An Overview of Adult Neurogenesis.
Cellular proliferation
Neural stem cells
Neurogenesis
Neuronal differentiation
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
28
8
2021
pubmed:
29
8
2021
medline:
1
9
2021
Statut:
ppublish
Résumé
Neurogenesis is maintained in the mammalian brain throughout adulthood in two main regions: the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the hippocampal dentate gyrus. Adult neurogenesis is a process composed of multiple steps by which neurons are generated from dividing adult neural stem cells and migrate to be integrated into existing neuronal circuits. Alterations in any of these steps impair neurogenesis and may compromise brain function, leading to cognitive impairment and neurodegenerative diseases. Therefore, understanding the cellular and molecular mechanisms that modulate adult neurogenesis is the centre of attention of regenerative research. In this chapter, we review the main properties of the adult neurogenic niches.
Identifiants
pubmed: 34453294
doi: 10.1007/978-3-030-74046-7_7
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
77-94Informations de copyright
© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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