Cytomegalovirus Serostatus and Functional Impairment in Liver Transplant Recipients in the Current Era.
Adult
Aged
Cohort Studies
Cytomegalovirus
/ immunology
Cytomegalovirus Infections
/ complications
Female
Functional Status
Humans
Liver Transplantation
/ adverse effects
Male
Middle Aged
Propensity Score
Seroepidemiologic Studies
Tissue Donors
/ statistics & numerical data
Transplant Recipients
/ statistics & numerical data
cytomegalovirus
functional status
outcomes
transplant
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
01 08 2021
01 08 2021
Historique:
received:
08
07
2021
accepted:
29
07
2021
entrez:
28
8
2021
pubmed:
29
8
2021
medline:
3
2
2022
Statut:
epublish
Résumé
Whether donor (D+) or recipient (R+) cytomegalovirus (CMV) seropositivity is associated with functional impairment in liver transplant recipients is not known. Patients included adult liver transplant recipients in the Organ Procurement and Transplantation Network database transplanted over a five-year period from 1 January 2014-31 December 2018. Functional status in the database was assessed using Karnofsky performance scale. A logistic regression model that controlled for potential confounders was used to examine the association of CMV serostatus and functional status. Variables significantly associated with functional status ( Among 30,267 adult liver transplant recipients, D+ or R+ patients had significantly lower functional status at last follow-up than the D-R- cohort (OR 0.88, 95% CI 0.80-0.96, D+ or R+ liver transplant recipients had lower functional status and higher risk of deaths due to infections. Future studies are warranted to examine the mechanistic basis of these findings in the setting of transplantation.
Sections du résumé
BACKGROUND
Whether donor (D+) or recipient (R+) cytomegalovirus (CMV) seropositivity is associated with functional impairment in liver transplant recipients is not known.
METHODS
Patients included adult liver transplant recipients in the Organ Procurement and Transplantation Network database transplanted over a five-year period from 1 January 2014-31 December 2018. Functional status in the database was assessed using Karnofsky performance scale. A logistic regression model that controlled for potential confounders was used to examine the association of CMV serostatus and functional status. Variables significantly associated with functional status (
RESULTS
Among 30,267 adult liver transplant recipients, D+ or R+ patients had significantly lower functional status at last follow-up than the D-R- cohort (OR 0.88, 95% CI 0.80-0.96,
CONCLUSIONS
D+ or R+ liver transplant recipients had lower functional status and higher risk of deaths due to infections. Future studies are warranted to examine the mechanistic basis of these findings in the setting of transplantation.
Identifiants
pubmed: 34452384
pii: v13081519
doi: 10.3390/v13081519
pmc: PMC8402920
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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