Reinforcing the evidence of oligoclonal bands as a prognostic factor in patients with Multiple sclerosis.
Multiple sclerosis
Multiple sclerosis severity score
Oligoclonal bands
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
30
07
2021
revised:
09
08
2021
accepted:
15
08
2021
pubmed:
30
8
2021
medline:
17
12
2021
entrez:
29
8
2021
Statut:
ppublish
Résumé
The prognostic value of oligoclonal bands in the cerebrospinal fluid of Multiple Sclerosis (MS) patients is controversial. While several studies have demonstrated a worse disease course in OCB positive patients, others did not reproduce these findings. We evaluated the prognostic significance of OCB retrospectively based on clinical records of OCB status upon diagnosis and severity outcomes including the MS Severity Score, Progression Index and regional involvement in Magnetic Resonance Imaging. OCB positive patients had a higher median MSSS and PI, and a greater proportion of spinal cord involvement. These findings provide further evidence of the prognostic importance of OCB in MS patients.
Identifiants
pubmed: 34455137
pii: S2211-0348(21)00487-9
doi: 10.1016/j.msard.2021.103220
pii:
doi:
Substances chimiques
Oligoclonal Bands
0
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
103220Informations de copyright
Copyright © 2021. Published by Elsevier B.V.