Protease cleavage of RNF20 facilitates coronavirus replication via stabilization of SREBP1.

Animals Antiviral Agents / pharmacology Cell Line Chlorocebus aethiops Coronavirus 3C Proteases / metabolism Gene Expression Regulation Interferons / physiology Protein Stability SARS-CoV-2 / immunology Sterol Regulatory Element Binding Protein 1 / antagonists & inhibitors Ubiquitin-Protein Ligases / metabolism Vero Cells Virus Replication
RNF20 RNF40 SARS-CoV-2 SREBP1 protease

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
14 09 2021
Historique:
entrez: 28 8 2021
pubmed: 29 8 2021
medline: 15 9 2021
Statut: ppublish

Résumé

COVID-19, caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), has presented a serious risk to global public health. The viral main protease M

Identifiants

DOI: 10.1073/pnas.2107108118 PMID: 34452991 PMC: PMC8449311
pubmed: 34452991
pii: 2107108118
doi: 10.1073/pnas.2107108118
pmc: PMC8449311
pii:
doi:

Substances chimiques

Antiviral Agents 0
SREBF1 protein, human 0
Sterol Regulatory Element Binding Protein 1 0
Interferons 9008-11-1
RNF20 protein, human EC 2.3.2.27
RNF40 protein, human EC 2.3.2.27
Ubiquitin-Protein Ligases EC 2.3.2.27
3C-like proteinase, SARS-CoV-2 EC 3.4.22.-
Coronavirus 3C Proteases EC 3.4.22.28

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : AI069120
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI158154
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI069120
Pays : United States
Organisme : NIH HHS
ID : AI149718
Pays : United States
Organisme : NIH HHS
ID : AI158154
Pays : United States

Informations de copyright

Copyright © 2021 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no competing interest.

Références

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Auteurs

Shilei Zhang (S)

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
ORCID: 0000-0002-1171-9470

Jingfeng Wang (J)

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Suzhou Institute of System Medicine, Suzhou 215123, China.
ORCID: 0000-0002-5170-3887

Genhong Cheng (G)

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095; gcheng@mednet.ucla.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Protease cleavage of RNF20 facilitates...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Protease cleavage of RNF20 facilitates...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Protease cleavage of RNF20 facilitates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Protease cleavage of RNF20 facilitates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales non structurales › Protéases virales › Protéases virales 3C › Protéases 3C des coronavirus › Protease cleavage of RNF20 facilitates...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Protease cleavage of RNF20 facilitates...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Protease cleavage of RNF20 facilitates...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Stabilité protéique › Protease cleavage of RNF20 facilitates...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Protease cleavage of RNF20 facilitates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines › Protéines de liaison à l'élément de régulation des stérols › Protéine-1 de liaison à l'élément de régulation des stérols › Protease cleavage of RNF20 facilitates...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › Protease cleavage of RNF20 facilitates...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Vero › Protease cleavage of RNF20 facilitates...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Protease cleavage of RNF20 facilitates...