Assessment of novel surgical procedures using decellularised muscle and bioactive ceramic: a histological analysis.
Animals
Biocompatible Materials
/ chemistry
Bone Regeneration
/ drug effects
Bone Substitutes
/ chemistry
Calcium Phosphates
/ chemistry
Cells, Cultured
Ceramics
/ chemistry
Decellularized Extracellular Matrix
/ chemistry
Humans
Mesenchymal Stem Cells
/ drug effects
Mice
Mice, Nude
Mice, Transgenic
Muscles
/ chemistry
Osteogenesis
/ drug effects
Prosthesis Implantation
/ instrumentation
Skull
/ drug effects
Tissue Engineering
/ methods
Journal
Journal of materials science. Materials in medicine
ISSN: 1573-4838
Titre abrégé: J Mater Sci Mater Med
Pays: United States
ID NLM: 9013087
Informations de publication
Date de publication:
28 Aug 2021
28 Aug 2021
Historique:
received:
11
11
2020
accepted:
21
06
2021
entrez:
28
8
2021
pubmed:
29
8
2021
medline:
28
1
2022
Statut:
epublish
Résumé
Tissue regeneration and neovascularisation in cases of major bone loss is a challenge in maxillofacial surgery. The hypothesis of the present study is that the addition of resorbable bioactive ceramic Silica Calcium Phosphate Cement (SCPC) to Declluraized Muscle Scaffold (DSM) can expedite bone formation and maturation. Two surgical defect models were created in 18 nude transgenic mice. Group 1(n = 6), with a 2-mm decortication calvarial defect, was treated with a DSM/SCPC sheet over the corticated bone as an onlay then seeded with human Mesenchymal Stromal Cells hMSC in situ. In Group 2 (n = 6), a critical size (4 mm) calvarial defect was made and grafted with DSM/SCPC/in situ human bone marrow stromal cells (hMSCs). The control groups included Group 3 (n = 3) animals, with a 2-mm decortication defect treated with an onlay DSM sheet, and Group 4 (n = 3) animals, treated with critical size defect grafted with plain DSM. After 8 weeks, bone regeneration in various groups was evaluated using histology, immunohistochemistry and histomorphometry. New bone formation and maturation was superior in groups treated with DSM/SCPC/hMSC. The DMS/SCPC scaffold has the ability to augment and induce bone regeneration and neovascularisation in cases of major bone resorption and critical size defects.
Identifiants
pubmed: 34453610
doi: 10.1007/s10856-021-06585-9
pii: 10.1007/s10856-021-06585-9
pmc: PMC8403111
doi:
Substances chimiques
Biocompatible Materials
0
Bone Substitutes
0
Calcium Phosphates
0
Decellularized Extracellular Matrix
0
calcium phosphate
97Z1WI3NDX
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113Subventions
Organisme : Deanship of Scientific Research, King Saud University
ID : RG-1439-062
Informations de copyright
© 2021. The Author(s).
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