Migraine in Multiple Sclerosis Patients Affects Functional Connectivity of the Brain Circuitry Involved in Pain Processing.
functional connectivity
functional magnetic resonance
migraine
multiple sclerosis
pain
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
04
2021
accepted:
21
06
2021
entrez:
30
8
2021
pubmed:
31
8
2021
medline:
31
8
2021
Statut:
epublish
Résumé
Migraine is particularly common in patients with multiple sclerosis (MS) and has been linked to the dysfunction of the brain circuitry modulating the peripheral nociceptive stimuli. Using MRI, we explored whether changes in the resting state-functional connectivity (RS-FC) may characterize the occurrence of migraine in patients with MS. The RS-FC characteristics in concerned brain regions were explored in 20 MS patients with migraine (MS+M) during the interictal phase, and compared with 19 MS patients without migraine (MS-M), which served as a control group. Functional differences were correlated to the frequency and severity of previous migraine attacks, and with the resulting impact on daily activities. In MS+M, the loss of periaqueductal gray matter (PAG) positive connectivity with the default mode network and the left posterior cranial pons was associated with an increase of migraine attacks frequency. In contrast, the loss of PAG negative connectivity with sensorimotor and visual network was linked to migraine symptom severity and related daily activities impact. Finally, a PAG negative connection was established with the prefrontal executive control network. Migraine in MS+M patients and its impact on daily activities, underlies RS-FC rearrangements between brain regions involved in pain perception and modulation.
Identifiants
pubmed: 34456850
doi: 10.3389/fneur.2021.690300
pmc: PMC8397382
doi:
Types de publication
Journal Article
Langues
eng
Pagination
690300Informations de copyright
Copyright © 2021 Pravatà, Riccitelli, Sestieri, Sacco, Cianfoni, Gobbi and Zecca.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Brain. 2004 Nov;127(Pt 11):2459-69
pubmed: 15471903
Hum Brain Mapp. 2015 Sep;36(9):3459-71
pubmed: 26138504
Elife. 2014 Mar 25;3:e01867
pubmed: 24668169
J Neurol Sci. 2006 May 15;244(1-2):137-41
pubmed: 16530789
Brain. 2014 Dec;137(Pt 12):3267-83
pubmed: 25367028
Behav Brain Res. 2010 Aug 25;211(2):215-9
pubmed: 20347878
J Cogn Neurosci. 2007 Jul;19(7):1081-8
pubmed: 17583985
Ann Neurol. 2011 Feb;69(2):292-302
pubmed: 21387374
Neuroimage. 2010 Mar;50(1):81-98
pubmed: 20006716
Headache. 2012 Oct;52 Suppl 2:111-6
pubmed: 23030543
Brain Connect. 2012;2(3):125-41
pubmed: 22642651
Hum Brain Mapp. 2016 Apr;37(4):1514-30
pubmed: 26821847
J Magn Reson Imaging. 2011 Jul;34(1):173-83
pubmed: 21618334
Br J Med Psychol. 1959;32(1):50-5
pubmed: 13638508
Pain. 2013 Dec;154(12):2691-2699
pubmed: 23911697
Neuroimage. 2007 Aug 1;37(1):90-101
pubmed: 17560126
Qual Life Res. 2003 Dec;12(8):963-74
pubmed: 14651415
Parkinsonism Relat Disord. 2021 Feb;83:71-78
pubmed: 33484978
Brain. 2003 May;126(Pt 5):1079-91
pubmed: 12690048
Cereb Cortex. 2018 Feb 1;28(2):726-737
pubmed: 29161362
Hum Brain Mapp. 2015 Dec;36(12):5051-63
pubmed: 26366641
Neuroimage Clin. 2014 Jul 05;5:322-31
pubmed: 25161898
J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
pubmed: 14399272
Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9673-8
pubmed: 15976020
Cephalalgia. 2007 Dec;27(12):1442-53
pubmed: 18034688
Neuron. 2007 Aug 2;55(3):377-91
pubmed: 17678852
Pain Med. 2015 Sep;16(9):1827-34
pubmed: 26177612
Neuroimage. 2021 Jan 15;225:117496
pubmed: 33181352
Neuroimage. 2012 Mar;60(1):505-22
pubmed: 22197740
Headache. 1998 Jul-Aug;38(7):507-15
pubmed: 15613166
Curr Opin Neurol. 2016 Dec;29(6):706-713
pubmed: 27749394
Neuroimage. 2008 Jan 1;39(1):527-37
pubmed: 17919929
Mult Scler Relat Disord. 2014 Jul;3(4):542-51
pubmed: 25877067
Neuroimage. 2012 Jan 16;59(2):1420-8
pubmed: 21889994
Front Neurol. 2015 Mar 16;6:55
pubmed: 25852634
J Neurosci. 2002 Sep 15;22(18):8183-92
pubmed: 12223572
Headache. 2005 Jun;45(6):670-7
pubmed: 15953299
Cereb Cortex. 2012 Jan;22(1):158-65
pubmed: 21616982
Brain. 2016 Jul;139(Pt 7):1987-93
pubmed: 27190019
Ann Neurol. 2011 Nov;70(5):838-45
pubmed: 22162064
Nat Rev Neurosci. 2007 Sep;8(9):700-11
pubmed: 17704812
Cephalalgia. 2013 Jul;33(9):629-808
pubmed: 23771276
J Neurophysiol. 2009 Jun;101(6):3270-83
pubmed: 19339462
J Neurol Neurosurg Psychiatry. 2019 Jul;90(7):796-804
pubmed: 30824632