The Fibrosis-Targeted Collagen/Integrins Gene Profile Predicts Risk of Metastasis in Pulmonary Neuroendocrine Neoplasms.
collagens
extracellular matrix
integrins
metastasis
pulmonary neuroendocrine neoplasms
surgical resection
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
05
2021
accepted:
16
06
2021
entrez:
30
8
2021
pubmed:
31
8
2021
medline:
31
8
2021
Statut:
epublish
Résumé
Recently, collagen/integrin genes have shown promise as predictors of metastasis mainly in non-small cell lung cancer and breast cancer. However, it is unknown if these gene expression profiling differ in metastatic potential of pulmonary neuroendocrine neoplasms (PNENs). In this study, we sought to identify differentially expressed collagen/integrin genes in PNENs in order to understand the molecular mechanisms underlying the development of stroma-associated fibrosis for invasion and metastasis. We compared collagen/integrin gene expression profiling between PNE tumors (PNETs) and PNE carcinomas (PNECs) using a two-stage design. First, we used PCR Array System for 84 ECM-related genes, and among them, we found
Identifiants
pubmed: 34458147
doi: 10.3389/fonc.2021.706141
pmc: PMC8385766
doi:
Types de publication
Journal Article
Langues
eng
Pagination
706141Informations de copyright
Copyright © 2021 Prieto, Machado-Rugolo, Baldavira, Velosa, Teodoro, Saber and Capelozzi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Thorac Oncol. 2020 Feb;15(2):231-247
pubmed: 31751681
Nat Rev Cancer. 2006 May;6(5):392-401
pubmed: 16572188
Cancer Cell. 2012 Mar 20;21(3):309-22
pubmed: 22439926
Transl Res. 2019 Jul;209:55-67
pubmed: 30871956
Front Genet. 2020 Aug 28;11:1023
pubmed: 33005184
Nucleic Acids Res. 2011 Jan;39(Database issue):D1005-10
pubmed: 21097893
Annu Rev Cell Dev Biol. 2005;21:247-69
pubmed: 16212495
Nat Med. 2011 Mar;17(3):320-9
pubmed: 21383745
J Clin Oncol. 2017 Sep 10;35(26):3065-3074
pubmed: 28498782
Cancer. 1993 Feb 15;71(4):1368-83
pubmed: 8435813
Clin Cancer Res. 2003 Aug 1;9(8):3098-104
pubmed: 12912961
J Thorac Oncol. 2016 Jan;11(1):39-51
pubmed: 26762738
Front Oncol. 2021 Apr 15;11:650293
pubmed: 33937057
Science. 2016 Apr 15;352(6283):353-8
pubmed: 27013428
Int J Mol Sci. 2020 Jul 13;21(14):
pubmed: 32668815
Mod Pathol. 2017 Oct;30(10):1422-1432
pubmed: 28643792
Transl Lung Cancer Res. 2020 Jun;9(3):860-878
pubmed: 32676352
Front Endocrinol (Lausanne). 2021 Apr 27;12:669484
pubmed: 33986731
Hum Pathol. 2010 Feb;41(2):239-48
pubmed: 19828174
Exp Cell Res. 1994 Feb;210(2):215-23
pubmed: 8299719
PLoS One. 2016 Aug 11;11(8):e0161007
pubmed: 27513329
J Cell Physiol. 2005 Feb;202(2):411-21
pubmed: 15389593
Nat Genet. 2003 Jan;33(1):49-54
pubmed: 12469122
Lab Invest. 1983 Dec;49(6):636-49
pubmed: 6317982
Mod Pathol. 2018 Dec;31(12):1770-1786
pubmed: 30140036
PeerJ. 2018 Jul 2;6:e5180
pubmed: 30002985
Nat Rev Mol Cell Biol. 2014 Dec;15(12):771-85
pubmed: 25370693
Mol Cancer Res. 2016 Mar;14(3):287-95
pubmed: 26631572
Gene. 2018 Jul 30;665:57-66
pubmed: 29702185
Biochem Genet. 2021 Apr 29;:
pubmed: 33928467
Mod Pathol. 2000 May;13(5):511-20
pubmed: 10824922
Nat Rev Cancer. 2018 Sep;18(9):533-548
pubmed: 30002479
Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5
pubmed: 23193258
J Exp Clin Cancer Res. 2019 Mar 6;38(1):115
pubmed: 30841909
Nat Genet. 2012 Oct;44(10):1104-10
pubmed: 22941188
Eur Respir J. 2017 Jun 1;49(6):
pubmed: 28572122
Clin Cancer Res. 2016 Jul 15;22(14):3618-29
pubmed: 26960398
Exp Cell Res. 2010 May 1;316(8):1324-31
pubmed: 20211171
Onco Targets Ther. 2016 Apr 18;9:2317-27
pubmed: 27143927
J Cell Biol. 2013 Jun 24;201(7):1069-84
pubmed: 23798731
Front Oncol. 2020 Aug 18;10:1488
pubmed: 33014790
Front Oncol. 2021 Apr 22;11:650453
pubmed: 33968752
Clin Cancer Res. 2018 Jan 1;24(1):33-42
pubmed: 29066508
Nat Genet. 2015 Oct;47(10):1200-5
pubmed: 26343384
Front Cell Dev Biol. 2015 May 29;3:33
pubmed: 26075202
Front Oncol. 2015 Oct 20;5:224
pubmed: 26539408
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Cancer Med. 2020 Jul;9(13):4836-4849
pubmed: 32391978
Nucleic Acids Res. 2017 Jan 4;45(D1):D362-D368
pubmed: 27924014
Front Genet. 2021 Jan 21;11:634634
pubmed: 33552145
Mod Pathol. 2017 Jun;30(6):797-809
pubmed: 28256572
Cancer Treat Res Commun. 2020 Apr 20;23:100174
pubmed: 32413603
Anticancer Res. 2018 Aug;38(8):4593-4605
pubmed: 30061226
Pathol Res Pract. 2020 Dec;216(12):153277
pubmed: 33223279
Ann Oncol. 2017 Mar 1;28(3):604-610
pubmed: 27993815
Oncol Res. 2019 Feb 5;27(2):203-210
pubmed: 29523217
Nat Rev Cancer. 2014 Jun;14(6):430-9
pubmed: 24827502
Transl Lung Cancer Res. 2021 Jan;10(1):71-79
pubmed: 33569294