Single-chain Fragment variable antibody targeting cholecystokinin-B receptor for pain reduction.
ANOVA, analysis of variance
ARM, antibody ribosome mRNA
Anxiety
BBB, blood–brain barrier
CCK-8, cholecystokinin octapeptide
CCK-BR, cholecystokinin B receptor
CPP, conditioned place preference
Chronic pain
DRG, dorsal root ganglia
Depression
Eukaryotic ribosome display
FRICT-ION, foramen rotundum inflammatory compression trigeminal infraorbital nerve model
GPCR, G-protein-coupled receptor
IACUC, Institutional Animal Care and Use Committee
ION, infraorbital nerve
MΩ, megaOhms
PBS, phosphate buffered saline
SEM, standard error of the mean
TG, trigeminal ganglia
ms, milliseconds
pA, picoAmps
scFv
scFv, single-chain Fragment variable antibody
Journal
Neurobiology of pain (Cambridge, Mass.)
ISSN: 2452-073X
Titre abrégé: Neurobiol Pain
Pays: United States
ID NLM: 101705141
Informations de publication
Date de publication:
Historique:
received:
18
06
2021
revised:
09
07
2021
accepted:
09
07
2021
entrez:
30
8
2021
pubmed:
31
8
2021
medline:
31
8
2021
Statut:
epublish
Résumé
The cholecystokinin B receptor and its neuropeptide ligand are upregulated in chronic neuropathic pain models. Single-chain Fragment variable antibodies were generated as preferred non-opioid targeting therapy blocking the cholecystokinin B receptor to inhibit chronic neuropathic pain models
Identifiants
pubmed: 34458647
doi: 10.1016/j.ynpai.2021.100067
pii: S2452-073X(21)00008-8
pmc: PMC8378781
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100067Subventions
Organisme : BLRD VA
ID : I01 BX002695
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS039041
Pays : United States
Organisme : NIDCR NIH HHS
ID : R21 DE028096
Pays : United States
Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
PLoS One. 2014 Dec 01;9(12):e113442
pubmed: 25438047
Nat Med. 2010 Nov;16(11):1248-57
pubmed: 20948530
Life Sci. 1998;62(10):947-52
pubmed: 9496717
Nat Commun. 2018 Apr 13;9(1):1461
pubmed: 29654232
Arch Gen Psychiatry. 1991 Jul;48(7):603-10
pubmed: 2069490
Regul Pept. 2000 Sep 25;93(1-3):79-83
pubmed: 11033055
Hum Brain Mapp. 2018 Feb;39(2):609-621
pubmed: 29105886
Brain. 2019 May 1;142(5):1215-1226
pubmed: 30887021
Pharmacol Rev. 2018 Apr;70(2):315-347
pubmed: 29500312
Arch Gen Psychiatry. 1989 Jun;46(6):511-7
pubmed: 2730276
Appl Biochem Biotechnol. 2013 Jan;169(1):159-69
pubmed: 23160949
Brain Res. 1996 Nov 4;738(2):313-8
pubmed: 8955527
MAbs. 2017 Jul;9(5):735-741
pubmed: 28475474
Expert Opin Biol Ther. 2006 Feb;6(2):177-87
pubmed: 16436043
J Pain Res. 2020 Jan 15;13:123-130
pubmed: 32021401
Nat Neurosci. 2012 Jul 01;15(8):1117-9
pubmed: 22751038
J Pain. 2003 Oct;4(8):465-70
pubmed: 14622667
J Comp Neurol. 2019 Aug 1;527(11):1857-1871
pubmed: 30734936
Pain. 2000 Sep;87(3):265-273
pubmed: 10963906
Clin Cancer Res. 2000 Aug;6(8):3081-7
pubmed: 10955787
Curr Opin Pharmacol. 2016 Dec;31:68-75
pubmed: 27710813
Clin Dev Immunol. 2012;2012:980250
pubmed: 22474489
J Neurophysiol. 2014 Mar;111(5):1065-76
pubmed: 24335219
Mol Pain. 2018 Jan-Dec;14:1744806918796763
pubmed: 30178698
J Gastroenterol Hepatol. 1992 May-Jun;7(3):293-7
