Melatonin restores osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells and alleviates bone loss through the
HGF
PTEN
Wnt/β-catenin
bone marrow mesenchymal stem cells
melatonin
osteoporosis
Journal
Therapeutic advances in chronic disease
ISSN: 2040-6223
Titre abrégé: Ther Adv Chronic Dis
Pays: United States
ID NLM: 101532140
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
07
2020
accepted:
26
01
2021
entrez:
30
8
2021
pubmed:
31
8
2021
medline:
31
8
2021
Statut:
epublish
Résumé
Previous studies reported that melatonin exerts its effect on mesenchymal stem cell (MSC) survival and differentiation into osteogenic and adipogenic lineage. In the current study we aimed to explore the effect of melatonin on osteoporosis and relevant mechanisms. Real-time qualitative polymerase chain reaction (RT-qPCR) and Western blot analysis were conducted to determine expression of Melatonin prevented bone loss in OVX mice. Melatonin increased ALP expression and reduced TRAP5b expression. Melatonin could potentially enhance osteogenic differentiation of BMSCs and retard bone loss through the
Sections du résumé
BACKGROUND
BACKGROUND
Previous studies reported that melatonin exerts its effect on mesenchymal stem cell (MSC) survival and differentiation into osteogenic and adipogenic lineage. In the current study we aimed to explore the effect of melatonin on osteoporosis and relevant mechanisms.
METHODS
METHODS
Real-time qualitative polymerase chain reaction (RT-qPCR) and Western blot analysis were conducted to determine expression of
RESULTS
RESULTS
Melatonin prevented bone loss in OVX mice. Melatonin increased ALP expression and reduced TRAP5b expression.
CONCLUSION
CONCLUSIONS
Melatonin could potentially enhance osteogenic differentiation of BMSCs and retard bone loss through the
Identifiants
pubmed: 34457228
doi: 10.1177/2040622321995685
pii: 10.1177_2040622321995685
pmc: PMC8392808
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2040622321995685Informations de copyright
© The Author(s), 2021.
Déclaration de conflit d'intérêts
Conflict of interest statement: The authors declare that there is no conflict of interest.
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