Biology of HPV Mediated Carcinogenesis and Tumor Progression.
Journal
Seminars in radiation oncology
ISSN: 1532-9461
Titre abrégé: Semin Radiat Oncol
Pays: United States
ID NLM: 9202882
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
entrez:
30
8
2021
pubmed:
31
8
2021
medline:
26
4
2022
Statut:
ppublish
Résumé
Human papillomavirus (HPV) is a ubiquitous DNA virus that infects squamous epithelia. Though HPV only encodes 8 genes, it is capable of causing cellular transformation and ultimately cancer in host cells. In this article we review the classification of HPV viruses, their genetic structure and life cycle, viral gene biology, and provide an overview of the role of HPV in cancer. We explain how the viral life cycle can lead to integration of viral DNA into the host genome leading to increased cell cycle progression, decreased apoptosis, altered DNA repair, and chromosomal instability. We describe the multifaceted roles of the canonical oncogenes E6 and E7 in promoting tumorigenesis and the important role of other viral genes in regulating cancer development. We also review how the virus actively suppresses innate and adaptive immunity to evade immune detection and promote a pro-tumorigenic microenvironment. The biology presented here will serve as a foundation to the other chapters in this edition and we hope it will incite enthusiasm for continued research on this fascinating virus that causes significant morbidity and mortality worldwide.
Identifiants
pubmed: 34455982
pii: S1053-4296(21)00014-X
doi: 10.1016/j.semradonc.2021.02.006
pmc: PMC8409095
mid: NIHMS1683070
pii:
doi:
Substances chimiques
Oncogene Proteins, Viral
0
Papillomavirus E7 Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
265-273Subventions
Organisme : NCI NIH HHS
ID : P30 CA014520
Pays : United States
Organisme : NIDCR NIH HHS
ID : P50 DE026787
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Références
J Virol. 1991 May;65(5):2254-60
pubmed: 1850010
Nat Immunol. 2016 Sep 20;17(10):1142-9
pubmed: 27648547
Nat Genet. 2015 Feb;47(2):158-63
pubmed: 25581428
J Virol. 2010 Jan;84(1):543-57
pubmed: 19846509
EMBO J. 1999 Sep 15;18(18):5061-72
pubmed: 10487758
Oncotarget. 2017 Dec 14;9(5):6015-6027
pubmed: 29464051
Cancer Res. 2004 Feb 15;64(4):1359-68
pubmed: 14973079
J Virol. 2013 Jun;87(11):6062-72
pubmed: 23536685
J Clin Invest. 2020 Apr 1;130(4):1635-1652
pubmed: 31874109
J Virol. 1994 Jul;68(7):4262-73
pubmed: 8207801
Virology. 2011 Jun 5;414(2):153-63
pubmed: 21492895
J Virol. 1996 Jul;70(7):4509-16
pubmed: 8676476
Int J Gynecol Cancer. 1995 Sep;5(5):366-373
pubmed: 11578506
Cancer Immunol Immunother. 2009 Jan;58(1):39-47
pubmed: 18438663
Genes Dev. 1998 Jul 1;12(13):2061-72
pubmed: 9649509
Int J Cancer. 2013 Feb 15;132(4):882-90
pubmed: 22821242
Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16175-80
pubmed: 24046371
Clin Exp Immunol. 1999 Apr;116(1):33-40
pubmed: 10209502
Mutat Res Rev Mutat Res. 2017 Apr - Jun;772:3-12
pubmed: 28528688
Int J Cancer. 2016 Jan 1;138(1):171-81
pubmed: 26178914
Virus Res. 2002 Nov;89(2):213-28
pubmed: 12445661
J Clin Oncol. 2006 Feb 10;24(5):736-47
pubmed: 16401683
Papillomavirus Res. 2019 Jun;7:176-179
pubmed: 30974183
PLoS One. 2015 Jul 01;10(7):e0131675
pubmed: 26132923
EMBO J. 1987 Nov;6(11):3391-7
pubmed: 2828029
Oncogene. 2001 Nov 26;20(54):7874-87
pubmed: 11753670
Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10002-7
pubmed: 10944189
Int J Oncol. 2018 Aug;53(2):579-591
pubmed: 29901186
Int J Cancer. 2020 Apr 1;146(7):2047-2058
pubmed: 31732968
J Virol. 2003 Apr;77(8):4818-26
pubmed: 12663788
Mutat Res Rev Mutat Res. 2017 Apr - Jun;772:13-22
