Celiac disease: clinical update.
Journal
Current opinion in gastroenterology
ISSN: 1531-7056
Titre abrégé: Curr Opin Gastroenterol
Pays: United States
ID NLM: 8506887
Informations de publication
Date de publication:
01 11 2021
01 11 2021
Historique:
pubmed:
31
8
2021
medline:
16
10
2021
entrez:
30
8
2021
Statut:
ppublish
Résumé
This review highlights literature from the past year and explores the impact on current understanding of celiac disease pathogenesis, diagnosis, and management. In contrast to earlier clinical trials, recent data suggests that early gluten introduction may protect against the development of celiac disease. Celiac disease is underdiagnosed, associated with high burden of disease and linked to excess mortality risk, yet, there remains considerable uncertainty regarding the utility of mass screening in asymptomatic individuals. The gut microbiome is increasingly implicated in celiac disease pathogenesis, although the exact mechanism is undefined. Probiotics have been proposed as a disease-modifying option for celiac disease but most studies assessing efficacy are of low-quality. Patients with celiac disease do not appear to be at increased risk of contracting or developing adverse outcomes from COVID-19. Little is known about the pathogenesis of nonceliac gluten sensitivity; however, recent findings suggest an autoimmune basis for the condition. Current understanding of celiac disease continues to advance, though significant knowledge gaps remain. Large, rigorous, prospectively designed studies are needed to further characterize celiac disease pathogenesis, management and therapeutic options.
Identifiants
pubmed: 34456226
doi: 10.1097/MOG.0000000000000785
pii: 00001574-202111000-00014
doi:
Substances chimiques
Glutens
8002-80-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
619-624Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
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