GSK2256294 Decreases sEH (Soluble Epoxide Hydrolase) Activity in Plasma, Muscle, and Adipose and Reduces F2-Isoprostanes but Does Not Alter Insulin Sensitivity in Humans.


Journal

Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255

Informations de publication

Date de publication:
09 2021
Historique:
pubmed: 31 8 2021
medline: 14 1 2022
entrez: 30 8 2021
Statut: ppublish

Résumé

[Figure: see text].

Identifiants

pubmed: 34455816
doi: 10.1161/HYPERTENSIONAHA.121.17659
pmc: PMC8429121
mid: NIHMS1728867
doi:

Substances chimiques

Cyclohexylamines 0
F2-Isoprostanes 0
N-((4-cyano-2-(trifluoromethyl)phenyl)methyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexanecarboxamide 0
Triazines 0
Epoxide Hydrolases EC 3.3.2.-

Types de publication

Journal Article Randomized Controlled Trial Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1092-1102

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002245
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007569
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117875
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020593
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024975
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK114809
Pays : United States

Références

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Auteurs

James M Luther (JM)

Department of Medicine, Division of Clinical Pharmacology (J.M.L., D.W., A.D., R.M., D.P., J.G., N.J.B.), Vanderbilt University Medical Center.

Justina Ray (J)

Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (J.R.).

Dawei Wei (D)

Department of Medicine, Division of Clinical Pharmacology (J.M.L., D.W., A.D., R.M., D.P., J.G., N.J.B.), Vanderbilt University Medical Center.

John R Koethe (JR)

Department of Medicine, Division of Infectious Diseases (J.R.K., L.H.), Vanderbilt University Medical Center.

Latoya Hannah (L)

Department of Medicine, Division of Infectious Diseases (J.R.K., L.H.), Vanderbilt University Medical Center.

Anthony DeMatteo (A)

Department of Medicine, Division of Clinical Pharmacology (J.M.L., D.W., A.D., R.M., D.P., J.G., N.J.B.), Vanderbilt University Medical Center.

Robert Manning (R)

Department of Medicine, Division of Clinical Pharmacology (J.M.L., D.W., A.D., R.M., D.P., J.G., N.J.B.), Vanderbilt University Medical Center.

Andrew S Terker (AS)

Department of Medicine, Division of Nephrology and Hypertension (A.S.T.), Vanderbilt University Medical Center.

Dungeng Peng (D)

Department of Medicine, Division of Clinical Pharmacology (J.M.L., D.W., A.D., R.M., D.P., J.G., N.J.B.), Vanderbilt University Medical Center.

Hui Nian (H)

Department of Biostatistics (H.N., C.Y.), Vanderbilt University Medical Center.

Chang Yu (C)

Department of Biostatistics (H.N., C.Y.), Vanderbilt University Medical Center.

Mona Mashayekhi (M)

Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism (M.M.), Vanderbilt University Medical Center.

Jorge Gamboa (J)

Department of Medicine, Division of Clinical Pharmacology (J.M.L., D.W., A.D., R.M., D.P., J.G., N.J.B.), Vanderbilt University Medical Center.

Nancy J Brown (NJ)

Department of Medicine, Division of Clinical Pharmacology (J.M.L., D.W., A.D., R.M., D.P., J.G., N.J.B.), Vanderbilt University Medical Center.
Yale School of Medicine (N.J.B.).

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