The Anterior GRadient (AGR) family proteins in epithelial ovarian cancer.
AGR2
AGR3
Endoplasmic reticulum proteins
Epithelial ovarian Cancer
Journal
Journal of experimental & clinical cancer research : CR
ISSN: 1756-9966
Titre abrégé: J Exp Clin Cancer Res
Pays: England
ID NLM: 8308647
Informations de publication
Date de publication:
27 Aug 2021
27 Aug 2021
Historique:
received:
26
03
2021
accepted:
04
08
2021
entrez:
28
8
2021
pubmed:
29
8
2021
medline:
6
1
2022
Statut:
epublish
Résumé
Epithelial ovarian cancer (EOC) is the most common gynecologic disorder. Even with the recent progresses made towards the use of new therapeutics, it still represents the most lethal gynecologic malignancy in women from developed countries.The discovery of the anterior gradient proteins AGR2 and AGR3, which are highly related members belonging to the protein disulfide isomerase (PDI) family, attracted researchers' attention due to their putative involvement in adenocarcinoma development. This review compiles the current knowledge on the role of the AGR family and the expression of its members in EOC and discusses the potential clinical relevance of AGR2 and AGR3 for EOC diagnosis, prognosis, and therapeutics.A better understanding of the role of the AGR family may thus provide new handling avenues for EOC patients.
Identifiants
pubmed: 34452625
doi: 10.1186/s13046-021-02060-z
pii: 10.1186/s13046-021-02060-z
pmc: PMC8394676
doi:
Substances chimiques
Biomarkers, Tumor
0
Neoplasm Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
271Informations de copyright
© 2021. The Author(s).
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