No Effect of Acute Eccentric Resistance Exercise on Immune Responses to Influenza Vaccination in Older Adults: A Randomized Control Trial.
aging
exercise
immunity
vaccine
virus
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
05
2021
accepted:
21
07
2021
entrez:
30
8
2021
pubmed:
31
8
2021
medline:
31
8
2021
Statut:
epublish
Résumé
Older adults are at elevated risk for morbidity and mortality caused by influenza. Vaccination is the primary means of prophylaxis, but protection is often compromised in older adults. As resistance exercise mobilizes immune cells into muscle, it may enhance vaccination response. Compare antibody and cell mediated immune responses to influenza vaccination in older adults who performed eccentric resistance exercise immediately prior to vaccination to those who did not exercise. Twenty nine resistance training-naive older adults (20 women, 73.9 ± 5.3 years) were randomized to 1 of 3 groups: vaccination in the same arm that exercised (Ex-S), vaccination in the opposite arm that exercised (Ex-Op), and seated rest (No-Ex). Exercise consisted of 10 sets of 5 eccentric unilateral repetitions at 80% of the pre-determined concentric one repetition maximum. Lateral raises were alternated with bicep curls. No-Ex sat quietly for 25 min. Following exercise or rest, all received the 2018 quadrivalent influenza vaccine (Seqirus Afluria) in the non-dominant deltoid. Antibody titers against each influenza vaccine strain were determined by hemagglutinin inhibition assays at baseline, 6-, and 24-weeks post-vaccination. Influenza-specific T cells were quantified after stimulation with the vaccine by intracellular cytokine staining. No significant group x time effects were found in antibody responses to any strain (interaction for A/H1N1: Acute arm eccentric exercise did not influence antibody titers or cell mediated immune responses to the influenza vaccine delivered post-exercise in older adults. More strenuous exercise may be required for exercise to act as an adjuvant. ClinicalTrials.gov Identifier: NCT03736759.
Identifiants
pubmed: 34456752
doi: 10.3389/fphys.2021.713183
pmc: PMC8388854
doi:
Banques de données
ClinicalTrials.gov
['NCT03736759']
Types de publication
Journal Article
Langues
eng
Pagination
713183Informations de copyright
Copyright © 2021 Elzayat, Markofski, Simpson, Laughlin and LaVoy.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10501-6
pubmed: 18650390
Trials. 2013 Jan 17;14:19
pubmed: 23324166
Nat Rev Immunol. 2009 Mar;9(3):185-94
pubmed: 19240757
J Sports Med Phys Fitness. 2003 Sep;43(3):404
pubmed: 14625524
Ageing Res Rev. 2012 Jul;11(3):404-20
pubmed: 22465452
Immunity. 2006 Jun;24(6):663-666
pubmed: 16782020
Vaccine. 2006 Feb 20;24(8):1159-69
pubmed: 16213065
J Strength Cond Res. 2002 May;16(2):202-8
pubmed: 11991771
Brain Behav Immun. 2010 May;24(4):623-30
pubmed: 20102734
Euro Surveill. 2013 Jan 31;18(5):
pubmed: 23399423
Clin Diagn Lab Immunol. 1995 Jan;2(1):120-1
pubmed: 7719904
Am J Physiol Cell Physiol. 2002 Jul;283(1):C289-95
pubmed: 12055098
Brain Behav Immun. 2014 Jul;39:33-41
pubmed: 24126151
Immunol Lett. 2016 Dec;180:54-65
pubmed: 27810335
Lancet. 2007 Aug 18;370(9587):580-9
pubmed: 17707753
Mol Cell Biochem. 1998 Feb;179(1-2):159-67
pubmed: 9543358
J Health Soc Behav. 1983 Dec;24(4):385-96
pubmed: 6668417
Exerc Immunol Rev. 2005;11:64-85
pubmed: 16385845
Ageing Res Rev. 2010 Jul;9(3):226-37
pubmed: 20385254
Arch Intern Med. 2006 May 22;166(10):1121-7
pubmed: 16717175
Health Econ. 1993 Oct;2(3):217-27
pubmed: 8275167
Eur J Appl Physiol. 2020 Jan;120(1):267-279
pubmed: 31811382
Eur J Haematol. 2020 Jul;105(1):75-84
pubmed: 32221992
Med Sci Sports Exerc. 2001 Sep;33(9):1490-5
pubmed: 11528337
Brain Behav Immun. 2007 Feb;21(2):209-17
pubmed: 16824730
Med Sci Sports Exerc. 1991 Sep;23(9):1028-34
pubmed: 1943622
J Am Geriatr Soc. 2009 Dec;57(12):2183-91
pubmed: 20121985
Aging (Milano). 1993 Dec;5(6):451-8
pubmed: 8161577
Nat Med. 2013 Oct;19(10):1305-12
pubmed: 24056771
Influenza Other Respir Viruses. 2009 Jan;3(1):37-49
pubmed: 19453440
Brain Behav Immun. 2010 Feb;24(2):236-42
pubmed: 19818846
Vaccine. 2010 May 21;28(23):3929-35
pubmed: 20394719
Vaccine. 2011 Feb 17;29(9):1812-23
pubmed: 21215831
Crit Rev Oncol Hematol. 2007 Nov;64(2):90-105
pubmed: 17446082
J Physiol. 2001 Dec 1;537(Pt 2):333-45
pubmed: 11731568
Vaccine. 2005 May 9;23(25):3232-5
pubmed: 15837226
J Physiol. 2003 Feb 15;547(Pt 1):125-32
pubmed: 12562965
J Sports Sci. 2003 Dec;21(12):991-1000
pubmed: 14748456
Virus Res. 2004 Jul;103(1-2):125-32
pubmed: 15163500
Exerc Immunol Rev. 2011;17:6-63
pubmed: 21446352
Clin Vaccine Immunol. 2017 Mar 6;24(3):
pubmed: 28100496
Vaccine. 2012 Oct 5;30(45):6389-95
pubmed: 22921739
J Gerontol A Biol Sci Med Sci. 2002 Sep;57(9):M557-62
pubmed: 12196490
J Appl Physiol (1985). 2002 May;92(5):1873-8
pubmed: 11960936
JAMA. 2004 Sep 15;292(11):1333-40
pubmed: 15367555
Brain Behav Immun. 2006 Mar;20(2):159-68
pubmed: 16102936
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56
pubmed: 11253156
J Appl Physiol (1985). 1994 Jun;76(6):2616-20
pubmed: 7928891
FASEB J. 2005 Feb;19(2):264-6
pubmed: 15556970
Lancet. 1981 Oct 24;2(8252):887-91
pubmed: 6117682
Hum Vaccin Immunother. 2014;10(6):1701-10
pubmed: 24732325
J Appl Physiol (1985). 2007 Mar;102(3):1090-8
pubmed: 17095638
Vaccine. 2004 Jun 2;22(17-18):2298-306
pubmed: 15149789
Am J Chin Med. 2007;35(4):597-607
pubmed: 17708626
JAMA. 2003 Jan 8;289(2):179-86
pubmed: 12517228
Gerontology. 2003 May-Jun;49(3):177-84
pubmed: 12679609
Med Sci Sports Exerc. 2011 Feb;43(2):249-58
pubmed: 20543750