The C-terminal domain of the heavy chain of tetanus toxin prevents the oxidative and nitrosative stress induced by acute toxicity of 1-methyl-4-phenylpyridinium, a rat model of Parkinson's disease.

1-Methyl-4-phenylpyridinium / toxicity Animals Nitrosative Stress Oxidative Stress Parkinson Disease / drug therapy Peptide Fragments / metabolism Rats Tetanus Toxin / metabolism
1-Methyl-4-phenylpyridinium Carboxyl-terminal domain of the heavy chain of tetanus toxin Oxidative stress Parkinson’s disease Superoxide dismutase

Journal

Neuroscience research
ISSN: 1872-8111
Titre abrégé: Neurosci Res
Pays: Ireland
ID NLM: 8500749

Informations de publication

Date de publication:
Jan 2022
Historique:
received: 18 05 2021
revised: 11 08 2021
accepted: 22 08 2021
pubmed: 29 8 2021
medline: 11 1 2022
entrez: 28 8 2021
Statut: ppublish

Résumé

The recombinant carboxyl-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) exerts neuroprotective and neurorestorative effects on the dopaminergic system of animal models of Parkinson's disease (PD). The present study aimed to determine the effect of the Hc-TeTx fragment on the markers of oxidative stress and nitrosative stress generated by the acute toxicity of 1-methyl-4-phenylpyridinium (MPP

Identifiants

DOI: 10.1016/j.neures.2021.08.005 PMID: 34453989
pubmed: 34453989
pii: S0168-0102(21)00190-5
doi: 10.1016/j.neures.2021.08.005
pii:
doi:

Substances chimiques

Peptide Fragments 0
Tetanus Toxin 0
1-Methyl-4-phenylpyridinium R865A5OY8J

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

36-45

Informations de copyright

Copyright © 2021 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.

Auteurs

Felipe Patricio (F)

Laboratorio de Neurofarmacología, Facultad de Ciencias Químicas - Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.

Daniel Juárez-Torres (D)

Laboratorio de Neurofarmacología, Facultad de Ciencias Químicas - Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.

Aleidy Patricio-Martínez (A)

Laboratorio de Neurofarmacología, Facultad de Ciencias Químicas - Benemérita Universidad Autónoma de Puebla, Puebla, Mexico; Facultad de Ciencias Biológicas - Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.

Liliana Mendieta (L)

Laboratorio de Neuroquímica, Facultad de Ciencias Químicas - Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.

Francisca Pérez-Severiano (F)

Laboratorio de Neurofarmacología Molecular y Nanotecnología, Instituto Nacional de Neurología y Neurocirugía - Manuel Velasco Suárez, 14269 Mexico City, Mexico.

Sergio Montes (S)

Departamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía - Manuel Velasco Suárez, 14269 Mexico City, Mexico.

José Aguilera (J)

Institut de Neurociències and Departament de Bioquímica i de Biologia Molecular, Facultat de Medicina, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

Ilhuicamina Daniel Limón (ID)

Laboratorio de Neurofarmacología, Facultad de Ciencias Químicas - Benemérita Universidad Autónoma de Puebla, Puebla, Mexico. Electronic address: ilhlimon@yahoo.com.mx.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Composés de pyridinium › 1-Méthyl-4-phényl-pyridinium › The C-terminal domain of the heavy chain of...
questionsmedicales.fr › Eucaryotes › Animaux › The C-terminal domain of the heavy chain of...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Stress nitrosatif › The C-terminal domain of the heavy chain of...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › The C-terminal domain of the heavy chain of...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › The C-terminal domain of the heavy chain of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Fragments peptidiques › The C-terminal domain of the heavy chain of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › The C-terminal domain of the heavy chain of...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Toxine tétanique › The C-terminal domain of the heavy chain of...