pubmed: 28528686
J Virol. 2002 Sep;76(17):8710-21
pubmed: 12163591
Oncogene. 2003 Feb 27;22(8):1225-37
pubmed: 12606949
Cell. 2015 Jan 15;160(1-2):48-61
pubmed: 25594174
Virus Res. 2017 Mar 2;231:21-33
pubmed: 27890631
EMBO J. 1989 Dec 20;8(13):4099-105
pubmed: 2556261
PLoS Pathog. 2009 Feb;5(2):e1000318
pubmed: 19247434
Front Oncol. 2019 May 08;9:355
pubmed: 31134154
Nature. 2017 Mar 16;543(7645):378-384
pubmed: 28112728
Cancer Res. 2002 Dec 1;62(23):7075-82
pubmed: 12460929
J Virol. 1999 Aug;73(8):6209-19
pubmed: 10400710
Lancet. 2007 Sep 8;370(9590):890-907
pubmed: 17826171
J Clin Pathol. 2006 May;59(5):513-7
pubmed: 16484445
Virology. 1993 Oct;196(2):855-60
pubmed: 8396813
Proc Natl Acad Sci U S A. 2016 May 31;113(22):6289-94
pubmed: 27190090
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4350-4
pubmed: 8633069
Cancer Res. 2009 Sep 1;69(17):7022-9
pubmed: 19706760
J Virol. 2011 Nov;85(21):11372-80
pubmed: 21849431
Front Biosci. 2006 Sep 01;11:2286-302
pubmed: 16720315
Semin Cancer Biol. 2003 Feb;13(1):59-67
pubmed: 12507557
Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19552-19562
pubmed: 31501315
Oncotarget. 2015 Sep 29;6(29):26995-7007
pubmed: 26336991
Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6289-93
pubmed: 7603984
J Virol. 1989 Oct;63(10):4417-21
pubmed: 2476573
Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18780-5
pubmed: 19843693
N Engl J Med. 2010 Jul 1;363(1):24-35
pubmed: 20530316
Viruses. 2017 Aug 18;9(8):
pubmed: 28820495
Oncogene. 1996 Dec 5;13(11):2323-30
pubmed: 8957073
Virus Res. 2017 Mar 2;231:50-55
pubmed: 27863966
J Biol Chem. 2000 Mar 10;275(10):6764-9
pubmed: 10702232
Gynecol Oncol. 2004 Mar;92(3):873-80
pubmed: 14984955
Cancer Res. 2007 Jan 1;67(1):354-61
pubmed: 17210718
Immunity. 2006 Feb;24(2):191-201
pubmed: 16473831
Virology. 2013 Oct;445(1-2):35-56
pubmed: 24029589
Cancer Res. 2020 Feb 15;80(4):732-746
pubmed: 31848196
Genome Res. 2014 Feb;24(2):185-99
pubmed: 24201445
Clin Microbiol Rev. 2012 Apr;25(2):215-22
pubmed: 22491770
J Virol. 2002 Nov;76(22):11291-300
pubmed: 12388689
Virology. 1994 Jan;198(1):169-74
pubmed: 8259651
Science. 2013 Feb 15;339(6121):786-91
pubmed: 23258413
PLoS One. 2015 Mar 20;10(3):e0119566
pubmed: 25793388
Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21573-21579
pubmed: 31591214
Cancers (Basel). 2019 Nov 22;11(12):
pubmed: 31766658
Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1654-8
pubmed: 7878034
Genes Dev. 1997 Aug 15;11(16):2101-11
pubmed: 9284049
J Virol. 2011 Sep;85(18):9486-94
pubmed: 21734056
Science. 2015 Oct 30;350(6260):568-71
pubmed: 26405230
Mol Cell Biol. 1993 Oct;13(10):6501-8
pubmed: 8413249
Proc Natl Acad Sci U S A. 1992 May 15;89(10):4549-53
pubmed: 1316611
Cancer Res. 2013 Aug 1;73(15):4791-800
pubmed: 23749640
J Virol. 2020 Jan 6;94(2):
pubmed: 31666385
Oncogene. 2008 Nov 24;27(55):7018-30
pubmed: 19029942
PLoS One. 2013 Sep 23;8(9):e75056
pubmed: 24086435
Clin Microbiol Rev. 2003 Jan;16(1):1-17
pubmed: 12525422
Int J Cancer. 2014 May 1;134(9):2061-73
pubmed: 24136650
Virol J. 2008 Oct 14;5:118
pubmed: 18854037
Cancer Lett. 2002 May 28;179(2):205-12
pubmed: 11888675
Mol Cancer Res. 2018 Jan;16(1):90-102
pubmed: 28928286
Nat Rev Dis Primers. 2016 Dec 01;2:16086
pubmed: 27905473
J Clin Oncol. 2009 Oct 20;27(30):5088-93
pubmed: 19770372
Oral Oncol. 2015 Dec;51(12):1126-31
pubmed: 26421862
Int J Gynecol Pathol. 2019 Jan;38(1):1-10
pubmed: 29995652
Genes Dev. 1994 Mar 15;8(6):666-77
pubmed: 7926757
BMC Cancer. 2019 Mar 27;19(1):271
pubmed: 30917784
PLoS One. 2014 Jan 10;9(1):e78995
pubmed: 24427262
Virology. 2000 Nov 25;277(2):411-9
pubmed: 11080488