Cancer Res. 2012 Feb 15;18(4):1063-72
pubmed: 22235095
Medchemcomm. 2013 Apr 1;2013(4):693-696
pubmed: 24976941

Auteurs

Yunqing Li (Y)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

Marianna Inglese (M)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

Suraiya Dubash (S)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

Chris Barnes (C)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

Diana Brickute (D)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

Marta Costa Braga (MC)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

Ning Wang (N)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

Alice Beckley (A)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

Kathrin Heinzmann (K)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

Louis Allott (L)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

Haonan Lu (H)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

Cen Chen (C)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

Ruisi Fu (R)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

Laurence Carroll (L)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.
Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Eric O Aboagye (EO)

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

Classifications MeSH