Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network.

antioxidant galactose hormesis oxidative stress pentose phosphate pathway

Journal

Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818

Informations de publication

Date de publication:
11 2021
Historique:
revised: 24 07 2021
received: 27 04 2021
pubmed: 29 8 2021
medline: 1 4 2022
entrez: 28 8 2021
Statut: ppublish

Résumé

Galactose, a ubiquitous monosaccharide with incompletely understood physiology is often exploited for inducing oxidative-stress mediated aging in animals. Recent research demonstrates that galactose can conserve cellular function during periods of starvation and prevent/alleviate cognitive deficits in a rat model of sporadic Alzheimer's disease. The present aim is to examine the acute effects of oral galactose on the redox regulatory network (RRN). Rat plasma and hippocampal RRNs are analyzed upon acute orogastric gavage of galactose (200 mg kg Based on the observed findings, and in the context of previous work on galactose, a hormetic hypothesis of galactose is proposed suggesting that the protective effects may be inseparable from its pro-oxidative action at the biochemical level.

Identifiants

pubmed: 34453395
doi: 10.1002/mnfr.202100400
doi:

Substances chimiques

Sugars 0
Galactose X2RN3Q8DNE

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2100400

Informations de copyright

© 2021 Wiley-VCH GmbH.

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Auteurs

Jan Homolak (J)

Department of Pharmacology, University of Zagreb School of Medicine, Zagreb, Croatia.
Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia.

Ana Babic Perhoc (A)

Department of Pharmacology, University of Zagreb School of Medicine, Zagreb, Croatia.
Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia.

Ana Knezovic (A)

Department of Pharmacology, University of Zagreb School of Medicine, Zagreb, Croatia.
Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia.

Ivan Kodvanj (I)

Department of Pharmacology, University of Zagreb School of Medicine, Zagreb, Croatia.
Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia.

Davor Virag (D)

Department of Pharmacology, University of Zagreb School of Medicine, Zagreb, Croatia.
Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia.

Jelena Osmanovic Barilar (J)

Department of Pharmacology, University of Zagreb School of Medicine, Zagreb, Croatia.
Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia.

Peter Riederer (P)

Clinic and Polyclinic for Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany.
University of Southern Denmark Odense, Odense, Denmark.

Melita Salkovic-Petrisic (M)

Department of Pharmacology, University of Zagreb School of Medicine, Zagreb, Croatia.
Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia.

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