Parietal epithelial cell dysfunction in crescentic glomerulonephritis.
Crescentic glomerulonephritis
Immune system
Parietal cell activation
Parietal epithelial cells
Podocyte gain
Journal
Cell and tissue research
ISSN: 1432-0878
Titre abrégé: Cell Tissue Res
Pays: Germany
ID NLM: 0417625
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
16
02
2021
accepted:
15
07
2021
pubmed:
29
8
2021
medline:
19
2
2022
entrez:
28
8
2021
Statut:
ppublish
Résumé
Crescentic glomerulonephritis represents a group of kidney diseases characterized by rapid loss of kidney function and the formation of glomerular crescents. While the role of the immune system has been extensively studied in relation to the development of crescents, recent findings show that parietal epithelial cells play a key role in the pathophysiology of crescent formation, even in the absence of immune modulation. This review highlights our current understanding of parietal epithelial cell biology and the reported physiological and pathological roles that these cells play in glomerular lesion formation, especially in the context of crescentic glomerulonephritis.
Identifiants
pubmed: 34453566
doi: 10.1007/s00441-021-03513-9
pii: 10.1007/s00441-021-03513-9
pmc: PMC8523405
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
345-354Informations de copyright
© 2021. The Author(s).
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