pubmed: 1611017
J Neurosci. 2005 Jan 12;25(2):409-16
pubmed: 15647484
Exp Neurobiol. 2017 Aug;26(4):179-185
pubmed: 28912640
Pain. 2003 Jul;104(1-2):93-101
pubmed: 12855318
J Psychiatry Neurosci. 2005 May;30(3):167-75
pubmed: 15944741
J Pain Res. 2019 Jul 03;12:2009-2026
pubmed: 31308730
Brain. 2016 Jul;139(Pt 7):1958-70
pubmed: 27190016
Science. 1984 Apr 27;224(4647):395-6
pubmed: 6546809
Pharmacol Biochem Behav. 2006 Dec;85(4):787-95
pubmed: 17196636
J Clin Psychopharmacol. 1995 Dec;15(6):428-34
pubmed: 8748432
Eur J Pain. 2018 May;22(5):875-888
pubmed: 29350446
Pain. 2020 Sep 1;161(9):2089-2106
pubmed: 32639365
Scand J Clin Lab Invest Suppl. 2001;234:19-27
pubmed: 11713976
Methods Mol Biol. 2018;1827:235-268
pubmed: 30196501
Behav Brain Res. 2008 Mar 17;188(1):62-70
pubmed: 18054398
BioDrugs. 2013 Feb;27(1):55-67
pubmed: 23344946
Mol Pain. 2016 Aug 28;12:
pubmed: 27573516
Prog Neurobiol. 2012 May;97(2):190-204
pubmed: 22120646
Brain Res Brain Res Rev. 2004 Nov;46(3):295-309
pubmed: 15571771
Neurosci Lett. 1993 Apr 2;152(1-2):129-32
pubmed: 8515864
Pain. 2000 Aug;87(2):149-158
pubmed: 10924808
Cell. 2009 Oct 16;139(2):267-84
pubmed: 19837031
Front Behav Neurosci. 2017 Apr 28;11:77
pubmed: 28503137
J Biol Chem. 2013 Jul 5;288(27):19760-72
pubmed: 23689510
Neurosci Biobehav Rev. 1998 Oct;22(6):815-25
pubmed: 9809313
J Neurosci. 2004 Nov 17;24(46):10410-5
pubmed: 15548656
J Psychiatry Neurosci. 2003 May;28(3):171-81
pubmed: 12790157
J Biomol Screen. 2016 Jan;21(1):24-34
pubmed: 26450103
Drugs Today (Barc). 2020 Jan;56(1):5-19
pubmed: 32055802
Pharmacol Toxicol. 2002 Dec;91(6):398-403
pubmed: 12688385
Biol Psychiatry. 1995 Apr 1;37(7):462-6
pubmed: 7786960
Cell Commun Signal. 2019 Jun 18;17(1):68
pubmed: 31215470
Behav Brain Sci. 1997 Sep;20(3):420-5; discussion 435-513
pubmed: 10097004
Am J Trop Med Hyg. 2019 Jul;101(1):198-206
pubmed: 31074409
Cephalalgia. 2017 Jun;37(7):670-679
pubmed: 28403646
Protein Eng Des Sel. 2009 Mar;22(3):199-208
pubmed: 18927231
N Engl J Med. 2019 Dec 5;381(23):2230-2241
pubmed: 31800988
Brain. 2013 Sep;136(Pt 9):2751-68
pubmed: 23983029
J Neurosci. 2014 Dec 10;34(50):16835-50
pubmed: 25505335
Wellcome Open Res. 2018 Jun 25;3:78
pubmed: 30079380
Eur J Neurosci. 2004 Sep;20(6):1577-86
pubmed: 15355324
J Oral Facial Pain Headache. 2014 Winter;28(1):52-60
pubmed: 24482788
J Neurophysiol. 2001 Jan;85(1):280-6
pubmed: 11152727
J Neurosci. 2014 Mar 12;34(11):3878-87
pubmed: 24623766
Brain. 2009 Mar;132(Pt 3):778-87
pubmed: 19050032
J Pain. 2011 Jun;12(6):667-76
pubmed: 21354865
Regul Pept. 2001 Sep 15;101(1-3):25-33
pubmed: 11495676
Bio Protoc. 2020 Apr 20;10(8):e3591
pubmed: 33659557
Expert Opin Biol Ther. 2019 Dec;19(12):1307-1317
pubmed: 31550937
J Neurosci. 1992 Dec;12(12):4854-66
pubmed: 1334505
Neuropeptides. 1996 Apr;30(2):203-6
pubmed: 8771563
J Neurosci. 2005 Aug 31;25(35):7896-904
pubmed: 16135746
J Neurochem. 1999 Feb;72(2):858-67
pubmed: 9930763
Nat Med. 2021 Jan;27(1):174-182
pubmed: 33398159
PLoS One. 2018 Nov 16;13(11):e0205743
pubmed: 30444865
J Med Chem. 2006 May 18;49(10):2868-75
pubmed: 16686530